Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers

Published:
July 25, 2008 by CRC Press - 224 Pages
Author(s):
G.O. Evans, A. George Owen and Company, UK

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ISBN 9781420080094
Cat# 80091
 

Features

  • Covers a full range of the discipline, from basic principles to diagnostic evaluation, in a clear and concise manner
  • Provides information on main laboratory animal species with tables of reference values
  • Includes a chapter on bone marrow evaluation containing material on micronucleus tests in genetic toxicology
  • Explores differences in cell counting techniques
  • Contains a chapter on immunotoxicology

    • Summary

    Hematology data from in vivo toxicology studies remains one of  the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials.

    Covering the three main blood cell types – erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics for new entrants to the fields of laboratory animal hematology and toxicology, especially those topics where the rules for human hematology do not always apply. An entire chapter is devoted to immunotoxicology, a scientific discipline that is closely aligned with hematology.

    The text also addresses pre-analytical and analytical variables that affect animal studies, as these play a far more important part when interpreting data in contrast to humans where many of these variables can be well controlled or have less physiological effect. Information has been collated from published papers, textbooks and unpublished data: Readers are provided with key references to encourage further study

    Table of Contents

    Introduction and Developing Areas of Interest
    Hemopoiesis, Blood Cell Types, and Bone Marrow Examination
    Erythrocytes, Anemias, and Polycythemias
    Additional Erythrocytic Measurements
    Iron, Associated Proteins, and Vitamins
    Leukocytes
    Immunotoxicology
    Hemostasis
    Appendices    :
    References for Laboratory Animal Hematology Data
    SI Units and Conversions
    Expectable Ranges
    General Abbreviations
    Some Common Biochemical Abbreviations
    Compounds Causing Reductions and Destruction of Erythrocytes
    Compounds Causing Reductions of Neutrophil Numbers
    Compounds Affecting Numbers, Function, and Aggregation of Platelets
    Leukocyte—Cluster of Differentiation

    Author Bio(s)

    Following several senior positions and 13 years in health service laboratories, G. O. Evans left the post of principal clinical chemist at Birmingham Children’s Hospital, England, to enter the field of laboratory animal toxicology and clinical pathology. He was head of clinical pathology at Wellcome Research Laboratories, Beckenham, England, moving to join Astra Charnwood, and later the two AstraZeneca sites in the United Kingdom as director of clinical pathology.

    Evans is now a director of A. George Owen and Company. He was the editor of and a contributor to a number of chapters of the book Animal Clinical Chemistry: A Primer for Toxicologists. In addition to lecturing at various universities in the UK, he has published over 40 papers on animal clinical pathology and toxicology. Other activities have included membership on the editorial board of the journal Laboratory Animals for over 15 years, and he has served as scientific secretary, chairman, and now is a lifetime honorary member of the Association of Comparative Clinical Pathology, UK.

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