Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1: Regulating Mechanisms of Chemical Sensitivity
Features
- Presents the most up to date information on hypersensitivity reactions and chronic diseases
- Draws on clinical work with thousands of patients
- Offers ways to reverse the dysfunction of chronic illness as well as prevent their initial trigger
- Explains newly understood mechanisms of chronic disease and hypersensitivity involving core molecular function
- Integrates aspects of Eastern and Western medicine
Summary
The clinical approaches to the chronic degenerative diseases that drain our resources, and compromise our well-being, have become almost exclusively symptom-focused. The common wisdom is that they are idiopathic with final outcomes to be managed rather than prevented or cured. That they are potentially reversible rarely enters into any discussion between doctor and patient.
A Homeostatic approach to Cure and Prevention for Researchers and Clinicians Working in Toxicology, Immunology, Neurology, and Internal Medicine
Reversibility of Chronic Degenerative Disease and Hypersensitivity, a four-part encyclopedia, offers a much different perspective on chronic degenerative disease, one that disputes the idiopathic label attached to most, as well as the usual fatalistic prognosis. The first volume, Regulating Mechanisms of Chemical Sensitivity, demonstrates that one aspect common to chronic diseases is the disruption of systemic and cellular homeostasis. Environmental pollutants play a large role, along with the contributions of genetic and life style factors, in disrupting the self-regulating mechanisms built into our normally adaptive cells.
"As dyshomeostasis develops in the nervous system, causes should be found and removed before the metabolicinduced tissue changes take place and cause autonomous, irreversible fixednamed diseases to occur. …Single and multiple chemicals in various doses either individually and/or in combinations can cause individual or multiorgan dysfunction of the endocrine system. The astute clinician must be aware of these factors in order to help the patient with hypersensitivity and/or chronic degenerative disease." Chapter 2
Drawing on a vast amount of data and clinical cases attended to by the authors in their own medical practices, this volume examines the complex relation that environmental pollution has with chronic degenerative diseases. It considers its impact on the body’s vast communication networks and what excessive overload does to homeostatic mechanisms.
The authors factor in both general and specific environmental loads and how they alter and trigger genetic and non-genetic responses. Volume 1 begins with an overview of the physiologic basis of homeostasis, exploring various ways that the body deals with toxins and the networks it uses to communicate news of assault and makes provisions for adaptation. The text delves into the connective tissue matrix and considers vascular, neural, endocrine, and immune system responses to a variety of noxious assaults.
"Both innate and acquired immunity can be and are altered in individuals with chemical sensitivity and chronic degenerative disease. …With pollutant overload changes can occur in the lymphatic channels, the lymph nodes, and lymph node egress as well as the lymphatic cells. Changes in mucosal function and the effects of the autonomic nervous system are evident with environmental pollutant overload." Chapter 3
Written by two very knowledgeable clinicians, it brings together research of the highest caliber and provides extensive discussions involving sophisticated biochemical, endocrine, and neural science. The text provides clinicians with the knowledge to understand the triggering and processes of degenerative diseases, so that they might develop more efficient treatment and prevention plans. The book also supplies the knowledge and perspective that can lead research to more effective treatments.
"The ground regulation system consisting of the connective tissue matrix, fibroblast, macrophages, mast cell, leukocyte, end capillary vessel and autonomic nerves, is a global information system for regulating the dynamics of homeostasis in the body. …One’s knowledge of this process must be the guide to move through the onset of early end-stage disease and, eventually, see the manifestations to fixed-named autonomous diseases. It is this knowledge that offers us the greatest potential … for preventing and reversing early homeostatic dysfunction." Chapter 1
Table of Contents
Chapter 1 The Physiologic Basis of Homeostasis
Introduction
Overview of the Dynamics of Noxious Incitant Entry and Fate
The Nature of the Incitant Stimulus
The Nature of the Body’s Homeostatic Response
The Nature of Information Intake and Distribution
Automating the Body—Energy
The Clinical Signs and Symptoms after Chronic Noxious Incitant Entry
The Body’s Communication System—The Ground Regulation System
Anatomical Categories Used in Communication for Regulating Homeostatic Mechanism
Skin and Mucous Membranes
Connective Tissue Matrix
Mechanical Support System (Support Structure)
Communication System Properties
Connective Tissue and Electromagnetic Energy
Molecular Sieve
Latent Free Radical Response
Vascular Function—Homeostasis
Diffusion
Vascular Sieve
Microcirculation
Vascular Tone
Lymphatics
Intravascular Content
Cells
Plasma Proteins
Plasma Lipids
Neurological Aspects of Homeostasis
Pollutant Entry and the Body’s Homeostatic Response to and Fate of the Noxious Stimuli
Total Environmental Load
Total Body Load
The Local Receptors
Local Homeostatic Responses and Information Reception
Matrix Receptor
Adjustment Responses
Local Cell and Matrix Reactions for the Adjustment Response
Regional Homeostatic Adjustment
Central Homeostasic Adjustment
Principles and Facts about Adjustment Responses
Defense System
Redox System Latency
The Early Defense Mechanism
Tissue Response to Local Entry (Initially Sub Inflammatory)
Immune Response
Nonimmune Detoxification in Relation to Homeostasis and the Defense Mechanism
Repair Mechanism—Healing
The Nonspecific Mesenchyme Reaction
Rate of Enzyme and Nutrient Deficiency
Homeostatic Dysfunction Leading to a Disordered Homeostatic Response
Periodic Response
Aperiodic Response
The Specific Mechanisms of Inflammation and Function of Neutrophils and Macrophages
Proinflammatory Cytokines
Interleukin-6
Neurological System Connection with the Connective Tissue Matrix and Inflammation
Summary
References
AMPLIFICATION SYSTEMS: NEUROLOGICAL, IMMUNE, AND ENDOCRINE
Chapter 2 Nervous System
Introduction
Linear and Biphasic Effects of Noxious Stimuli Entry
Receptors
Autonomic Nervous System
Anatomy and Physiology of the Peripheral Autonomic Nervous System
Central Connection of the Autonomic Nervous System with the Hypothalamus
Reflex Pathways
Dysfunction of the Autonomic Nervous System
Denervation Supersensitivity
Law of Denervation
Denervation and Spondylosis: Neuropathic Pain
Neurally Mediated Hypotension and Tachycardia
Neuromuscular Hypotension and Chronic Fatigue
Reflex Sympathetic Dystrophy (Causalgia)
Pollutant Injury to the Eye
Pollutant Injury to the Nervous System of the Eye
Cranial Nerves
Autonomic Nerves
Neurogenic Vascular Responses to Pollutant Stimuli
Pathogenesis of Neuroimmunological Mediators (Neuropeptide Triggering by Noxious Stimuli)
The Acupuncture Energy Flow System (AES)
NAET
Voluntary Central Nervous System
Noxious Injury to the Blood-Brain Barrier
Noxious Injury after Penetration of the Blood-Brain Barrier
General Principles of Neuronal Physiology
Principles of Response after Toxic Exposure
Reversibility vs. Irreversibility of Cell Damage after Pollutant Exposure
Mechanism of Acute Central Nervous System Injury
Neurological Effects of Toxic Chemicals
Fixed-Named Disease
Toxic Neuropathy
Summary
References
Chapter 3 Immune System
Introduction
Properties of Entering Noxious Excitants
Stem Cells
Lymph Nodes, Lymphatic Organs, and the Lymphatic System
Development of Lymphatic Channels and Lymphocytes
Regionalization of the Immune Response by Lymphatic Tissue Nodes and Channels after Mucosal Entry
Mucosa Associated Lymphoid Tissue (MALT); Nasal Associated Lymphoid Tissue (NALT); Bronchial Associated Lymphoid Tissue (BALT); Gut Associated Lymphoid Tissue (GALT)
Neuroimmune Regulation
The Clinical Implications of Food and Chemical Sensitivity in Relation to the Autonomic Nervous System and Immune System
Immunity
Innate Immunity
Transition to Innate and Humoral Immunity in the Newborn and Infant
Acquired Immunity
Lymphocytes
The T-lymphocytes
General Intrinsic Mechanisms
B-Lymphocytes
Onset of Antibodies
Classes of Antibodies
Inflammatory Effects
Clinical Regulation of the Immune System
The Cell Cycle
Abnormal Cell Cycle Progression in Patients with Chronic Fatigue Syndrome (CFS)
Cell Cycle and Cancer
Autoimmunity
Failure of the Tolerance Mechanism Causes Autoimmune Diseases
Autogenous Lymphocytic Factor (ALF)
Cell Death
Allergy and Hypersensitivity
Aging and the Immune System
Summary
References
Chapter 4 Endocrine System
Introduction
Integrated Physiology
Pituitary Gland
Pollutant Effects on the Nervous System of the Pituitary Gland
Pollutant Effects on the Physiology of the Pituitary
Growth Hormone
Pineal Gland
Neuroendocrine System (Paraganglia, Paraneuron)
Neuroendocrine Phenotype
Biosynthetic Profile
Secretory Granules
Specialization of Neuroendocrine Cells
Topography of Neuroendocrine Cell Subsets
Branchiomeric Group
Intravagal Neuroendocrine Cells
Visceral-Autonomic Paraganglion Cells
Genitourinary Paraganglion Cells
Paragangliomas
Clinical Manifestations of Neuroendocrine Stimulation
Adrenal Glands
Physiology of the Dynamics of Homeostasis and Dyshomeostasis in the Adrenal Glands
Clinical Picture of Pollutant Injury and Adrenal Dysfunction
Hyperadrenalism
Adrenal Insufficiency/Hypoadrenalism
Parathyroid Gland
Ovary
Organization/Activation Hypothesis
Male Homosexuality
Sexual Dysfunction
Uterus and Tubes
Premenstrual Syndrome
Vasculitis of the Reproductive System
Endometriosis
Spontaneous Abortion
Hormones
The Influence of Toxics on Hormonal Homeostasis
PCBs
Pesticides/Herbicides
Menopause Dysfunction
Vagina and Vulva
Testes and Seminal Vesicles
Mechanisms of Action and Fetal Vulnerability
Hormones and Neurobehavioral Effect
Beyond Endocrine Disruption
Implications and Ongoing Activities
Exogenous Estrogens
Phytoestrogens
Estrogens in Milk
Estrogenic Chemicals
Sertoli Cell Number and Sperm Output
Thyroid
Physiology and Pathophysiology
Agents Acting Directly on the Thyroid
Class I
Class II
Class III
Class IV
Class V
Agents Acting Indirectly on the Thyroid
General Properties, Distribution, and Epidemiology
Sulfurated Organics Thiocyanate (SCN), Isothiocyanates, and Thioglycosides (Goitrin)
Aliphatic Disulfides
Polyphenols
Phenolic and Phenolic-Carboxylic Derivatives
2,4-DNP
Phthalate Esters and Phthalic Acid Derivatives: DHBAs
PCBs and PBBs
PAH, 3,4,-BaP, MCA, and 7,12-DMBA
Summary
References
