The Neurobiological Basis of Suicide

Yogesh Dwivedi

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June 25, 2012 by CRC Press
Monograph - 482 Pages - 4 Color & 34 B/W Illustrations
ISBN 9781439838815 - CAT# K11764
Series: Frontiers in Neuroscience

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Features

  • Presents cutting-edge research on the neurobiology of suicide
  • Covers the rapidly growing field of suicide research, including gene expression, microRNA, genetics, epigenetics, and the molecular basis of suicide
  • Discusses how recent neurobiological approaches may transform suicide treatment modalities
  • Addresses neurochemical/neuroanatomical/neuropathological approaches, genetic approaches, intermediate endophenotypes, and epigenetic approaches

Summary

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology.

Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior.

The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.