An Introduction to Biomaterials, Second Edition

An Introduction to Biomaterials, Second Edition

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Features

  • Covers wound healing biology and host response to implanted biomaterials
  • Examines the regulatory process, including standardized product testing
  • Reviews the innovativeness of biomaterials, with inventorship and patents in mind
  • Considers experimental design, basic scientific methods, and statistics
  • Includes extensive references for further study
  • Contains end-of-chapter questions and answers

Solutions manual available upon qualifying course adoption

Summary

A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property.

Divided into four sections (Biology, Biomechanics, Biomaterials Interactions; Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property; Biomaterials Compositions; and Biomaterials Applications), this dramatically revised edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cell-cell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, new U.S. FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure.

With nine completely new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data, this comprehensive introduction discusses 13 important classes of biomaterials, their fundamental and applied research, practical applications, performance properties, synthesis and testing, potential future applications, and commonly matched clinical applications. The authors include extensive references, to create a comprehensive, yet manageable didactic work that is an invaluable desk references and instructional text for undergraduates and working professionals alike.

Table of Contents

Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences, J.O. Hollinger

Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology

Cutaneous Wound Pathobiology: Raison d’etre for Tissue Engineering, L.K. Macri and R.A.F. Clark
Osseous Wound Healing, A. Nawab, M. Wong, D. Kwak, L. Schutte, A. Sharma, and J.O. Hollinger

Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics

Cell and Tissue Mechanobiology, W. Guo, P. Alvarez, and Y. Wang

Biology, Biomechanics, Biomaterial Interactions: Materials–Host Interactions

Cell–Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations, G.M. Harbers and D.W. Grainger
Host Response to Biomaterials, D.J. Holt and D.W. Grainger
Protein Adsorption at the Biomaterial–Tissue Interface, P. LeDuc, L. Gonzalez, B.M. Rauck, and Y. Wang

Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing

In Vitro Testing of Biomaterials, J. Kim, A. Srinivasan, and J.O. Hollinger
Assessment of Biomaterials: Standardized In Vivo Testing, V.P. Raut, T.E. Patterson, J.C. Wenke, J.O. Hollinger, and G.F. Muschler

Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics

Basic Principles of Statistics: Considerations for Biomaterials Engineers, R.T. Rubin, J. McKlveen, A.S. Fultz, and M.E. Rhodes
Therapy Development, Animal Testing, and Regulatory Issues, C.E. Hart, M. Citron, A. Loewen-Rodriguez, and J.O. Hollinger
Fundamentals of Patenting for the Biomaterials Scientist, E.M. Douglas, Esq.

Biomaterials Compositions

Proteins and Amino Acid–Derived Polymers, J.C. Haarer, B.D. Inskeep, and K.C. Dee
Three-Dimensional Fibrin Constructs in Tissue Engineering, B. Tawil and B. Wu
The Poly(α-esters), D.D. Jamiolkowski and E.J. Dormier
Biomedical Polyurethanes, M. Szycher
Polymers Derived from l-Tyrosine, J. Kohn, A. Darr, and J. Schut
Poly(propylene Fumarate), X. Shi, A. Henslee, D. Yoon, F.K. Kasper, and A.G. Mikos
Hyaluronan, J.H. Brekke, G.E. Rutowski, and K. Thacker
Complex Polysaccharides: Chitosan and Alginate, F. Rauh, M. Dornish, R. Street, and A.R. Shrivats
Collagen: A Natural Biomaterial for Tissue Engineering, A.H. Reddi and P. Alvarez-Urena
Polyphosphazenes, L.S. Nair, Y.M. Khan, and C.T. Laurencin
Biologically Active Glasses, H.M. Elgendy, D.E. Curtin, and A.El-Ghannam
Silk-Based Biomaterials: Biology, Properties, and Clinical Applications, G. Qin and D.L. Kaplan
Calcium-Based Bioceramics: Biology, Properties, and Clinical Applications, S. Crumlett, B. Singleton, S. Oh, and J.L. Ong

Biomaterials Applications

Tissue Engineering of Skin, H.M. Powell and S.T. Boyce
Polymeric Biomaterials for Drug and Nucleic Acid Delivery, Y. Loo and K.W. Leong
Orthopedic Prostheses and Joint Implants, S. Wang, L. Lu, B.L. Currier, and M.J. Yaszemski
Bone and Biomaterials, S.P. Nukavarapu, J.S. Wallace, H.M. Elgendy, J.R. Lieberman, and C.T. Laurencin
Functional Regeneration of Synovial Joints In Vivo: The Role of Biomaterials and Scaffold Design, C.H. Lee and J.J. Mao
Tissue Engineering, Biomaterials, and the Nervous System, L.E. Kokai, L.Y. Santiago, and K.G. Marra
Ligaments, Biomaterials, and Tissue-Engineering Opportunities, J. Freeman, V.I. Walters, and A.L. Kwansa
Cardiovascular Tissue Engineering and Biomaterials, P.R. Baraniak and W.R. Wagner

Index

Editor Bio(s)

Dr. Jeffrey O. Hollinger graduated from Hofstra University in 1969 and received a dental degree and PhD from the University of Maryland in 1973 and 1981, respectively. In addition, he completed a dental residency program and craniofacial fellowship in the U.S. Army Dental Corps. Since 2000, Dr. Hollinger has been a tenured professor at Carnegie Mellon University (CMU) in the departments of biomedical engineering and biological sciences. He is the director of the Bone Tissue Engineering Center at CMU.

From 1993 to 2000, he was a tenured professor at the Oregon Health Sciences University in the departments of surgery and developmental biology, and he directed the Northwest Wound Healing Center. In 1993 Dr. Hollinger retired from the U.S. Army as a colonel after serving 20 years of active duty. During that period, he was the director of the Army’s Bone Program, as well as the director of the Department of Physiology and Biochemistry at the U.S. Army Institute of Dental Research at the Walter Reed Army Medical Center in Washington, DC. He has over 35 years of experience in bone regeneration using biological factors, biomaterials, and preclinical animal models.

Dr. Hollinger has received numerous federal grants as the principal investigator (NIH, NSF, DoD, and NIST) focusing on applied and fundamental sciences for bone regeneration and is engaged with several industrial groups emphasizing bone regenerative therapeutics, as well as serving on corporate boards. Dr. Hollinger has several patents and has licensed technology developed in his lab. He received the prestigious Clemson Award in biomaterials in 2008. He has over 250 peer-reviewed publications, abstracts, book chapters, and books.

 
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