Biology of the NMDA Receptor

Series:
Frontiers in Neuroscience
Published:
October 29, 2008 by CRC Press - 350 Pages
Editor(s):
Antonius M. VanDongen, Duke University Medical Center, Durham, North Carolina, USA

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Hardback
$169.95
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ISBN 9781420044140
Cat# 44141
 

Features

  • Explores the role of NMDARs in brain development from a circuit perspective, on the single neuron level, and on the synaptic level
  • Examines the role NMDARs play in the pathology of Huntington’s Disease
  • Describes the mechanisms underlying DA–NMDA receptor interactions, particularly in the striatum
  • Provides an overview of NMDAR regulation by serine/threonine and tyrosine phosphorylation, and the cross-talk between these kinase/phosphatase signaling pathways
  • Covers the physiological roles NMDARs play in the mammalian nervous system and the molecular and structural bases of NMDAR activation

    • Summary

    The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

    Table of Contents

    NMDA Receptors and Brain Development, R.C. Ewald and H.T. Cline
    NMDA Receptors and Huntington’s Disease, H.B. Fernandes and L.A. Raymond
    NMDA and Dopamine Diverse Mechanisms Applied to Interacting Receptor Systems, C. Cepeda, V.M. André, E.L. Jocoy, and M.S. Levine
    NMDA Receptors and Alcohol Addiction, D. Ron and J. Wang
    Transcriptional Regulation of NMDAR Expression, G. Bai and P.W. Hoffman
    NMDARs and Translational Control, C.A. Hoeffer and E. Klann
    Regulation of NMDARs by Kinases and Phosphatases, M.W. Salter, Y. Dong, L.V. Kalia, X.J. Liu, and G. Pitcher
    Trafficking and Targeting of NMDARs, R.S. Petralia, R.A. Al-Hallaq, and R.J. Wenthold
    NMDAR-Mediated Calcium Transients in Dendritic Spines, B.L. Bloodgood and B.L. Sabatini
    NMDA Receptors in Drosophila, S. Xia and A.-S. Chiang
    Extracellular Modulation of NMDARs, K. Williams
    Pharmacology of NMDARs, D.T. Monaghan and D.E Jane
    Activation Mechanisms of NMDARs, M.L. Blanke and A M.J. VanDongen
    Presynaptic NMDARs, I.C. Duguid and T.G. Smart

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