Introduction to BioMEMS

Introduction to BioMEMS

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ISBN 9781439818398
Cat# K10966

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Features

  • Focuses on the essentials of microfabrication
  • Presents in-depth coverage of the techniques of cell/protein micropatterning
  • Gives a thorough presentation of microfluidics, including theory, designs, and historical perspective
  • Explains how BioMEMS technology can increase the biochemical and biophysical complexity of cell culture microenvironments
  • Discusses how BioMEMS devices can improve fluid handling and increase experimentation throughput
  • Provides a good overall vision of how implantable microdevices have evolved, covering the origin of the field and the newest devices
  • Highlights fundamental concepts and defines them in an extensive glossary
  • Includes over 400 color figures, problem sets, design challenges, and key references
  • Offers downloadable PowerPoint slides for instructors

Summary

The entire scope of the BioMEMS field—at your fingertips
Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms.

Brilliant color presentation
Avoiding the overwhelming details found in many engineering and physics texts, this groundbreaking book—in color throughout—includes only the most essential formulas as well as many noncalculation-based exercises. Important terms are highlighted in bold and defined in a glossary. The text contains more than 400 color figures, most of which are from the original researchers.

Coverage of both historical perspectives and the latest developments
Developed from the author’s long-running course, this classroom-tested text gives readers a vivid picture of how the field has grown by presenting historical perspectives and a timeline of seminal discoveries. It also describes numerous state-of-the-art biomedical applications that benefit from "going small," including devices that record the electrical activity of brain cells, measure the diffusion of molecules in microfluidic channels, and allow for high-throughput studies of gene expression.

Table of Contents

How Do We Make Small Things?
Why Bother Making Things Small?
From Art to Chips
Photolithography
Micromachining
Micromolding
Soft Lithography
Hydrogel Devices
Nanofabrication Techniques
Fabrication Based on Self-Assembly: A "Bottom-Up" Approach

Micropatterning of Substrates and Cells
Interaction between Surfaces and Biomolecules
Surface Engineering
Micropatterns of SAMs
Micropatterns of Proteins
Micropatterns of Cells on Nonbiomolecular Templates
Micropatterns of Cells on Biomolecular Templates

Microfluidics
Why Go Small?
Microscale Behavior of Fluids
Fluids in Electrical Fields
Fluids in Acoustic Fields
Fabrication of Microfluidic Channels
Operation of Microfluidic Channels: Practical Concerns
Droplet Microfluidics
Active Flow Control
Micromixers
Combinatorial Mixers

Molecular Biology on a Chip
The Importance of Miniaturizing Molecular Biology
The Importance of Point-of-Care Diagnostics: Where is Cost Really, Really, Really Important?
Sample Preparation: A Bloody Example
The Problem with Microfluidic Sample Separation
Microfluidic Immunoassays
Chips for Genomics and Proteomics
Electrospray Mass Spectrometry
Biochemical Analysis Using Force Sensors

Cell-Based Chips for Biotechnology
Microfluidic Flow Cytometers
Cell Sorting
Cell Trapping
Microfluidic Cell Culture Laboratories
Gene Expression Cellular Microarrays ("Cellomics")
Micro-Bioreactors
Cells on Microelectrodes
Patch Clamp Chips
Cryopreservation
Assisted Reproductive Technologies
Whole Animal Testing

BioMEMS for Cell Biology
An Enabling Technology: The Hurdles
Cell-Substrate Signaling
Cell-Cell Communication
Cell Migration
BioMEMS for Cellular Neurobiology
Developmental Biology on a Chip
Yeast Biology
Plant Cell Biology
Microfluidics for Studying Cellular Dynamics

Tissue Microengineering
Microscaffolding
Micropatterned Cocultures
Stem Cell Engineering
Morphogenesis

Implantable Microdevices
Dental Implants
Implantable Microelectrodes
Delivery of Soluble Signals into the Body
Microtools for Surgery
Insect Research

Appendix

Index

A Summary and Further Reading appear at the end of each chapter.

Author Bio(s)

Editorial Reviews

"I highly recommend this book for an advanced undergraduate or entry-level interdisciplinary graduate course in BioMEMS. It is well written and produced. The color figures differentiate it from other textbooks in this area and the author has done a thorough job documenting the history and current practices in this rapidly developing field. I plan to use it in my own class."
—Joel A. Kubby, University of California, Santa Cruz, BioMedical Engineering OnLine, 2013

"In this classroom-tested textbook, Folch offers a broad, yet detailed lecture on BioMEMS, sharing information in clear, straightforward language and over 400 excellent color figures. The inclusion of only the most important formulae and thought experiments instead of involved mathematical exercises makes this textbook easily readable and relevant both to entry-level as well as advanced researchers. This also makes Introduction to BioMEMS a perfect guide and an easy-to-use comprehensive textbook for researchers from different science and engineering fields."
—Ali Khademhosseini, Harvard Medical School and MIT, Lab on a Chip, 2013

"For anyone interested in learning more about the basics and applications of BioMEMS, I would give my most enthusiastic and unconditional recommendation to an excellent textbook in the field: Introduction to BioMEMS by Prof. Albert Folch. This textbook provides readers with an excellent balance of detailed descriptions and engaging visuals to describe key developments in BioMEMS technology. Additionally, the author highlights important formulas and explains underlying principles in a simple but thorough manner, which allows readers to gain a more comprehensive understanding of these biomedical devices and their applications. …
I highly recommend Introduction to BioMEMS for students interested in learning more about innovative, state-of-the-art biomedical applications. I believe this textbook is well-suited for students from a variety of backgrounds, as it does a brilliant job of explaining fundamental concepts and ideas. … a valuable resource for instructors, as it contains practical exercises, tips for exams, and many sections that lend themselves to interesting classroom discussions. Ultimately, I believe Introduction to BioMEMS should be considered required reading for any student entering the field of BioMEMS. It can serve as the bible in the field."
—Tony Jun Huang, The Pennsylvania State University, Microscopy and Microanalysis, 2013

"The field has been waiting for a true textbook that provides a practical, historical, authoritative and comprehensive introduction to bioMEMS. It has finally arrived, courtesy of Albert Folch, complete with PowerPoint lectures and thoughtful homework questions. I highly recommend it."
—David J. Beebe, University of Wisconsin–Madison

"A comprehensive, colorful textbook on the important field of bioMEMS. I will definitely recommend to my students!"
—Albert van den Berg, University of Twente

"Dr. Folch’s book is a monumental achievement which brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS. Many working scientists and engineers as well as students will find this book fascinating."
—Mehmet Toner, Helen Andrus Benedict Professor of Bioengineering, Harvard Medical School

"This book successfully integrates microfabrication and the physics of microfluidics with numerous biological applications. It provides a visual feast of images that lead to a comprehensive understanding of many complex concepts. Applications presented range from biomolecules to cells, tissues, and organisms, and are presented in clear, logical steps. It serves as an outstanding text for advanced undergraduates and graduate students, as well as an excellent review for researchers who are new to the field."
—Dr. Fawwaz Habbal, Harvard University

"An excellent, easy-to-ready textbook for everyone who wants to obtain a fundamental understanding of bioMEMS technology and get inspired about micro/nano bioengineering."
—Professor Nikos Chronis, University of Michigan

"With extensive citations of the current literature, explanations that really put the technology in context, clear enunciation of the motivations for miniaturization, and historical perspective, the author has made the material very accessible and clear … . I definitely recommend this textbook for bioengineering students."
—Professor Karen C. Cheung, University of British Columbia