1st Edition

Cardiovascular Diseases Nutritional and Therapeutic Interventions

Edited By Nilanjana Maulik Copyright 2013
    618 Pages 89 B/W Illustrations
    by CRC Press

    With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases.

    Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect.

    Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.

    Part I: Epidemiological Study of Heart Disease

    Epidemiology of Cardiovascular Disease
    Salim S. Abunnaja and Juan A. Sanchez

    Part II: Epigenetic Modifications in Arterial and Heart Diseases

    Epigenetics of Atherosclerosis: Current Insights and Future Perspectives
    Lucia Migliore and Maria Grazia Andreassi

    Genetic and Epigenetic Basis of Myocardial Ischemia and Reperfusion Injury: Protection by Dietary Antioxidants and Chromatin-Modifying Compounds
    Tom C. Karagiannis, Katherine Ververis, and Paul V. Licciardi

    Attenuation of Myocardial Ischaemia-Reperfusion Injury by Probiotic Bacteria
    Paul V. Licciardi, Katherine Ververis, Zheng Q. Toh, and Tom C. Karagiannis

    Part III: Cardiovascular Disease

    Lipid Regulation of Cardiac Ion Channels in Heart Disease
    Lixia Yue, Zhichao Yue, and Jia Xie

    Arginine, Tetrahydrobiopterin, and Nitric Oxide in Myocardial Protection
    Murugesan Velayutham, Lawrence J. Druhan, and Arturo J. Cardounel

    Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury
    Tuanzhu Ha, Li Liu, Jim Kelley, David Williams, and Chuanfu Li

    Aging, Nutrients, and Endogenous Stem Cell Populations
    Ewa K. Zuba-Surma, Harold Elias, and Buddhadeb Dawn

    Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis
    Hongyan Zhu and Guo-Chang Fan

    Doxorubicin-Induced Cardiomyopathy and Benefits from Vitamin C
    Ana Ludke, Gauri Akolkar, Gunjan Bajpai, Neelam Khaper, and Pawan K. Singal

    Hypoxic Preconditioning of Stem Cells to Treat Myocardial Infarction
    Simi M. Chacko and Periannan Kuppusamy

    Diabetes-Associated Cardiomyopathy and Cell Therapy
    Edith Hochhauser, Michael Morozov, and Michael Arad

    Part IV: Nutritional and Other Therapeutic Interventions for CVD

    Pluripotent Stem Cell Therapy for Cardiac Regeneration
    Kiwon Ban, Jaemin Byun, Sangsung Kim, Sukwon Koh, and Young-Sup Yoon

    Nanotechnology and Cardiovascular Diseases
    Kannan Badri Narayanan and Natarajan Sakthivel

    Heart-Healthy Diet: "The Art and Science of Perfecting the Plate"
    S. Sivasankaran

    Nutritional Therapy in the Treatment of Oxidative-Stress-Induced Heart Disease
    Yen-Chun Ho, Meng-Ling Wu, and Shaw-Fang Yet

    Therapeutic Strategies for Metabolic Syndrome and Lifestyle-Related Disease
    Hajime Otani

    Alcohol and Heart Health: Is the Preconditioning Effect of Wine Drinking Related to Alcohol-Induced Changes in Cellular Fatty Acid Profile?
    Joël de Leiris, Stéphane Tanguy, and François Boucher

    Antioxidative Compounds: Description and Evidence of Clinical Relevance
    Thomas F. Whayne, Jr.

    Garlic in Cardiovascular Health: Winnowing the Fact from Artifacts
    Sanjay K. Banerjee and Subir K. Maulik

    Resveratrol Emerges As a Miracle Cardioprotective Phytochemical Polyphenol and Nutraceutical
    Vaithinathan Selvaraju, Mandip Joshi, Sainath R. Kotha, Narasimham L. Parinandi, and Nilanjana Maulik

    Potent Beneficial Effects of Vegetables and Fruits of Cardiovascular Diseases
    Namasivayam Nalini and Jesudoss Victor Antony Santiago

    Phosphodiesterase-5 Inhibitors in Cardioprotection
    Mahesh Thirunavukkarasu and Murugavel Ponnusamy

    Flaxseed and Its Components in Coronary Artery and Peripheral Vascular Disease
    Kailash Prasad

    Flaxseed and Blood Pressure
    Kailash Prasad

    Curcumin and Cardiovascular Diseases
    Sayantan Jana and Snehasikta Swarnakar

    Effect of Fruit and Vegetable Intake on CVD Risk Factors in Humans
    Lars O. Dragsted

    Melon for Cardiovascular Health
    Shubin K. Saha and Sibu P. Saha

    Botanicals as Angiotensin Converting Enzyme Inhibitors Useful in Hypertension
    Pulok K. Mukherjee, Sushil Kumar Chaudhary, Neelesh K. Nema, and B.P. Saha

    Yoga, Meditation, and Healthy Heart: Principles and Evidence
    Sasidharan Bijulal

    Index

    Biography

    Nilanjana Maulik, Ph.D., FAHA, is a professor in the Department of Surgery, University of Connecticut Medical Center, Farmington, Connecticut. She is also a faculty member of the Cell Biology Graduate Program since 2004 at the University of Connecticut Health Center. Professor Maulik’s research focuses on the molecular mechanism of myocardial angiogenesis, ischemia/reperfusion injury, apoptosis, and on the development of cardioprotective strategies, diabetic heart failure, peripheral artery disease, and wound healing. She has published almost 180 original peer-reviewed articles, 35 book chapters, and has edited a book related to epigenetics and human disease.