Cardiovascular Diseases: Nutritional and Therapeutic Interventions

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Features

  • Covers cardiovascular diseases including angina, atherosclerosis, heart attack, high blood pressure, and stroke
  • Combines perspectives of scientists and clinicians for prevention and cure of various cardiovascular diseases
  • Focuses on nutritional therapeutics including pomegranate, red wine, tea, olive oil, garlic, ginseng, curcumin, and fruits and vegetables
  • Discusses how nutrigenomics can alleviate imprinted cardiac diseases through tailored diets
  • Describes medical options including drug, gene, and stem cell therapies
  • Examines cardiovascular disease cause and prevention as it relates to lifestyle changes, stress, yoga, and meditation

Summary

With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases.

Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect.

Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.

Table of Contents

Part I: Epidemiological Study of Heart Disease

Epidemiology of Cardiovascular Disease
Salim S. Abunnaja and Juan A. Sanchez

Part II: Epigenetic Modifications in Arterial and Heart Diseases

Epigenetics of Atherosclerosis: Current Insights and Future Perspectives
Lucia Migliore and Maria Grazia Andreassi

Genetic and Epigenetic Basis of Myocardial Ischemia and Reperfusion Injury: Protection by Dietary Antioxidants and Chromatin-Modifying Compounds
Tom C. Karagiannis, Katherine Ververis, and Paul V. Licciardi

Attenuation of Myocardial Ischaemia-Reperfusion Injury by Probiotic Bacteria
Paul V. Licciardi, Katherine Ververis, Zheng Q. Toh, and Tom C. Karagiannis

Part III: Cardiovascular Disease

Lipid Regulation of Cardiac Ion Channels in Heart Disease
Lixia Yue, Zhichao Yue, and Jia Xie

Arginine, Tetrahydrobiopterin, and Nitric Oxide in Myocardial Protection
Murugesan Velayutham, Lawrence J. Druhan, and Arturo J. Cardounel

Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury
Tuanzhu Ha, Li Liu, Jim Kelley, David Williams, and Chuanfu Li

Aging, Nutrients, and Endogenous Stem Cell Populations
Ewa K. Zuba-Surma, Harold Elias, and Buddhadeb Dawn

Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis
Hongyan Zhu and Guo-Chang Fan

Doxorubicin-Induced Cardiomyopathy and Benefits from Vitamin C
Ana Ludke, Gauri Akolkar, Gunjan Bajpai, Neelam Khaper, and Pawan K. Singal

Hypoxic Preconditioning of Stem Cells to Treat Myocardial Infarction
Simi M. Chacko and Periannan Kuppusamy

Diabetes-Associated Cardiomyopathy and Cell Therapy
Edith Hochhauser, Michael Morozov, and Michael Arad

Part IV: Nutritional and Other Therapeutic Interventions for CVD

Pluripotent Stem Cell Therapy for Cardiac Regeneration
Kiwon Ban, Jaemin Byun, Sangsung Kim, Sukwon Koh, and Young-Sup Yoon

Nanotechnology and Cardiovascular Diseases
Kannan Badri Narayanan and Natarajan Sakthivel

Heart-Healthy Diet: "The Art and Science of Perfecting the Plate"
S. Sivasankaran

Nutritional Therapy in the Treatment of Oxidative-Stress-Induced Heart Disease
Yen-Chun Ho, Meng-Ling Wu, and Shaw-Fang Yet

Therapeutic Strategies for Metabolic Syndrome and Lifestyle-Related Disease
Hajime Otani

Alcohol and Heart Health: Is the Preconditioning Effect of Wine Drinking Related to Alcohol-Induced Changes in Cellular Fatty Acid Profile?
Joël de Leiris, Stéphane Tanguy, and François Boucher

Antioxidative Compounds: Description and Evidence of Clinical Relevance
Thomas F. Whayne, Jr.

Garlic in Cardiovascular Health: Winnowing the Fact from Artifacts
Sanjay K. Banerjee and Subir K. Maulik

Resveratrol Emerges As a Miracle Cardioprotective Phytochemical Polyphenol and Nutraceutical
Vaithinathan Selvaraju, Mandip Joshi, Sainath R. Kotha, Narasimham L. Parinandi, and Nilanjana Maulik

Potent Beneficial Effects of Vegetables and Fruits of Cardiovascular Diseases
Namasivayam Nalini and Jesudoss Victor Antony Santiago

Phosphodiesterase-5 Inhibitors in Cardioprotection
Mahesh Thirunavukkarasu and Murugavel Ponnusamy

Flaxseed and Its Components in Coronary Artery and Peripheral Vascular Disease
Kailash Prasad

Flaxseed and Blood Pressure
Kailash Prasad

Curcumin and Cardiovascular Diseases
Sayantan Jana and Snehasikta Swarnakar

Effect of Fruit and Vegetable Intake on CVD Risk Factors in Humans
Lars O. Dragsted

Melon for Cardiovascular Health
Shubin K. Saha and Sibu P. Saha

Botanicals as Angiotensin Converting Enzyme Inhibitors Useful in Hypertension
Pulok K. Mukherjee, Sushil Kumar Chaudhary, Neelesh K. Nema, and B.P. Saha

Yoga, Meditation, and Healthy Heart: Principles and Evidence
Sasidharan Bijulal

Index

Editor Bio(s)

Nilanjana Maulik, Ph.D., FAHA, is a professor in the Department of Surgery, University of Connecticut Medical Center, Farmington, Connecticut. She is also a faculty member of the Cell Biology Graduate Program since 2004 at the University of Connecticut Health Center. Professor Maulik’s research focuses on the molecular mechanism of myocardial angiogenesis, ischemia/reperfusion injury, apoptosis, and on the development of cardioprotective strategies, diabetic heart failure, peripheral artery disease, and wound healing. She has published almost 180 original peer-reviewed articles, 35 book chapters, and has edited a book related to epigenetics and human disease.