Introduction to Peptides and Proteins

Introduction to Peptides and Proteins

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ISBN 9781420064124
Cat# 64126
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ISBN 9781439882047
Cat# KE14032
 

Features

  • Brings together the most current information on both peptide and protein structure, analysis, and function under one cover
  • Summarizes recent achievements and emerging applications including those in drug development
  • Investigates misfolding as found in prion diseases, miscleavage as found in Alzheimer’s, and mis-sequencing as found with some cancers
  • Closely examines six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes
  • Provides invaluable information on synthesis methods

Summary

Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research.

Introduction to Peptides and Proteins brings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into –

  • Basic peptide and protein science from assembly through degradation

  • Traditional and emerging research methods including those used in bioinformatics and proteomics
  • New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projects

After providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities.

Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer’s, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools.

No longer just the domain of biologists, many key advances in protein research started in physics labs and have involved contributions from a host of fields including statistics, drug development, genetics, and chemical spectroscopy. Introduction to Peptides and Proteins provides researchers across these fields with the thorough foundation needed to explore all the potential that protein research offers.

Table of Contents

Preface

Further Reading

Biography

Introduction to Part 1; Matjaž Zorko

From Building Block to 3-D Structure

Amino Acids; Matjaž Zorko

Noncovalent Interactions; Matjaž Zorko

Structural Organization of Proteins; Matjaž Zorko

Protein Biosynthesis and Posttranslational Modifications

The Biosynthesis of Proteins; Matjaž Zorko

Posttranslational Modifications; Matjaž Zorko

Folding of Proteins

Protein Folding; Matjaž Zorko

Intracellular Sorting of Proteins; Gunnar von Heijne

Protein Degradation

Protein Turnover; Matjaž Zorko

Introduction to Part II; Astrid Gräslund

Purification and Characterization of Proteins; Matjaž Zorko

Crystallography and X-Ray Diffraction Astrid Gräslund

Optical Spectroscopy; Astrid Gräslund

Nuclear Magnetic Resonance (NMR); Astrid Gräslund

Methods to Follow Protein Folding; Astrid Gräslund

Mass Spectrometry; Astrid Gräslund

Chemical Synthesis of Peptides and Proteins; Ülo Langel

Introduction to Part III; Tiit Land

Protein Engineering and Gene Silencing; Ülo Langel

Protein–Ligand Interactions; Ülo Langel

Sequence Analysis and Function Prediction; Tiit Land

Protein Structure Prediction; Tiit Land

Proteomics; Sherry Niessen and Benjamin F. Cravatt

Introduction to Part IV; Ülo Langel

Enzymes; Matjaž Zorko

Nucleic Acid–Binding Proteins; Ülo Langel

Cell Surface Receptors and Signaling; Ülo Langel

Membrane Proteins; Gunnar von Heijne

Antibodies; Ülo Langel

Fibrous Proteins; Ülo Langel

Selected Classes of Bioactive Peptides; Ülo Langel

Introduction to Part V; Ülo Langel and Astrid Gräslund

Misfolding-Based Diseases; Astrid Gräslund

Miscleavage-Based Diseases; Astrid Gräslund

Missequence-Based Diseases; Astrid Gräslund

Peptides and Proteins as Drugs; Ülo Langel

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