Neurotoxicology, Third Edition

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ISBN 9781420054873
Cat# 54872



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  • completely revised content with new contributors and new illustrations, including a full-color insert
  • new state-of-the-science technologies
  • new areas of research and alternative model systems
  • up-to-date coverage of epidemiology, model systems, mechanisms of action, assessment of risk, and cellular approaches to neurotoxicology
  • metabolic influences on neurotoxicity
  • role of free radical formation in neurotoxicity
  • interaction between chemicals and trophic factors
  • endocrine disruptors
  • apoptosis in neurotoxicity
  • in vivo brain imaging
  • advances in measuring cognitive function
  • advances in developing quantitative models for neurotoxicology/risk assessment


This new edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease.  It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process. 

Table of Contents

1. Molecular Approaches to Identify Specific Modes of Action for Neurotoxicity In vitro

Ram Ramabhadran, Steven O. Simmons, William R. Mundy

2. Bioinformatic and Computational Approaches for Analysis of Genomics Data in Neurotoxicology Research

Julia M Gohlke, Willard M. Freeman, Kent E. Vrana

3. Neurotoxicology of Barriers in the Developing Brain

Norman R Saunders, Mark D Habgood, Katarzyna M Dziegielewska

4. Thyroid Hormones – Impact on the Developing Brain: Possible Mechanisms of Neurotoxicity

Mary E. Gilbert, R.T. Zoeller

5. Dopaminergic Nerves as Targets for Neurotoxins

Richard M. Kostrzewa, Lucyna Antkiewicz-Michaluk, Francisco Fornai

6. Endocrine Disruption and Senescence: Consequences for Reproductive Endocrine and Neuroendocrine Systems, Behavioral Responses and Immune Function

Mary Ann Ottinger, Emma Lavoie, Karen Dean, Brandon Sitzmann, Michael J. Quinn, Jr.

7. White Fat Tissue, Obesity, and Possible Role in Neurodegeneration

Palaniyandi Ravanan, Christian Lefebvre d’Hellencourt

8. Microglia: Neuroprotective and Neurodestructive Properties

G. Jean Harry

9. The Slice Culture Model: Considerations for Neurotoxicity Assessment

Andrew D. Kraft

10. Design-Based Stereology and Video Densitometry For Assessment Of Neurotoxicological Damage

P. R. Mouton, M. N. Gordon

11. Effect of Neurotoxins on Brain Tissue and Function Revealed Through in vivo MR Imaging and Spectroscopy

Margaret J. Rosenbloom, Edith V. Sullivan, Adolf Pfefferbaum

12. Principles of Behavioral Phenotyping of Neonatal and Adult Mice

S. H. Brunssen, S. S. Moy, G. E. Kissling

Author Bio(s)

G. Jean Harry, Ph.D., is Head of the Neurotoxicology Group at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) and Adjunct Associate Professor at the University of North Carolina (UNC) and Duke University. She obtained an M.S. in PsychoPharmacology from Virginia Commonwealth University (VCU) in 1977 and a Ph.D. in NeuroPharmacology from VCU in 1981. Dr Harry is currently an Associate Editor for Neurotoxicology.

Hugh A. Tilson, Ph.D. received his doctorate in 1971 from the University of Minnesota and postdoctoral training in Pharmacology at Michigan State University. In 2005, Dr. Tilson was named National Program Director for human health research at the Office of Research and Development at the U.S. Environmental Protection Agency. He joined Environmental Health Perspectives as Editor-in-Chief in 2007.