1st Edition

Computational Protein-Protein Interactions

Edited By Ruth Nussinov, Gideon Schreiber Copyright 2009
    344 Pages 74 B/W Illustrations
    by CRC Press

    336 Pages 74 B/W Illustrations
    by CRC Press

    Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design.

    Explores Computational Approaches to Understanding Protein-Protein Interactions

    Outlining fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for the prediction of function. The text provides general chapters that overview the topic and also includes advanced material. The chapters detail the complexity of protein interaction studies and discuss potential caveats.

    Addresses the Next Big Problem in Molecular Biology

    While it is important to predict protein associations, this is a daunting task. Edited by two experts in the field and containing contributions from those at the forefront of research, the book provides a basic outline of major directions in computational protein-protein interactions research at the heart of functional genomics and crucial for drug discovery. It addresses the next big problem in molecular biology: how to create links between all the pieces of the cell jigsaw puzzle.

    Basic Principles of Protein–Protein Interaction, J. Janin
    Low-Resolution Recognition Factors Determine Major Characteristics of the Energy Landscape in Protein–Protein Interaction, I.A. Vakser
    The Molecular Architecture of Protein–Protein Binding Sites, E.J. Sundberg
    Mapping Protein Function by Combinatorial Mutagenesis, G. Pál and S.S. Sidhu
    The Association of Protein–Protein Complexes, G. Schreiber
    Computational Simulations of Protein–Protein and Protein–Nucleic Acid Association, G.V. Pachov, R.R. Gabdoulline, and R.C. Wade
    Computational Design of Protein–Protein Interactions, J.M. Shifman
    Protein–Protein Docking, H. Hwang, B. Pierce, and Z. Weng
    Prediction of Protein Interaction Sites, Y. Ofran
    Predicting Molecular Interactions in Structural Proteomics, I. Kufareva and R. Abagyan
    Rearrangements and Expansion of the Domain Content in Proteins Frequently Increase the Protein Connectivity in the Protein–Protein Interaction Network, I. Cohen-Gihon, R. Sharan, and R. Nussinov
    Intrinsically Disordered Proteins and Their Recognition Functions, V.N. Uversky, M. Fuxreiter, C.J. Oldfield, A.K. Dunker, and P. Tompa
    Identification of Druggable Hot Spots on Proteins and in Protein–Protein Interfaces, D. Beglov, R. Brenke, G.-Y. Chuang, D. Hall, M. Landon, C.H. Ngan, Y. Shen, S. Thiel, B. Zerbe, D. Kozakov, and S. Vajda
    Designing Protein–Protein Interaction Inhibitors, M. Montes
    Index

    Biography

    Ruth Nussinov, Gideon Schreiber