Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging and radiation therapy. This book provides medical physicists and radiation oncologists current and relevant information on Adaptive Radiation Therapy (ART), a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus delivering highly individualized radiation therapy for cancer patients. The book should also benefit medical dosimetrists and radiation therapists.
Adaptive Radiation Therapydescribes technological and methodological advances in the field of ART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into three sections (radiobiological basis, current technologies, and clinical applications), the book covers:
The technology and methodology for ART have advanced significantly in the last few years and accumulated clinical data have demonstrated the need for ART in clinical settings, assisted by the wide application of intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). This book shows the real potential for supplying every patient with individualized radiation therapy that is maximally accurate and precise.
Section I Treatment Planning
Radiobiological Principles for Adaptive Radiotherapy, Joseph O. Deasy and Jeho Jeong
Three- and Four-Dimensional Morphological Imaging for Adaptive Radiation Therapy Planning, Lei Xing, Jianguo Qian, Kihwan Choi, and Tae-Suk Suh
Biological Imaging for Adaptive Radiation Therapy, Robert Jeraj and Matt Nyflot
Biomarkers of Early Response for Adaptive Radiation Therapy, Issam El Naqa, Jeffrey M. Craft, Jung Hun Oh, and Joseph O. Deasy
Treatment Plan Optimization for Adaptive Radiation Therapy, Qiuwen Wu, Justus Adamson, and Qingrong Jackie Wu
Treatment Planning Using Biologically Based Models, Vladimir A. Semenenko and X. Allen Li
Isoeffect Calculations in Adaptive Radiation Therapy and Treatment Individualization, Robert D. Stewart, Joo Han Park, and David J. Carlson
Section II Treatment Delivery
Delivery of Intensity-Modulated Radiation Therapy, Cedric X. Yu
Computed Tomography-Based Image-Guided Radiation Therapy Technology, Uwe Oelfke and Simeon Nill
Non-Computed Tomography–Based Image-Guided Radiation Therapy Technology, David Shepard, Daliang Cao, Jianzhou Wu, Jian-Yue Jin, Chad Lee, and Douglas Miller
Off line Plan Adaptation Strategies, James Balter and Dan McShan
Online Adaptive Correction Strategies for Interfraction Variations, Ergun Ahunbay and X. Allen Li
Intrafraction Variations and Management Technologies, Laura I. Cerviño and Steve B. Jiang
Methods for Real-Time Tumor Position Monitoring and Radiotherapy Tracking, Paul Keall
Quality Assurance in Adaptive Radiation Therapy, Zheng Chang, Jennifer O’Daniel, and Fang-Fang Yin
Section III Clinical Applications
Promises of Functional Imaging for Adaptive Radiation Therapy of Central Nervous System Tumors, Yue Cao
Adaptive Radiation Therapy for Head and Neck Cancer, Lei Dong and David L. Schwartz
Adaptive Radiation Therapy for Breast Cancer, Kristofer Kainz, X. Allen Li, and Julia White
Adaptive Radiation Therapy for Lung Cancer, Jun Lian and Lawrence B. Marks
Adaptive Radiation Therapy for Liver Cancer, An Tai, X. Allen Li, and Laura A. Dawson
Adaptive Radiation Therapy for Prostate Cancer, C.-M. Charlie Ma
Adaptive Radiation Therapy for Gynecologic Cancers, Beth Erickson, Karen Lim, James Stewart, Eric Donnelly, William Small, Anthony Fyles, and Michael Milosevic
Adaptive Radiotherapy for Treatment of Soft-Tissue Sarcoma, Julie A. Bradley, Kristofer Kainz, X. Allen Li, Thomas F. DeLaney, and Dian Wang
The authors have succeeded in creating a single compendium which covers nearly every aspect of this complex subject. There is a great need for such a book given the scope and variety of techniques involved, and the lack of any clear consensus on how to implement adaptive therapy regimes. … It is well laid out, with lots of diagrams, worked examples and case studies as well as referencing all the key documents on the subject. … an excellent one-stop resource for any centre considering implementing adaptive radiotherapy techniques.
—Keri Owen, Scope, December 2011
The breadth of the book is impressive, and the authors of each chapter provide a wealth of up-to-date references making it easy for readers who are interested in exploring certain ART techniques and technologies in more detail … The editor and the authors are to be commended for producing a valuable work on a very dynamic field that offers a chance for meaningful clinical benefits to many patients receiving radiation therapy for a variety of cancer types and clinical indications.
—Moyed Miften, Ph.D., University of Colorado School of Medicine, Medical Physics
The editor and authors are to be commended for putting together this excellent book describing the rationale, technologies, implementation, and future research for adaptive radiation therapy (ART). This topic is very timely as ART is the most logical approach to personalized medicine for cancer patients requiring radiation therapy as a single or combined modality treatment. The book contains a wealth of useful information ranging from practical workflow issues to directions of future research. I recommend this book for medical physicists and radiation oncologists who are interested in clinical practice and research utilizing advanced imaging and radiation therapy technology.
—James C.H. Chu, Ph.D., Professor and Director of Medical Physics, Rush University Medical Center
Dr. Li and his colleagues are to be commended for assembling within a single volume a compendium of recent vast technological progress that advances us towards this paramount goal [of individualized radiation therapy].
—From the Foreword by J. Frank Wilson