348 Pages 37 Color & 62 B/W Illustrations
    by CRC Press

    Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:

    • X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques
    • Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking
    • Alternative techniques for yielding structural information on carbohydrates from complex biological samples
    • Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection

    Experimental Techniques to Determine Three-Dimensional Structures
    Crystallography and Small-Angle Scattering of Carbohydrate–Protein Complexes and Glycoproteins
    Cy M. Jeffries, William Farrugia, and Paul A. Ramsland
    Nuclear Magnetic Resonance Studies of Carbohydrate–Protein Interactions
    Leonardus M. I. Koharudin and Angela M. Gronenborn
    Electron Cryomicroscopy of Large Glycoprotein Assemblies
    Tzviya Zeev-Ben-Mordehai and Kay Grünewald

    Theoretical/Modeling Techniques to Predict Three-Dimensional Structures
    Protein–Carbohydrate Interactions: Computational Aspects
    Anita Sarkar and Serge Pérez
    Docking of Carbohydrates into Protein Binding Sites
    Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev

    Alternative Approaches for Yielding Detailed Structural Information
    Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins
    Daniel Kolarich and Nicolle H. Packer
    Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins
    Xuezheng Song, David F. Smith, and Richard D. Cummings

    Carbohydrates in Medicine
    Structural Glycobiology: Applications in Cancer Research
    Inka Brockhausen and Yin Gao
    Structural Glycobiology: Applications in Organ Transplantation
    Dale Christiansen, Mark Agostino, Elizabeth Yuriev, Paul A. Ramsland, and Mauro S. Sandrin
    Structural Glycobiology: Applications in Viral Infection
    Rui Xu and Ian A. Wilson
    Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics
    Neha S. Gandhi and Ricardo L. Mancera

    Biography

    Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.

    "… beautifully illustrated with fine color illustrations … valuable for a wide audience - from graduate students to established researchers involved in studies of carbohydrates as well as for specialists in the other fields - biochemists, clinical chemists and immunologists."
    Immunological Investigations, 2013