Nanotechnology and Tissue Engineering: The Scaffold

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ISBN 9781420051834
Cat# E51822



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  • Provides background information on the importance of scaffolds in tissue engineering
  • Discusses the structure and functions of the extra-cellular matrix
  • Includes a comprehensive detailing of cell responses to nano-features
  • Offers the contributions of experts with outstanding reputations in the field
  • Summary

    Nanofabrication gives us the ability to mimic biological structures with molecular level precision. Offering a natural progression of topics, Nanotechnology and Tissue Engineering: The Scaffold provides a state-of-the-art account of groundbreaking research in this rapidly emerging area of biomedical engineering.

    Emphasizing the importance of scaffolds, the book details fundamental and advanced aspects of nanofabrication and examines cellular interactions at the nanoscale level. It reviews extracellular matrix structure and function and discusses various nanoscale biological surface modifications that can improve cellular responses. The editors present the most promising nanofabrication techniques, including electrospinning, lithography, and self assembly. Featuring the contributions of pioneering scientists writing about their own research, this cutting-edge volume —

    • Provides background information discussing the emerging importance of scaffolds in tissue engineering
    • Examines tissue engineering as it relates to orthopedic, cardiovascular, neural, and musculoskeletal applications
    • Details cell responses to a number of nanoscale features
    • Delves into microfabrication techniques in scaffold development
    • Presents research on designer self-assembling peptide scaffolds

    This highly comprehensive resource also discusses clinical implications and applications, presenting exciting breakthroughs in neural, vascular, and musculoskeletal tissue engineering with nanostructures. An essential resource, for biomedical engineers working on the frontiers of tissue research, this book brings together current findings and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues.

    Table of Contents

    SECTION I: Importance of Scaffolds in Tissue Engineering

    Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century, F. Yang, W.L. Neeley, M.J. Moore, J.M. Karp, A. Shukla, and R. Langer

    Top–Down Analysis of a Dynamic Environment: Extracellular Matrix Structure and Function, M. Veiseh, E.A. Turley, and M.J. Bissell

    Functions and Requirements of Synthetic Scaffolds in Tissue Engineering, T. Shyam Karande and C. Mauli Agrawal

    Microfabrication Techniques in Scaffold Development, C.J. Bettinger, J.T. Borenstein, and R. Langer


    SECTION II: Effect of Nanostructures on Cellular Responses and Tissue Regeneration

    Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective, B. Ercan and T. Webster

    Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications, D.A. Lee and C.T. Laurencin


    SECTION III: Promising Nanofabrication Techniques to Develop Scaffolds for Tissue Engineering

    Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration, S. Prasad Nukavarapu, S.G. Kumbar, J.G. Merrell, and C.T. Laurencin

    Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites, E. Phay Shing Tan and C. Teck Lim

    Electrospinning Techniques to Control Deposition and Structural Alignment of Nanofibrous Scaffolds for Cellular Orientation and Cytoskeletal Reorganization, J.K. Wise, M. Cho, E. Zussman, C.M. Megaridis, and A.L. Yarin

    Nanolithographic Techniques in Tissue Engineering, B. Moody and G.S. McCarty

    Designer Self-Assembling Peptide Scaffolds for Tissue Engineering and Regenerative Medicine, A. Horii, X. Wang, and S. Zhang


    SECTION IV: Applications of Nanostructured Scaffolds in Biology and Medicine

    Nanotechnologies in Neural Tissue Engineering, V. Mukhatyar, J. Yeh, and R. Bellamkonda

    Nanotechnologies for Cardiovascular Tissue Engineering, K.A. Wieghaus and E.A. Botchwey

    Nanostructures for Musculoskeletal Tissue Engineering, S. Liao, C.K. Chan, and S. Ramakrishna