Neuropeptides in Neuroprotection and Neuroregeneration

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ISBN 9781439830628
Cat# K11501



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Cat# KE11386



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  • Focuses on the latest design and development of new medicines for neuroprotection and neuroregeneration
  • Covers oxidative stress, peptidomimetics, and cognitive enhancement
  • Clarifies the basic molecular mechanisms of the neuronal and nitropeptidergic processes that are important in cognition
  • Collects recent knowledge on the most important peptides involved in neuroprotection


Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration.

The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers:

  • General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors
  • Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology
  • Neuropeptides known for their impact in neurodegenerative and neuroprotective processes
  • Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

Table of Contents

The Neuropeptide Systems—Some Basic Concepts
Tomas Hökfelt, Zhi-Qing David Xu, Tiejun Shi, Csaba Adori, Kang Zheng, Swapnali Barde, and Mingdong Zhang
Neuropeptide Biosynthesis
Margery C. Beinfeld
Neuropeptide Degradation Related to the Expression of Physiological Action of Neuropeptide
Chikai Sakurada, Hirokazu Mizoguchi, Takaaki Komatsu, Shinobu Sakurada, and Tsukasa Sakurada
Neuropeptides, Isolation, Identification, and Quantitation
Jolanta Kotlinska and Jerzy Silberring
Cellular and Molecular Processes of Neuronal Damage and Protective Mechanisms in Neuroprotection and Neuroregeneration. What General Messages Can We Learn from the Situation after Brain Ischemia?
Gregor Zündorf, Daniel Förster, and Georg Reiser
Dynorphins in Central Nervous System Pathology
Kurt F. Hauser, Pamela E. Knapp, Tatiana Yakovleva, Dineke S. Verbeek, and Georgy Bakalkin
Postnatal Stress Procedures Induce Long-Term Endocrine and Metabolic Alterations Involving Different Proopiomelanocortin-Derived Peptides
Alberto Loizzo, Gabriele Campana, Stefano Loizzo, and Santi Spampinato
Prothymosin α—A Novel Endogenous Neuroprotective Polypeptide against Ischemic Damages Hiroshi Ueda, Hayato Matsunaga, and Sebok K. Halder
Influence of Anabolic Androgenic Steroids on Dynorphinergic Pathways in the Rat Brain
Kristina Magnusson
Angiotensin II Receptors and Neuroprotection
Robert E. Widdop, U. Muscha Steckelings, Claudia A. McCarthy, and Jennifer K. Callaway
PACAP and Cellular Protection: Cellular Protection by Members of the VIP/Secretin Family with an Emphasis on Pituitary Adenylate Cyclase-Activating Polypeptide
Lee E. Eiden
General Strategies of Peptide Synthesis
Aleksandra Misicka
Addressing the Interactions between Opioid Ligands and Their Receptors: Classic and Nonclassic Cases
Luca Gentilucci
Use of Peptides as Drug Leads—A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain
Rebecca Fransson and Anja Sandström
Cognition-Enhancing Peptides and Peptidomimetics
Fred Nyberg and Mathias Hallberg