Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy.
The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters, leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems.
Through clear descriptions and color images, this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field, the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.
Introduction: Stem Cell Types Overview and Rationale for Labeling for Imaging, Dara L. Kraitchman and Joseph Wu
Human Embryonic Stem Cells, Richard P. Davis, Edouard G. Stanley, and Christine L. Mummery
Mesenchymal Stem Cells from Bone Marrow, Mark F. Pittenger
Hematopoietic Stem Cells, David C. Weksberg, Megan T. Baldridge, Emmanuel J. Volanakis, and Margaret A. Goodell
Adipose-Derived Adult Stem Cells, Deepak M. Gupta, Nicholas J. Panetta, and Michael T. Longaker
Umbilical Cord Stem Cells, Suzanne Kadereit
Induced Pluripotent Stem Cells, Timothy J. Nelson, Satsuki Yamada, Robert J. McDonald, Almudena Martinez-Fernandez, Carmen Perez-Terzic, Yasuhiro Ikeda, and Andre Terzic
Radionuclide Approaches to Imaging Stem Cells and Their Biological Effects on the Myocardium, Fiona See and Lynne L. Johnson
Fluorescence Imaging of Stem Cells In Vivo: Evolving Technologies and Applications, David E. Sosnovik
Ultrasound Imaging Basics, Howard Leong-Poi
MRI Basics and Principles for Cellular Imaging, Lisa M. Gazdzinski, Paula J. Foster, Eddy S.M. Lee, and Brian K. Rutt
X-Ray Imaging Basics, Jochen Cammin and Katsuyuki Taguchi
Radionuclide Cell-Labeling Methods, Rong Zhou and Hui Qiao
Principles of Bioluminescence Imaging and Its Application In Vivo, Maarten A. Lijkwan, Ernst Jan Bos, and Joseph C. Wu
Quantum Dot Labeling Methods, A.B.R. Kontorovich, G.R. Gaudette, M.R. Rosen, P.R. Brink, and I.S. Cohen
Magnetic Resonance Imaging Cell-Labeling Methods, Ali S. Arbab and Joseph A. Frank
Ultrasound Cell-Labeling Methods, Flordeliza S. Villanueva
X-Ray-Guided Delivery and Tracking of Cells, Jeff W.M. Bulte and Aravind Arepally
Multimodality/Fusion Imaging toward Imaging of Structure and Function, Jason M. Criscione, Albert J. Sinusas, and Tarek M. Fahmy
Other Non-Stem Cell Therapies for Cellular Tracking—Inflammatory Cell Tracking, Yijen L. Wu, Qing Ye, Haosen Zhang, T. Kevin Hitchens, and Chien Ho
Bioluminescence, MRI, and PET Imaging Modalities of Stem Cell-Based Therapy for Neurological Disorders, Marcel M. Daadi, Raphael Guzman, and Gary K. Steinberg
Clinical Application of Noninvasive Molecular Imaging in Cancer Cell Therapy: The First Reporter Gene-Based Imaging Clinical Trial, Shahriar S. Yaghoubi and Sanjiv S. Gambhir
Clinical Cardiology Stem Cell Applications, Anthony J. White, Rachel Ruckdeschel Smith, Raj Makkar, and Eduardo Marbán
Musculoskeletal Clinical Applications of Stem Cells, Antonio J. Machado, John A. Carrino, and Lew C. SchonRegulatory Hurdles to Translation, Adrian D. Nunn
Dara L. Kraitchman, VMD, PhD, FACC, is an associate professor in the Department of Radiology and Department of Molecular and Comparative Pathobiology at Johns Hopkins University. Her research interests include noninvasive imaging and minimally invasive treatment of cardiovascular disease.
Joseph C. Wu, MD, PhD, is an associate professor in the Department of Medicine (Cardiology) and Department of Radiology at Stanford University School of Medicine. His research interests include stem cell biology, gene therapy, genomics, and molecular imaging.
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