1st Edition

Dermatokinetics of Therapeutic Agents

Edited By S. Narasimha Murthy Copyright 2011
    228 Pages 15 Color & 71 B/W Illustrations
    by CRC Press

    228 Pages 15 Color & 71 B/W Illustrations
    by CRC Press

    Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.

    Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.

    Topics include:

    • Theoretical Models for Dermatokinetics of Therapeutic Agents
    • Drug Delivery Approaches to Modulate Dermatokinetics of Drugs
    • Conventional Methods of Cutaneous Drug Sampling
    • Cutaneous Microdialysis
    • Sampling Substrates by Skin Permeabilization
    • Spectroscopic Techniques in Dermatokinetics Studies
    • Regulatory Perspective of Dermatokinetic Studies

    Introduction to Dermatokinetics
    Skin Tissue and the Extracellular Fluid
    Fate of Therapeutic Agents in Skin
    Distribution of Drugs in the Skin
    Biochemistry of Cutaneous Tissue and Biotransformation of Drugs
    Dermatokinetics of Drugs and Dermatopharmacology
    Dermatokinetics of Drugs and Dermatotoxicology

    Theoretical Models for Dermatokinetics of Therapeutic Agents

    Introduction to Fundamentals of Pharmacokinetics
    Theoretical Models of Dermatokinetics of Drugs
    Two Compartment Model
    Physiologically Based Pharmacokinetic Model

    Drug Delivery Approaches to Modulate Dermatokinetics of Drugs

    Drug Delivery Systems and Dermatokinetics
    Salts, Prodrugs, and Complexes
    Physiological Approaches to Dermatokinetics of Drugs
    Cutaneous Sustained Release Drug Delivery Systems
    Carrier Mediated Drug Delivery Systems
    Physically Mediated Drug Delivery
    Target Deliver to Skin

    Conventional Methods of Cutaneous Drug Sampling

    Introduction to Drug Sampling Techniques and their use in Dermatokinetics Studies of Drugs
    Tape Stripping Method of Drug Sampling
    Skin Biopsy Sampling
    Skin Blister Fluid Sampling

    Cutaneous Microdialysis

    Basics of Cutaneous Tissue Microdialysis and Methods of Probe Calibration
    Probes Used in Cutaneous Microdialysis
    Common Procedural Issues, Troubleshooting, and Optimization Approaches

    Sampling Substrates by Skin Permeablization

    Introduction to Transcutaneous Sampling of Drugs
    Reverse Iontophoresis
    Electroporation Mediated Drug Sampling
    Sonoporesis Mediated Sampling
    Cutaneous Sampling by Microneedles

    Spectroscopic Techniques in Dermatokinetics Studies

    Introduction to Fundamentals of Spectroscopic Techniques Used in Dermatokinetics Studies
    Fluorescence Detection Skin Drug Levels
    ATR FTIR Detection of Drug in Skin
    Raman Spectroscopy

    Dermatokinetics of Gene Therapeutics

    Gene Therapeutics and Cutaneous Gene Therapy
    Pharmacogenetics of Gene Therapeutics in Skin

    Regulatory Perspective of Dermatokinetic Studies

    Skin Bioavailability and Bioequivalence Studies
    FDA Guidelines for Dermatokinetic Studies

    Biography

    S. Narasimha Murthy is an Assistant Professor of Pharmaceutics at the University of Mississippi.