Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering

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ISBN 9781439883075
Cat# K13908



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ISBN 9781439883082
Cat# KE14120



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  • Focuses on the use of silica-based mesoporous materials in drug delivery systems, stimuli-responsive materials, and bone tissue regeneration
  • Explores promising alternatives for the clinical field in the near future
  • Presents the basic principles and recent advances in the field
  • Written so that students and researchers beginning in this area can learn the basic principles and recent advances in the field


Developments in mesoporous ceramics in drug delivery, nanomedicine, and bone tissue regeneration have opened promising developments in biomedical research, many applicable in the clinic in the near future. Due to the ability to fine-tune the physicochemical properties of these materials, the field has experienced an impressive burst in the number of publications. As controlled drug delivery systems are one of the most promising applications for human health care, it is now necessary to set the milestones of this technology, from the very basic to the most advanced.

Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering is a comprehensive overview of silica-based mesoporous materials with special attention given to their use in drug delivery systems, sophisticated stimuli-responsive materials, and bone tissue engineering. The book provides a comprehensive overview of the basic aspects of the properties of mesoporous materials, with a focus on textural properties such as surface and porosity. Starting from this consolidated knowledge, it then addresses various aspects of more sophisticated stimuli-responsive materials and bone tissue engineering, detailing the research and development of these biomedical applications.

Table of Contents

Biocompatible and Bioactive Mesoporous Ceramics
General Properties of Ordered Mesoporous Ceramics
Biodegradable and Bioactive Ceramics
Calcium Phosphates
Organic Functionalization of Ordered Mesoporous Ceramics
In Vitro Studies
In Vivo Studies

Mesoporous Ceramics as Drug Delivery Systems
Adsorption of Biomolecules
Release of Biomolecules
Oral Drug Delivery
Topical and Transdermal Drug Delivery
Local Drug Delivery
Targeted Drug Delivery

Stimuli-Responsive Drug Delivery Systems Based on Mesoporous Silica
pH as Release Trigger
Temperature as Release Trigger
Redox Potential as Release Trigger
Light as Release Trigger
Magnetic Field as Release Trigger
Ultrasounds as Release Trigger
Enzymes as Release Triggers
Antigens as Release Triggers
Aptamer Target as Release Trigger
Dual Stimuli as Release Trigger

Mesoporous Silica Nanoparticles in Nanomedicine
Drug Delivery
Gene Therapy
Hyperthermia-Based Therapy
Theranostic Nanomedicine
Biocompatibility and Toxicity

Bone Tissue Regeneration
Tissue Engineering
Bone Tissue Engineering
Biocompatibility of Ordered Mesoporous Silica

Author Bio(s)

Maria Vallet-Regi is Head of the Department of Inorganic and Bioinorganic Chemistry and Faculty of Pharmacy at Universidad Complutense de Madrid, Spain.

Miguel Manzano is also with Universidad Complutense de Madrid, Spain.