Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models

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ISBN 9781420084573
Cat# 84577



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    • Focuses on the pertinent comparative aspects in the multiple contexts in which laboratory animals are used
    • Includes chapters new to Volume II on animal models in Human Behavior, Parkinson's Disease, Aging and Alzheimer's Disease, Pain Research, Otolaryngological Disorders, Lung Physiology During Anesthesia, Vaccinology, Helicobacter Infection, Biodefense Research, and Hearing Loss and Tinnitus
    • Examines the spontaneous genetic mutants and the genetically modified animal models available within different research areas
    • Presents contributions by international experts in their respective fields
    • Produced with full color throughout the book, with approximately 50 color images


    Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choice of animal species and strains in different research disciplines.

    Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three R’s: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants.

    Table of Contents

    Animal Models, Jann Hau
    Animal Models for Human Behavior, Steven J. Schapiro
    Animal Models for Psychological Disorders, Robert Murison and Anne Marita Milde
    Animal Models in Neuroscience, Jesper Mogensen
    Induced Animal Models of Parkinson’s Disease, G. A. Smith, E. Murphy, S. B. Dunnett, and E. L. Lane
    Animal Models in Aging and Alzheimer’s Disease, Yael H. Edrey and Rochelle Buffenstein
    Animal Models in Pain Research, Klas S. P. Abelson and John V. Roughan
    Animal Models in Pharmacology and Toxicology, Otto Meyer, Ove Svendsen, and Jens Lykkesfeldt
    Animal Models for Otolaryngological Disorders, Mikhail Wadie and Clarence T. Sasaki
    Animal Models of Lung Physiology during Anesthesia, Göran Hedenstierna, Görel Nyman, and Claes Frostell
    Animal Models of Female Reproduction and Fetal Growth and Development, Anthony M. Carter
    Animal Models in Vaccinology, Coenraad F. M. Hendriksen
    Animal Models in AIDS Research, K. Jagannadha Sastry, Pramod N. Nehete, Amy N. Courtney, and Danielle R. Fontenot
    Animal Models for the Study of Helicobacter Infection, Akira Nishizono
    Animal Models in Mycology, Henrik Elvang Jensen
    Animal Models in Biodefense Research, Mark A. Suckow and Patrick Sharp
    Animal Models in Oral Health Sciences, Björn Klinge and Jörgen Jönsson
    Animal Models of Hearing Loss and Tinnitus, Richard Salvi, Edward Lobarinas, Guang-Di Chen, Daniel Stolzberg, and Dalian Ding

    Editorial Reviews

    "[A] valuable reference book, and potentially a course book for undergraduate and graduate laboratory animal science courses. … [T]he text is well organized and well referenced. I would highly recommend this book as a reference text for all scientists using traditional laboratory animal species … ."
    -- Contemporary Topics in Laboratory Animal Science, Vol. 43, No. 5, Sept. 2004

    "Both volumes of this book are well written, user friendly … it fills a current void by collecting together current practices in the scientific use of animals. Each chapter is well referenced and the book would be a valuable addition to the reference collections of animal facilities and research establishments."
    -- Bryan Howard, Animal Welfare, 2004

    "Hau and Van Hoosier have drawn together information of the highest quality … both volumes of this book will be valuable additions to the shelves of any veterinary surgeon involved in the field, either as a named vet or as a member of the multidisciplinary scientific team required in modern biomedical research."
    -- Paul Townsend, The Veterinary Record, May 31, 2003

    "The text is quite easy to navigate using the chapter contents and index. The photographs and tables are clear and well used throughout. …The vast scope of information that this handbook contains is diverse, informative, and quite useful. The strength of these volumes is in their ability to cover a broad range of topics yet in such detail. This set would be an asset to the graduate student and researcher needing an excellent reference manual."
    -- Sandra L. Jex, Animal Lab News, July/Aug 2003