Parkinson's Disease, Second Edition

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ISBN 9781439807149
Cat# K10361



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    • Includes new chapters on non-motor features of Parkinson’s disease (PD), pathophysiology, pathogenesis, and treatment
    • Uses visual models to simplify difficult-to-understand concepts
    • Emphasizes therapeutics including new drugs, future therapies, and clinical trials
    • Discusses cutting-edge research including gene and stem cell therapy
    • Covers the clinical aspects of the treatment of both motor and non-motor aspects of PD in depth
    • Investigates the genetic aspects of PD, and possible pathophysiologic mechanisms responsible for PD
    • Describes non-pharmacologic treatment measures and quality-of-life issues in PD



    In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, and aspects of the pathophysiology, pathogenesis, and treatment of PD.

    Table of Contents

    James Parkinson
    Jennifer G. Goldman and Christopher G. Goetz
    Parkinson’s Disease: Where Have We Been?
    Lawrence W. Elmer
    Parkinson’s Disease: Where Are We?
    Raúl de la Fuente-Fernández

    Epidemiology of Parkinson’s Disease: An Overview
    Monica Korell and Caroline M. Tanner
    Environmental Toxins and Parkinson’s Disease
    Jason R. Cannon and Timothy J. Greenamyre
    Rural Environment and Parkinson’s Disease
    Daniel Strickland
    Industrial and Occupational Exposures and Parkinson Disease
    Samuel Goldman
    Tetrahydroisoquinolines and Parkinson’s Disease
    Mark S. LeDoux
    Endogenous Neurotoxins in the Pathogenesis and Progression of Parkinson’s Disease
    Shaik Shavali and Manuchair Ebadi

    Overview of the Genetics of Parkinsonism
    Mathias Toft and Zbigniew K. Wszolek
    α-Synuclein and Parkinson’s Disease
    Thomas Gasser
    LRRK2-Associated Parkinson’s Disease
    Jonathan Carr and Soraya BardienParkin-Associated Parkinson’s Disease
    Anne Grünewald and Christine KleinPINK1- and DJ-1-Linked Parkinsonism
    Eng-King Tan
    Genetic and Bioinformatic Tools in Parkinson’s Disease
    Tatiana Foroud and Nathan Pankratz

    Clinical Features of Parkinson’s Disease
    Tremor, Rigidity, and Bradykinesia
    Kelvin L. Chou and Howard I. Hurtig
    Gait Disorders in Parkinson’s Disease
    Yacov Balash, Jeffrey M. Hausdorff, Tanya Gurevich, and Nir Giladi
    Padraig O’Suilleabhain
    Pain in Parkinson’s Disease
    Blair Ford
    Restless Legs Syndrome and Periodic Limb Movements of Sleep
    Bryan T. Klassen and Charles H. Adler
    Fatigue: A Common Comorbidity in Parkinson’s Disease
    Anelyssa D’Abreu and Joseph H. Friedman
    Visual Dysfunction in Parkinson’s Disease
    Robert L. Rodnitzky
    Visuo-Cognitive Dysfunctions in Parkinson’s Disease
    Andrea Antal, Walter Paulus, and Ivan Bodis-Wollner
    Olfactory Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes
    Katerina Markopoulou and Bruce A. Chase
    Insomnia and Excessive Daytime Sleepiness in Parkinson’s Disease
    J.A. Van Gerpen and Pablo Castillo
    REM Sleep Behavior Disorder
    Aleksandar Videnovic and Cynthia L. Comella
    Gastrointestinal Dysfunction in Parkinson’s Disease
    Ronald F. Pfeiffer
    Urological Dysfunction
    Carlos Singer and Henry Moore
    Sexual Dysfunction
    Cheryl Waters and Janice Smolowitz
    Cardiovascular Autonomic Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes
    Valeria Iodice, David Low, Ekawat Vichayanrat, and Christopher J. Mathias
    Disorders of Thermoregulation in Parkinson’s Disease
    Thomas L. Davis
    Respiratory Dysfunction
    Holly Shill
    Depression in Parkinson’s Disease
    Steven P. Wengel, Dennis P. McNeilly, and William J. Burke
    Anxiety and Parkinson Disease
    Jeremy Quickfall, Michael Trew, and Oksana Suchowersky
    Apathy in Parkinson’s Disease
    Howard D. Weiss and Laura Marsh
    Anne L. Barba, B. Kelly Changizi, Donald S. Higgins, Stewart A. Factor, and Eric S. Molho

    Pathophysiology of Parkinson’s Disease
    Animal Models of Basal Ganglia Injury and Degeneration and Their Application to Parkinson’s Disease Research
    Giselle M. Petzinger and Michael W. Jakowec
    Neuroanatomy of Parkinson’s Disease
    Heiko Braak and Kelly Del Tredici-Braak
    Neuropathology of Parkinson’s Disease
    John E. Duda and Dennis W. Dickson
    Neurophysiology of the Motor Disorder in Parkinson’s Disease
    Gaëtan Garraux and Mark Hallett
    Neurochemistry of Parkinson’s Disease: Dopamine
    L. Charles Murrin
    Pathophysiology of Parkinson’s Disease, Neurochemical Pathology: Other Neurotransmitters
    Yoshikuni Mizuno

    Theories of Pathogenesis
    Oxidative Stress
    Casey Cook and Leonard Petrucelli
    Mitochondrial Dysfunction
    Daniel G. Healy and A.H.V. Schapira
    Fabio Blandini
    Roger Kurlan
    Protein Conformational and Metabolic Changes in Parkinson’s Disease
    Kevin St. P. McNaught and C. Warren Olanow
    Cell Death in Parkinson’s Disease
    Shankar Sadasivan, Ané Korff, Ciaran J. Faherty, and Richard Jay Smeyne

    Diagnosis of Parkinson’s Disease
    Differential Diagnosis of Parkinson’s Disease
    Serena W. Hung and Anthony E. Lang
    Neuroleptic-Induced Movement Disorders
    Manuchair Ebadi
    Clinical Diagnostic Criteria for Parkinson’s Disease
    Daniel Tarsy and Laurie Gordon
    Clinical Batteries and Biomarkers in the Diagnosis of Parkinson’s Disease
    Claire Henchcliffe and Un Kang
    Rating Scales
    Kathleen M. Shannon
    MR Imaging of Parkinsonism
    James B. Wood
    Molecular Imaging in Parkinson Disease
    Danna Jennings, David Russell, Ken Marek, and John Seibyl
    Positron Emission Tomography in Parkinson’s Disease
    Silke Appel-Cresswell, R. Nandhagopal, John R. Adams, and A. Jon Stoessl
    Transcranial Ultrasound in Parkinson’s Disease
    Daniela Berg, Bettina Faust, and Alexandra Gaenslen
    In Vivo Molecular Imaging in Parkinson’s Disease
    Sushil K. Sharma and Manuchair Ebadi
    Placebo Effect in Parkinson’s Disease
    Jayasri Srinivasan, Sarah C. Lidstone, Raúl de la Fuente-Fernández, and A. Jon Stoessl
    Treatment of Parkinson’s Disease with Anticholinergic Medications
    Duarte Machado and Bahman Jabbari
    Kelly E. Lyons and Rajesh Pahwa
    MAO-B Inhibitors for the Treatment of Parkinson’s Disease
    John Bertoni
    Catechol-O-Methyltransferase Inhibitors in the Treatment of Parkinson’s Disease
    Mervat Wahba, Theresa A. Zesiewicz, and Robert A. Hauser
    Symptomatic Treatment of Parkinson’s Disease: Levodopa
    John L. Goudreau and J. Eric Ahlskog
    Dopamine Agonists in Parkinson’s Disease
    Joseph Jankovic and Toby C. Yaltho
    Non-Dopaminergic Drugs for Motor Symptoms
    Pierre R. Burkhard and Francois J.G. Vingerhoets
    Stereotactic Ablative Procedures for Intractable Parkinson’s Disease
    Marco Sassi and Michael S. Okun
    Deep Brain Stimulation Surgery
    Ryan J. Uitti, Yashiko Baba, and Robert E. Wharen Jr.
    Neurotransplantation in the Treatment of Parkinson’s Disease
    Penelope Hallett and Ole Isacson
    Role of Physical Therapy in Management of Parkinson’s Disease
    Rose Wichmann
    Speech Therapy in the Treatment of Parkinson’s Disease
    Shimon Sapir, Lorraine Ramig, and Cynthia Fox
    Dysphagia in Parkinson’s Disease
    Lisa A. Newman
    Restorative and Functional Occupational Therapy in Parkinson’s Disease
    Surya Shah
    Neurologic Music Therapy: A Modality to Address the Diverse Needs of People with Parkinson’s Disease
    Sandra L. Holten
    Dance for Persons with Parkinson’s Disease*
    Olie Westheimer
    Pathogenesis of Motor Response Complications in Parkinson’s Disease: "Mere Conjectural Suggestions" and Beyond
    Leo Verhagen Metman and Christina L. Vaughan
    Treatment of Early Parkinson’s Disease
    John C. Morgan and Kapil D. Sethi
    Treatment of Moderate Parkinson’s Disease
    John E. Duda and Matthew B. Stern
    Management of Advanced Parkinson’s Disease
    Grace S. Lin Liang and James W. Tetrud
    Role and Design of Clinical Trials for Parkinson’s Disease
    Andrew Siderowf and Stanley Fahn
    Future Symptomatic Therapy in Parkinson’s Disease
    Ruth Djaldetti, Shlomit Yust-Katz, and Eldad Melamed
    Calcium Influx, Free Radicals, and Aging: A Metabolic Burden Linked to Neuronal Loss in Parkinson’s Disease
    Javier Sanchez-Padilla, Jaime N. Guzman, and D. James Surmeier
    Therapeutic Potential of Exercise in Parkinson’s Disease
    Brian K. Schilling
    Gene Therapy for Parkinson’s: Disease from Bench to Bedside
    Fredric P. Manfredsson, Aaron C. Rising, M. Angela Cenci, Carmen S. Peden, and Ronald J. Mandel
    Translating Stem Cell Biology to Regenerative Medicine for Parkinson’s Disease
    Florian A. Siebzehnrubl and Dennis A. Steindler
    Alternative Drug Delivery in the Treatment of Parkinson’s Disease
    Pierre J. Blanchet
    Economics of Parkinson’s Disease
    Jessica Mastalski, Robert G. Holloway, and Katia Noyes
    Informal Caregiving: An Essential Part of the Team
    Carmen Dyck and Susan M. Calne
    Driving in Parkinson’s Disease
    Ergun Y. Uc
    Evolution and Potential of the National Parkinson’s Organizations: A Brief Overview
    Ruth A. Hagestuen
    Comprehensive Parkinson’s Disease Care in Complex Environments
    Elaine Cohen, Monique Giroux, Ruth A. Hagestuen, and Gladys Gonzalez-Ramos

    Editorial Reviews

    Praise for the First Edition:

    "…an invaluable reference outlining our current understanding of this disease. … contains all the information that any student new to the field requires to develop a thorough understanding of PD. With chapters about everything from epidemiology, to theories of pathogenesis, and back to symptoms and treatment, this book covers the entire range of what we can know about a biological phenomenon, from the molecular, cellular and genetic levels, through to the whole human being and the entire human population. … accessible to both seasoned veterans of Parkinson’s research, looking for the last information in an area outside their direct expertise, and novices, trying to grasp an understanding of the extent of our current knowledge of PD."
    —Elissa M. Strome, Department of Experimental Medical Science, Lund University, Sweden, in the Journal of Chemical Neuroanatomy

    "I would recommend it highly to those with a specialist’s interest in Parkinson’s disease and to more general neurologists who want an accessible, readable guide to diagnosing and treating this disease."
    New England Journal of Medicine

    "… tightly constructed and well organized. It stands out as the most comprehensive volume available on this disorder."

    "A new encyclopedic collection of clinical wisdom … the largest and most comprehensive of several reference books that focus on this illness … masterfully organized."
    Parkinson’s Disease Update