1st Edition

Practical Phlebology Deep Vein Thrombosis

By Anthony J. Comerota Copyright 2014

    The latest volume in the Practical Phlebology series, Deep Vein Thrombosis provides trainee and practicing physicians with the ideal illustrative guide to the etiology, diagnosis, and management of deep vein thrombosis (DVT). Based on peer-reviewed literature and quality clinical trials, the book is also an essential resource for academicians.

    Topics include:

    • Epidemiology, natural history, and etiology of DVT
    • DVT prophylaxis
    • Diagnostic techniques
    • Anticoagulation, thrombus removal, catheter-based interventions, and thrombolysis
    • Inferior vena cava filters
    • Heparin-induced thrombocytopenia
    • Femoral endovenectomy and endoluminal recanalization

    Natural history of acute DVT

    DVT and mortality

    Thrombus resolution

    DVT, valve function, and recurrence

    Not all DVTs are the same

    Etiology

    Etiology

    Vein wall injury

    DVT prophylaxis

    Risk stratification

    Prophylaxis guidelines

    References

    Diagnosis of acute DVT

    Clinical evaluation

    Ascending phlebography

    Venous duplex ultrasound

    Computerized tomographic venography

    Magnetic resonance venography

    D-dimer tests

    Anticoagulants

    Unfractionated heparin

    Low-molecular-weight heparins

    Fondaparinux

    Direct thrombin inhibitors

    Warfarin compounds (Vitamin K antagonists)

    Danaparoid

    References

    New oral anticoagulants

    Clinical trial development

    VTE prophylaxis in orthopedic patients

    VTE prophylaxis in medically ill patients

    Treatment of acute VTE

    Reversal of the anticoagulant effect of NOACs

    Management of acute DVT: Anticoagulation

    Initial anticoagulation

    Duration of anticoagulation

    Recurrent DVT

    DVT and malignancy

    Tailoring duration of anticoagulation

    Ambulation and compression

    Strategy of thrombus removal

    Background

    Rationale for thrombus removal

    Treatment options for thrombus removal

    Recurrent DVT

    Inferior vena cava filters

    Indications

    Filter types

    Clinical decision making

    Randomized trials

    Hemodynamic performance

    Decision matrix

    Heparin-induced thrombocytopenia

    Overview

    Clinical presentation

    Diagnosis

    Management

    Common femoral endovenectomy and endoluminal recanalization for chronic postthrombotic iliofemoral venous obstruction

    Overview

    Operative procedure

    Operative complications

    Clinical outcomes

    Perspective

    Biography

    Anthony J. Comerot, MD, FACS, FACC, is the director of the Jobst Vascular Institute at Toledo Hospital in Ohio and adjunct professor of surgery at the University of Michigan. He received his medical degree from Temple University School of Medicine in Philadelphia, Pennsylvania, and completed his general surgery residency at Temple University Hospital and his vascular surgery fellowship at Good Samaritan Hospital, Cincinnati, Ohio.

    Dr. Comerota has been a major contributor to the development of some of the newest forms of treatment for vascular disease and has been the principal investigator of seven major national trials and a co-investigator of numerous others. His research interests span a broad range of arterial and venous disorders, including the management of acute DVT, therapeutic angiogenesis, noninvasive diagnosis of vascular disease, development of new devices, new drug development, and the effects of platelet-inhibiting drugs. He has received over $5 million in research funding, including support from the National Institutes of Health (NIH), the American Heart Association, and the American Diabetes Association.

     

    "This is an invaluable book for clinicians wishing to increase their knowledge about DVT and how to care for patients with this disease process. … well written with complete yet understandable explanations of the disease process and how to treat patients with each type of DVT." (4 stars)
    —Courtney M Daly, MD (Northwestern University Feinberg School of Medicine) in Doody’s Review Service