As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert.
Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively.
Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.
PART 1 Basic Research Topics
Soft Matter Physics of Lipid Membrane-Based Assemblies
Daniel Harries and Uri Raviv
Nonlamellar Lipid Aggregates
Charlotte E. Conn and John M. Seddon
Extractant Molecules as Hosts in Surfactant Monolayers or Bilayers
Olivier Diat, Pierre Bauduin, Thomas Zemb, Jean-Francois Dufrêche, and Daniel Meyer
Molecular Dynamics of Lipid Bilayers: Standards, Successes, and Works in Progress
Edward Lyman and Sandeep Patel
New Insights into the Peptide-Membrane Partitioning Equilibrium from In Silico Free Surface-to-Bilayer Peptide Insertion
Jakob P. Ulmschneider
Basic Aspects and Applications of Lipids and Protein Dynamics
Maikel C. Rheinstädter
Lipid Diversity and Its Implications on Membrane Organization
Jianjun Pan, Norbert Kučerka, Mu-Ping Nieh, Frederick A. Heberle, Paul Drazba, and John Katsaras
Liposome-Based Models for Membrane Rafts: Methodology and Applications
Frederick A. Heberle, Robin S. Petruzielo, Shih Lin Goh, Tatyana M. Konyakhina, David G. Ackerman, Jonathan J. Amazon, and Gerald W. Feigenson
Nanoscale Membrane Mimetics for Biophysical Studies of Membrane Proteins
Catherine J. Baker, Ilia G. Denisov, and Stephen G. Sligar
Microemulsions: Biomimetic Systems for Characterization of Biomembranes and Their Associated Biomolecules
Douglas G. Hayes
Locations of Small Biomolecules in Model Membranes
Drew Marquardt and Thad A. Harroun
Georg Pabst and Karl Lohner
The Structural Diversity of DNA–Phospholipid Aggregates
Daniela Uhríková and Petra Pullmannová
An Update on Active Membranes
David Lacoste and Patricia Bassereau
PART 2 Technology
Medical Applications of Lipid Nanoparticles
David B. Fenske and Pieter R. Cullis
Polymer-Modified Liposomes: From Long-Circulating to Multifunctional
Aleksandr Piroyan, Alexander Koshkaryev, Robert D. Riehle, and Vladimir P. Torchilin
Drug Formulations Based on Self-Assembled Liquid Crystalline Nanostructures
Anan Yaghmur, Jesper Østergaard, Susan Weng Larsen, Henrik Jensen, Claus Larsen, and Michael Rappolt
Tethered Lipid Membranes
Wolfgang Knoll, Renate L. C. Naumann, and Christoph Nowak
Ion-Transporting Supported and Tethered Lipid Bilayers That Incorporate Biological Membrane Transport Proteins
Donald K. Martin, Bruce A. Cornell, Lavinia Liguori, Jean-Luc Lenormand, Jean-Pierre Alcaraz, Gwenaël Scolan, and Philippe Cinquin
Role of Liposomes in Textile Dyeing
Meritxell Martí, Alfonso de la Maza, José L. Parra, and Luisa Coderch
Micro- and Nanoparticles for Controlling Microorganisms in Foods
Jochen Weiss, Qixin Zhong, Federico Harte, and P. Michael Davidson
Georg Pabst received his Ph.D. in physics from the Graz University of Technology, Austria, and completed postdoctoral research at the Canadian Research Council, Chalk River, Ontario. After his return to Austria, he was a senior research officer at the Austrian Academy of Sciences and moved to the University of Graz, where he currently holds the position of assistant professor. His research is focused on the physics of biological membranes with the aim of delineating the functional role of membrane lipids in cellular transport and signaling.
Norbert Kucerka received his Ph.D. in biophysics from the Faculty of Mathematics, Physics and Informatics at Comenius University in Bratislava, Slovakia, in 2003. He completed his postdoctoral research at the Department of Physics, Carnegie Mellon University in Pittsburgh, Pennsylvania, and as a National Sciences and Engineering Research Council visiting fellow at the Canadian Neutron Beam Centre, Chalk River, Ontario. In 2008, he joined the National Research Council of Canada, recently becoming an associate research officer. His work is focused on determining the structure of biological model membranes and unraveling the structure–function relationships in their highly complex behavior.
Mu-Ping Nieh received his Ph.D. in the Department of Chemical Engineering at the University of Massachusetts, Amherst, USA. He then worked as a postdoctoral researcher—a joint position at National Institute of Standards and Technology and The Pennsylvania State University. In 2002, he joined the National Research Council, Canada, at Chalk River, Ontario. Eight years later (2010), he became an associate professor in the Department of Chemical and Biomolecular Engineering at the University of Connecticut, Storrs, USA. His research primarily focuses on the underlying principles of spontaneous structures formed by soft materials, including lipids, polymers, and proteins, seeking a fundamental understanding of the structure–function relationship of self-assemblies.
John Katsaras is a senior scientist and distinguished R&D staff at Oak Ridge National Laboratory (ORNL). He received his Ph.D. in biophysics from the University of Guelph, Ontario, Canada. Prior to joining ORNL, he was a principal research officer at the National Research Council of Canada. He is internationally recognized for scientific contributions to the field of membrane biophysics, to materials of biological and medical relevance, and the application of x-ray and neutron scattering techniques to biologically relevant systems.