Basic Pharmacokinetics, Second Edition

Basic Pharmacokinetics, Second Edition

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Features

  • Covers pharmacokinetic concepts from the physiological and biological point of view
  • Explores mathematical quantitative pharmacokinetic relationships
  • Provides practical approaches for applying pharmacokinetic concepts such as physiological pharmacokinetic modeling, multicompartment modeling, and pharmacokinetic/pharmacodynamic modeling
  • Explores clinical pharmacokinetics in chapters on therapeutic drug monitoring, drug-drug interactions, pharmacokinetics in special populations, and pharmacogenetics
  • Presents practice problems and solved examples for test assimilation
  • Includes a companion CD-ROM with interactive computer-based presentations and simulations

Summary

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters.

After a basic introduction to pharmacokinetics and its related fields, the book examines:

  • Mathematical operations commonly used in pharmacokinetics
  • Drug distribution and clearance and how they affect the rate of drug elimination after a single dose
  • Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence
  • The steady-state concept during constant rate intravenous infusion and during multiple drug administration
  • Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion
  • Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling
  • Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics

Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

Table of Contents

Introduction to Pharmacokinetics
Review of Mathematical Fundamentals
Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Distribution
Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Clearance
Drug Pharmacokinetics Following a Single IV Bolus Administration: The Rate of Drug Elimination
Drug Absorption Following Extravascular Administration: Biological, Physiological, and Pathological Considerations
Drug Absorption Following Extravascular Administration: Molecular and Physicochemical Considerations
Drug Absorption Following Extravascular Administration: Formulation Factors
Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption
Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption
Bioequivalence
Drug Pharmacokinetics during Constant Rate IV Infusion: The Steady-State Principle
Steady State during Multiple Drug Administration
Renal Drug Excretion
Metabolite Pharmacokinetics
Nonlinear Pharmacokinetics
Multicompartment Pharmacokinetic Models
Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusion
Pharmacokinetic-Pharmacodynamic Modeling
Noncompartmental Approach in Pharmacokinetic Data Analysis
Physiological Approach to Hepatic Clearance
Physiologically Based Pharmacokinetic Models
Therapeutic Drug Monitoring
Pharmacokinetics in Special Patient Populations
Pharmacokinetic Drug-Drug Interactions
Pharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability
Applications of Computers in Pharmacokinetics
The Companion CD
Solutions for the Practice Problems
Index

Author Bio(s)

Mohsen A. Hedaya, PharmD, PhD, is a professor at the Faculty of Pharmacy at Tanta University in Egypt, and is currently on leave to work at the Faculty of Pharmacy at Kuwait University. His research interests include pharmacokinetic drug interactions, drug delivery to the brain, pharmacokinetic computer simulations, bioequivalent study design and data analysis, and the development and assessment of computer-aided instructional materials in the area of pharmacokinetics. Dr. Hedaya is a member of numerous international scientific associations and has received several prestigious teaching and research achievement awards. He has to his credit extensive scientific publications in national and international journals and frequently gives presentations at national and international scientific meetings. The computer-based educational materials developed by Dr. Hedaya in the area of pharmacokinetics are currently being used by more than 300 educational, research, and industrial institutions around the world.

 
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