Mixture Toxicity

Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology

Published:
Content:
Editor(s):
Free Standard Shipping

Purchasing Options

Hardback
$135.95
ISBN 9781439830086
Cat# K11470
Add to cart
eBook (VitalSource)
$135.95 $95.17
ISBN 9781439830093
Cat# KE11363
Add to cart
SAVE 30%
Other eBook Options:
 
 

Features

  • Takes an unusual approach to exposure to and risk assessment by exploring the perspectives of ecotoxicologists, human health specialists, and risk assessors
  • Includes a broad and detailed review of problems related to realistic exposure to pollutants, with special emphasis on exposure to mixtures of toxicants and their combined effects on organisms
  • Presents state-of-the-art information based on in-depth discussions among specialists representing different disciplines and approaches
  • Progresses from coverage of exposure to risk assessment, at each step identifying the special complications that are typically raised by mixtures

Summary

In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment.

The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address:

  • Exposure — how to quantify the amounts of chemicals that may enter the living organism
  • Kinetics, dynamics, and metabolism — how the chemicals enter an organism, travel within the organism, how they are metabolized and reach the target site, and explain development of toxicity with time
  • Toxicity — what are the chemicals’ detrimental effects on the organism
  • Test design and complex mixture characterization — how chemicals interact, how to measure effects of mixtures, and how to identify responsible chemicals
  • Risk assessment — how to assess for risks in humans and the environment

An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.

Table of Contents

Exposure, D.J. Spurgeon, H.R. Pohl, S. Loureiro, H. Løkke, and C.A.M. van Gestel
Toxicokinetics and Toxicodynamics, C. Svendsen, T. Jager, S. Haddad, R.S.H. Yang, J.L.C.M. Dorne, M. Broerse, and P. Kramarz
Toxicity from Combined Exposure to Chemicals, A. Kortenkamp and R. Altenburger
Test Design, Mixture Characterization, and Data Evaluation, M. Jonker, A. Gerhardt, T. Backhaus, and C.A.M. van Gestel
Human and Ecological Risk Assessment of Chemical Mixtures, A.M. J. Ragas, L.K. Teuschler, L. Posthuma, and C.E. Cowan

Glossary
References
Appendix 1: Uncertainty of Concentration and Response Addition
Index

Recommended For You

 
 
Textbooks
Other CRC Press Sites
Featured Authors
STAY CONNECTED
Facebook Page for CRC Press Twitter Page for CRC Press You Tube Channel for CRC Press LinkedIn Page for CRC Press Google Plus Page for CRC Press
Sign Up for Email Alerts
© 2014 Taylor & Francis Group, LLC. All Rights Reserved. Privacy Policy | Cookie Use | Shipping Policy | Contact Us