Emerging Imaging Technologies in Medicine

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ISBN 9781439880418
Cat# K13780



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Cat# KE13929



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  • Provides an overview of the most important emerging medical imaging technologies, modalities, and clinical applications
  • Covers tomosynthesis, breast CT, spectral CT, x-ray phase-contrast imaging, photoacoustic imaging, diffuse optical tomography, and acoustic imaging
  • Presents an overview of the modality, summary of clinical potential, and detailed discussion of the physics and technology
  • Emphasizes a clear understanding of the fundamentals, with a focus on hardware developments
  • Discusses multimodality imaging, including PET/MRI, diffuse optical tomography/MRI, and photoacoustic tomography/diffuse optical tomography as well as three-dimensional microscopy, such as photoacoustic microscopy, optical coherence tomography, and Fourier transform infrared spectroscopy


From the discovery of x-rays in 1895 through the emergence of computed tomography (CT) in the 1970s and magnetic resonance imaging (MRI) in the 1980s, non-invasive imaging has revolutionized the practice of medicine. While these technologies have thoroughly penetrated clinical practice, scientists continue to develop novel approaches that promise to push imaging into entirely new clinical realms, while addressing the issues of dose, sensitivity, or specificity that limit existing imaging approaches.

Emerging Imaging Technologies in Medicine surveys a number of emerging technologies that have the promise to find routine clinical use in the near- (less than five years), mid- (five to ten years) and long-term (more than ten years) time frames. Each chapter provides a detailed discussion of the associated physics and technology, and addresses improvements in terms of dose, sensitivity, and specificity, which are limitations of current imaging approaches. In particular, the book focuses on modalities with clinical potential rather than those likely to have an impact mainly in preclinical animal imaging.

The last ten years have been a period of fervent creativity and progress in imaging technology, with improvements in computational power, nanofabrication, and laser and detector technology leading to major new developments in phase-contrast imaging, photoacoustic imaging, and optical imaging.

Table of Contents

Advancements in Absorption-Based X-Ray Imaging
X-Ray Tomosynthesis
Ingrid Reiser
Spectral/Photon-Counting Computed Tomography
Jochen Cammin, Jan S. Iwanczyk, and Katsuyuki Taguchi

X-Ray Phase-Contrast Imaging
Grating-Based X-Ray Phase-Contrast Imaging
Peter Modregger, Bernd Pinzer, Zhen-Tian Wang, and Marco Stampanoni
Analyzer-Based X-Ray Phase-Contrast Imaging
Jovan G. Brankov and Adam M. Zysk
Propagation-Based Imaging
Glenn R. Myers, Karen K.W. Siu, and Kaye S. Morgan

Photoacoustic Imaging and Tomography
Photoacoustic Mammography
Robert Kruger, Richard Lam, Daniel Reinecke, and Stephen Del Rio
Multiparameter Photoacoustic Tomography
Song Hu, Christopher Favazza, and Lihong V. Wang

Diffuse Optical Imaging
Diffuse Optical Tomography: Imaging Physics and Image Formation Principles
Soren D. Konecky
Diffuse Optical Imaging: Application to Breast Imaging
Paola Taroni, Antonio Pifferi, Giovanna Quarto, Lorenzo Spinelli, Alessandro Torricelli, and Rinaldo Cubeddu
Diffuse Optical Imaging: Application to Brain Imaging
Jeremy C. Hebden

Advances in Acoustical Imaging
Ultrasound Tomography Systems for Medical Imaging
Neb Duric, Olivier Roy, Cuiping Li, Steve Schmidt, Xiaoyang Cheng, Jeff Goll, Dave Kunz, Ken Bates, Roman Janer, and Peter Littrup
Imaging the Elastic Properties of Tissue
Kevin J. Parker
Acoustic Radiation Force Imaging
Jeremy J. Dahl

Multimodality Imaging
Positron Emission Tomography–Magnetic Resonance Imaging
Jinsong Ouyang, Quanzheng Li, and Georges El Fakhri
Multimodal Photoacoustic and Ultrasound Imaging
Peter van Es, Ton G. van Leeuwen, Wiendelt Steenbergen, and Srirang Manohar
Multimodality Imaging: Photoacoustic Tomography/Diffuse Optical Tomography
Adam Q. Bauer, Ralph E. Nothdurft, Todd N. Erpelding, Lihong V. Wang, and Joseph P. Culver
Combined Magnetic Resonance Imaging and Near-Infrared Spectral Imaging
Michael A. Mastanduno, Kelly E. Michaelsen, Scott C. Davis, Shudong Jiang, Brian W. Pogue, and Keith D. Paulsen

Recent Advancements in Three-Dimensional Microscopy
Photoacoustic Microscopy for Ophthalmic Applications
Hao F. Zhang and Shuliang Jiao
Interferometric Synthetic Aperture Microscopy
P. Scott Carney, Steven Adie, and Stephen A. Boppart
Fourier Transform Infrared Spectroscopic Imaging: An Emerging Label-Free Approach for Molecular Imaging
Kevin Yeh, Rohith Reddy, and Rohit Bhargava