The Neurobiological Basis of Suicide

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ISBN 9781439838815
Cat# K11764



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Cat# KE11785



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  • Presents cutting-edge research on the neurobiology of suicide
  • Covers the rapidly growing field of suicide research, including gene expression, microRNA, genetics, epigenetics, and the molecular basis of suicide
  • Discusses how recent neurobiological approaches may transform suicide treatment modalities
  • Addresses neurochemical/neuroanatomical/neuropathological approaches, genetic approaches, intermediate endophenotypes, and epigenetic approaches


With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology.

Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior.

The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Table of Contents

Diagnosis, Traits, States, and Comorbidity in Suicide
Jan Fawcett
Neuroanatomy of Serotonergic Abnormalities in Suicide
Helene Bach and Victoria Arango
Noradrenergic Dysfunction in Depression and Suicide
Michelle J. Chandley and Gregory A. Ordway
Gamma-Aminobutyric Acid Involvement in Depressive Illness: Interactions with Corticotropin-Releasing Hormone
and Serotonin
Hymie Anisman, Zul Merali, and Michael O. Poulter
Role of the Endocannabinoid System in the Neurobiology of Suicide
K. Yaragudri Vinod
Stress–Diathesis Model of Suicidal Behavior
Kees van Heeringen
Do Serum Cholesterol Values and DST Results Comprise Independent Risk Factors for Suicide?
William Coryell
Brain-Derived Neurotrophic Factor in Suicide Pathophysiology
Yogesh Dwivedi
Neuroimaging: High Risk States for Suicide
Jeffrey H. Meyer
Gene–Environment Interaction and Suicidal Behavior
Alec Roy
Genetic Factors and Suicidal Behavior
Clement C. Zai, Vincenzo de Luca, John Strauss, Ryan P. Tong, Isaac Sakinofsky, and James L. Kennedy
Approaches and Findings from Gene Expression Profiling Studies of Suicide
Laura M. Fiori and Gustavo Turecki
Epigenetic Effects of Childhood Adversity in the Brain and Suicide Risk
Benoit Labonté and Gustavo Turecki
Genetics of Suicidal Behavior in Children and Adolescents
Gil Zalsman
Neurobiology of Teenage Suicide
Ghanshyam N. Pandey and Yogesh Dwivedi
Suicidal Behavior in Pediatric Population: Neurobiology and the Missing Links in Assessing Risk among Patients with Bipolar Disorder
Sonali Nannayakkara, Kiran Pullagurla, and Mani Pavuluri
Suicide in Late Life
Olusola A. Ajilore and Anand Kumar
Intermediate Phenotypes in Suicidal Behavior: Focus on Personality
Dan Rujescu and Ina Giegling
Toxoplasma gondii
, the Immune System, and Suicidal Behavior
Olaoluwa Okusaga and Teodor T. Postolache
Peripheral Biomarkers for Suicide
Ghanshyam N. Pandey and Yogesh Dwivedi
Medication in Suicide Prevention: Insights from Neurobiology of Suicidal Behavior
J. John Mann and Dianne Currier

Editor Bio(s)

Yogesh Dwivedi is with the Department of Psychiatry at the University of Illinois.