A review of the latest research on biomedical polymers, this book discusses natural, synthetic, biodegradable and non bio-degradable polymers and their applications. Chapters discuss polymeric scaffolds for tissue engineering and drug delivery systems, the use of polymers in cell encapsulation, their role as replacement materials for heart valves and arteries, and their applications in joint replacement. The book also discusses the use of polymers in biosensor applications. Edited by an expert team of researchers and containing contributions from pioneers throughout the field, the book is an essential reference for scientists and all those developing and using this important group of biomaterials.
Contents
Introduction to polymeric scaffolds for tissue engineering, K Harrison
Introduction
Cells used in Tissue Engineering
The Scaffold Structure
Fabrication Techniques for Tissue Scaffolds
Supercritical Fluid Processing (SCF)
Future Trends
References
Introduction to polymeric drug delivery systems, K Harrison
Introduction: Controlled Drug Release
Mechanisms of Action for Controlled Drug Release
Examples of Controlled Release Delivery Systems
Commonly Used Polymers for Drug Delivery Systems
Polymer Characteristics and Properties
Future Trends
References
Hydrogels in cell encapsulation and tissue engineering, A. Hillel, P. Shah, and J. Elisseeff
Introduction
Structure and Properties of a Crosslinked Hydrogel
Methods to Form a Hydrogel
Application to Cell Encapsulation and Tissue Engineering
Future Trends
Sources of Further Information and Advice
References
Biodegradable polymers for drug delivery systems, G.S. Kwon and D.F. Ferguson
Introduction
Synthetic Biodegradable Block Copolymers: Polyanhydrides, Poly(alkycyanoacrylates), Polyphoshazenes and Poly(phosphoesters)
Biodegradable Polyesters for Drug Delivery
Poly(ethylenimine) (PEI) and Polyethylene Glycol-co-poly(L-lysine)-g-histidine (PEG-co-PLL-g-His)
Synthetic Block Copolypeptides
Future Trends
References
Polymers as replacement materials for heart valves and arteries, D.M. Espino
Introduction
The Cardiovascular System
Replacing Heart Valves
Replacing Arteries
Tissue Engineered Arteries
Summary and Future Trends
Sources of further information and advice
Acknowledgements
References
Ultra-high molecular weight polyethylene (UHMWPE) in joint replacement, F.W. Shen
Introduction
The Structure of UHMWPE
Fabrication of Implants Using UHMWPE
Implant Sterilization
Crosslinking to Improve Implant Wear Properties
Future Trends
Sources of Further Information and Advice
References
Polymers in biosensors, F. Davis and S.P.J. Higson
Introduction
The Development and Format of Biosensors
Polymer Membranes in Biosensors
Polymer Coatings for Biosensors
Conducting Polymers in Biosensors
Redox-Active Polymers in Biosensors
Molecularly-Imprinted Polymers in Biosensors
Summary and Future Trends
Sources of Further Information and Advice
References
Tissue engineering using natural polymers, V.M Correlo, M.E. Gomes, K. Tuzlakoglu, J.M. Oliveira, P.B. Malafaya, J. F. Mano, N.M. Neves, and R.L. Reis
Introduction
Chitosan and Starch-Based polymers in Tissue Engineering
Production of 3D Porous Scaffolds by Extrusion and Injection Moulding with a Blowing Agent
Producing 3D Porous Scaffolds Using Fibre Bonding
Producing 3D Porous Scaffolds by Melt Based Compression Moulding with Particulate Leaching
3D Porous Scaffolds Produced by Freeze-Drying
Particle Aggregation Techniques to Produce 3D Porous Scaffolds
Microwave Processing of 3D Polymeric Scaffolds
Conclusions
References