Stem Cell Engineering: Principles and Practices

David Schaffer, Joseph D. Bronzino, Donald R. Peterson

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November 20, 2012 by CRC Press
Professional - 221 Pages - 26 B/W Illustrations
ISBN 9781439872048 - CAT# K13309

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Features

  • Covers the temporal evolution of cell differentiation state and overall tissue structure in the early developing embryo as well as some parallels with embryonic stem cell differentiation within embryoid bodies
  • Discusses how mechanical cues regulate cellular processes such as proliferation and migration, as well as highlight parallels for how what has been learned about the mechanobiology of tumors can be applied to stem cells.
  • Describes recent efforts to develop culture systems that can support the indefinite expansion of human embryonic stem cells, potentially by emulating the microenvironment that pluripotent cells experience during their brief window of existence in early embryogenesis.
  • Details a number of important considerations in the application of stem cell therapies to the central nervous system, including cell sources, disease and injury targets, and practical issues associated with cell differentiation and implantation
  • Provides an in-depth analysis of the design of stem cell based cardiac therapies, including sources of resident and exogenous cells, as well as natural and synthetic biomaterials for the differentiation and importantly for the implantation of cells to enhance their viability and engraftment

Summary

While the potential of stem cells is recognized, their proliferation and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell replacement therapies to minimize contamination with residual cells that can give rise to side effects. How can engineers make contributions to address these challenges? With contributions from pioneers and experts, Stem Cell Engineering: Principles and Practices highlights recent advances in the understanding of the cellular and molecular composition of the stem cell niche, as well as approaches to build upon this basic information to direct stem cell differentiation into therapeutically valuable lineages.

The growing recognition of stem cells as an important and exciting field will continue to draw investigators with diverse backgrounds—from biology, engineering, and the physical sciences—and thereby enable further progress in these and other new directions. This book discusses advances made during the last decade that have led to increasingly defined culture systems for growing stem cells, starting from co-culture with feeder cells in the presence of serum to growth on synthetic substrates in defined medium. In addition to highlighting many recent advances, it underscores the need for future work.