Developments in mesoporous ceramics in drug delivery, nanomedicine, and bone tissue regeneration have opened promising developments in biomedical research, many applicable in the clinic in the near future. Due to the ability to fine-tune the physicochemical properties of these materials, the field has experienced an impressive burst in the number of publications. As controlled drug delivery systems are one of the most promising applications for human health care, it is now necessary to set the milestones of this technology, from the very basic to the most advanced.
Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering is a comprehensive overview of silica-based mesoporous materials with special attention given to their use in drug delivery systems, sophisticated stimuli-responsive materials, and bone tissue engineering. The book provides a comprehensive overview of the basic aspects of the properties of mesoporous materials, with a focus on textural properties such as surface and porosity. Starting from this consolidated knowledge, it then addresses various aspects of more sophisticated stimuli-responsive materials and bone tissue engineering, detailing the research and development of these biomedical applications.
Biocompatible and Bioactive Mesoporous Ceramics
General Properties of Ordered Mesoporous Ceramics
Biodegradable and Bioactive Ceramics
Organic Functionalization of Ordered Mesoporous Ceramics
In Vitro Studies
In Vivo Studies
Mesoporous Ceramics as Drug Delivery Systems
Adsorption of Biomolecules
Release of Biomolecules
Oral Drug Delivery
Topical and Transdermal Drug Delivery
Local Drug Delivery
Targeted Drug Delivery
Stimuli-Responsive Drug Delivery Systems Based on Mesoporous Silica
pH as Release Trigger
Temperature as Release Trigger
Redox Potential as Release Trigger
Light as Release Trigger
Magnetic Field as Release Trigger
Ultrasounds as Release Trigger
Enzymes as Release Triggers
Antigens as Release Triggers
Aptamer Target as Release Trigger
Dual Stimuli as Release Trigger
Mesoporous Silica Nanoparticles in Nanomedicine
Biocompatibility and Toxicity
Bone Tissue Regeneration
Bone Tissue Engineering
Biocompatibility of Ordered Mesoporous Silica
Maria Vallet-Regi is Head of the Department of Inorganic and Bioinorganic Chemistry and Faculty of Pharmacy at Universidad Complutense de Madrid, Spain.
Miguel Manzano is also with Universidad Complutense de Madrid, Spain.