1st Edition

Introduction to Natural Products Chemistry

Edited By Rensheng Xu, Yang Ye, Weimin Zhao Copyright 2010
    380 Pages 49 B/W Illustrations
    by CRC Press

    Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry.

    Introduction to Natural Products Chemistry has collected the most important research results of natural product chemistry in China. It overviews the basic principles of isolation, structure, and characteristics of natural products and illustrates current research techniques of structure elucidation with real-life examples of wet chemistry and spectroscopic analyses (UV, IR, MS, and NMR, especially 2d-NMR, HMBC, and HMQC), bioactivity, biosynthesis, and chemical synthesis.

    Specifically, this book covers:

    • Extraction and isolation of natural products
    • Chemistry of fungal products
    • Alkaloids, sesquiterpenoids, diterpenes, and saponins
    • Amino acids and peptides
    • Flavonoids, anthraquinones, coumarins, and lignans
    • Marine natural products
    • Structural modification of active principles from traditional Chinese medicine
    • Chemical synthesis of natural products

    Although natural products chemistry has produced enormous results and made great contributions to human health, industry, and agriculture, only a fraction of natural resources have been rigorously studied. Chinese natural products are a gold mine for further exploration with modern technology and methods. This book represents the continuing collaboration between the fields of natural products chemistry, medicine, biology, and agriculture which will continue to discover and implement novel chemical products from natural sources.

    Introduction, Ren-Sheng Xu

    Extraction and Isolation of Natural Products
    . Ren-Sheng Xu
    Extraction of Natural Products
    Separation of Natural Products
    Concluding Remarks
    Bibliography
    References

    Chemistry of Fungal Products,
    Zhi-Hong Xu
    Introduction
    Bioactive Fungal Metabolites
    Mycotoxins from Fungi
    Isolation and Structure Studies of Fungal Products
    Perspectives
    References

    Alkaloids,
    Ren-Sheng Xu and Yang Ye
    General
    Characterization, Identification and Isolation
    Classification
    Structural Investigations of Some Alkaloids
    Bibliography
    References

    Sesquiterpenoids,
    Zhong-Liang Chen
    Chemical Properties, Isolation and Purification
    Spectroscopic Analysis of Sesquiterpenes
    Artemisinin - Chemistry, Pharmacology, and Clinical Uses
    Recent Progress of Specific Sesquiterpenes
    References

    Diterpenes,
    Zhi-DaMin
    Main Diterpene Skeletons
    Biogenesis
    Labdanes
    Clerodanes
    Pimaranes
    Abietanes
    Cassanes and Totaranes
    Taxanes
    Tiglianes, Ingenanes and Daphnanes
    Jatrophanes and Lathyranes
    Myrsinols and Euphorsctines
    Ginkgolides and Pseudolaric Acid
    References

    Saponins,
    Wei-Min Zhao
    Introduction
    Extraction and Isolation of Saponins
    Structure Determination of Saponins
    Biological Activity of Saponins
    Triterpenoid Saponin
    Steroidal Saponins
    Bibliography
    References

    Amino Acids and Peptides,
    Chang-Qi Hu and Jie-Cheng Xu
    Amino Acids
    Peptides
    References

    Flavonoids,
    De-Yun Kong
    Overview
    Extraction and Isolation of Flavonoids
    Identification and Structure Study of Flavonoids
    Pharmacological Study of Flavonoids
    Flavonoids Assay Determination and Formulation
    Conclusion
    References

    Anthraquinones,
    Yang Lu
    Introduction
    Physical and Chemical Properties
    Extraction and Isolation
    Spectral Characteristics
    Examples
    References

    Coumarins,
    Ze-Nai Chen
    Introduction
    Structural Types
    Physical and Chemical Properties
    Isolation
    Spectroscopic Identification
    Research Example
    References

    Lignans,
    Chang-Qi Hu
    Introduction
    Structural Types and Characteristics of Lignans
    Bioactivities of Lignans
    References

    Other Natural Bioactive Compounds,
    Ren-Seng Xu
    Sulfur Compounds
    Cyanide Compounds
    Coixenolide
    Resveratrol
    Muscone
    Cardiac Glycosides
    Bibliography
    References

    Marine Natural Products,
    Yue-Wei Guo and Wen Zhang
    Introduction
    Marine Plants
    Marine Invertebrates
    Marine Microorganisms and Phytoplankton
    Miscellaneous
    Examples
    Epilogue (Outlook)
    References

    Structural Modification of Active Principles from TCM,
    Da-Yuan Zhu
    Introduction
    Anti-malaria Drug Arthemether
    Anti-hepatitis Drug Bifendate
    Anti-AD Drug Huperzine A
    Antiarrhythmia Drug Changrolin
    Antineoplastic Drugs
    Computer-Aided Drug Design
    References

    Chemical Synthesis of Natural Products,
    Wen-Hu Duan
    Alkaloids
    Terpene
    Flavonoids
    Synthesis of Anthraquinones
    Lignans
    Synthesis of Macrolide Antibiotics
    Bibliography
    References

    Biography

    Ren-Sheng Xu, Professor of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Yang Ye, Professor of Shanghai Institute of Materia Medica, Chinese Academy of Sci□ences. Wei-Min Zhao, Professor of Shanghai Institute of Materia Medica, Chinese Academy of Sciences.