Textbook of Drug Design and Discovery, Fourth Edition
Features
- Presents contributions from the world’s leading experts in medicinal chemistry and pharmaceutical research
- Incorporates applied, academic, and industrial medicinal chemistry
- Encompasses more advanced coverage than similar texts
- Includes multiple 3-D structures to explain concepts
Summary
The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, Textbook of Drug Design and Discovery, Fourth Edition describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease.
This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery.
Extensively revised, new topics in the fourth edition include:
- Biostructure-based and ligand-based drug design
- Chemical biology
- Natural products
- Imaging
- Neurotransmitter transporters
- Opioid and cannabinoid receptors
- Hypnotics
- Neglected diseases
- Immunomodulating agents
- Antibiotics
The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design.
Table of Contents
Introduction to Drug Design and Discovery, P. Krogsgaard-Larsen and L. Bunch
Molecular Recognition in Ligand–Protein Binding, T. Liljefors
Biostructure-Based Drug Design, F. S. Jørgensen and J. S. Kastrup
Ligand-Based Drug Design, I. Pettersson, T. Balle, and T. Liljefors
Chemical Biology, K. Strømgaard
Stereochemistry in Drug Design, M. B. Mayo-Martin and D. E. Jane
Natural Products in Drug Discovery, G. T. Carter
Imaging in Drug Discovery and Development, M. Rudin and T. Mueggler
Peptides and Peptidomimetics, M. Cai, V. V. Kulkarni, and V. J. Hruby
Prodrugs: Design and Development, A. Buur and N. Mørk
Metals in Medicine: Inorganic Medicinal Chemistry, H. R. Hansen and O. Farver
Enzyme Inhibitors: Biostructure-Based and Mechanism-Based Designs, R. A. Copeland, R. R. Gontarek, and L. Luo
Receptors: Structure, Function, and Pharmacology, H. Bräuner-Osborne
Ion Channels: Structure and Function, S.-P. Olesen and D. B. Timmermann
Neurotransmitter Transporters: Structure and Function, C. J. Loland and U. Gether
GABA and Glutamic Acid Receptor Ligands, B. Frølund and U. Madsen
Acetylcholine, A. A. Jensen and P. Krogsgaard-Larsen
Histamine Receptors, I. de Esch, H. Timmerman, and R. Leurs
Dopamine and Serotonin, B. Bang-Andersen and K. P. Bøgesø
Opioid and Cannabinoid Receptors, R. P. Clausen and H. S. Hansen
Hypnotics, B. Ebert and K. A. Wafford
Neglected Diseases, S. B. Christensen
Immunomodulating Agents, U. G. Sidelmann
Anticancer Agents, F. Björkling and L. H. Jensen
Antiviral Drugs, E. De Clercq
Antibiotics, P. Herdewijn
Index
Author Bio(s)
Povl Krogsgaard-Larsen is a professor of medicinal chemistry in the Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, at the University of Copenhagen. Kristian Strømgaard is a professor of chemical biology in the Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, at the University of Copenhagen. Ulf Madsen is currently an associate dean in the Faculty of Pharmaceutical Sciences at the University of Copenhagen.
Editorial Reviews
"… figures are relevant and helpful in explaining concepts in the text. The level of detail in the contents of the book makes it especially suitable for academics and advanced students of medicinal chemistry, but may also be of interest to molecular pharmacologists. biochemists, and others of related disciplines."
—Chromatographia
