Pharmaceutical Dosage Forms and Drug Delivery

Pharmaceutical Dosage Forms and Drug Delivery

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ISBN 9780849392856
Cat# 9285
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Features

  • Provides an integrated understanding of the theory and applications associated with modern pharmaceutical dosage forms
  • Examines the latest developments in the field of pharmaceutics and drug delivery
  • Covers all of the major currently used and novel dosage forms
  • Reviews the principles of biology required to understand how biomaterials can be used as drug delivery vehicles
  • Explores the latest developments in protein and nucleic acid-based therapeutics
  • Summary

    Integrating aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, Pharmaceutical Dosage Forms and Drug Delivery elucidates basic physicochemical principles and their application in the design of dosage forms. The author addresses the relevance of these principles to the biopharmaceutical aspects of drugs. He explores the latest developments in the application of biomaterials, including polymers and biotechnology-based agents, to the development of novel dosage forms.

    The book covers physicochemical principles of dosage design, biopharmaceutical and physiological considerations, types of commonly used pharmaceutical dosage forms, introduction to polymeric biomaterials, protein and nucleic acid-based dosage forms, and novel and targeted drug delivery systems. It highlights the physicochemical parameters used for the design, development, and evaluation of biotechnological dosage forms and describes the biological barriers to drug absorption.

    Containing the right blend of mathematics, equations, diagrams, pictorials, and other pertinent information, this book provides a unified perspective that creates a greater overall understanding of basic science and cutting-edge technology.

    Table of Contents

    Drug Development and Regulatory Process
    Introduction
    Identification of New Therapeutic Molecules
    Preclinical Research
    Formulation Development
    Regulatory Issues
    Pharmaceutical and Formulation Considerations
    Introduction
    Advantages of Pharmaceutical Dosage Forms
    Influential Factors in Dosage Form Design
    Biopharmaceutical and Physiological Considerations
    Introduction
    Drug Transport across a Polymeric Barrier
    Fick’s Laws of Diffusion
    Pore Diffusion
    Matrix (Monolithic)-Type Nondegradable Device
    Biological Membranes and Drug Absorption
    Dissolution Rate and Noyes–Whitney Equation of Dissolution
    Factors Influencing Dissolution Rate
    Complexation and Protein Binding
    Introduction
    Types of Complexation
    Drug Interaction with Plasma Proteins
    Binding Equilibria
    Impact of Plasma Protein Binding on Dosing Regimens

    Chemical Kinetics and Stability


    Introduction
    Rates and Order of Reaction
    Factors Affecting Reaction Kinetics
    Pathways and Prevention of Chemical Decomposition of Drugs

    Interfacial Phenomena


    Introduction
    Liquid Interfaces
    Adsorption at Solid–Gas Interfaces
    Adsorption at Solid–Liquid Interface

    Rheology


    Introduction
    Newtonian Flow
    Non-Newtonian Flow
    Thixotropy

    Disperse System Basics


    Introduction
    Types of Colloidal Systems
    Kinetic Properties of Colloids
    Electrical Properties
    Electrostatic Effect
    Electrical Double Layer
    Stability of Colloids

    Surfactants and Micelles


    Introduction
    Surfactants
    HLB Systems
    Micelles
    Cloud Point
    Pharmaceutical Suspensions
    Introduction
    Classification of Suspensions
    Characteristics of Pharmaceutical Suspensions
    Formulation of Suspensions
    Flocculation and Deflocculation

    Pharmaceutical Emulsions


    Introduction
    Advantages of Emulsion Dosage Forms
    Types of Emulsions
    Roles of Interfacial Free Energy on Emulsification
    Formulations of Emulsions
    Emulsifying Agents

    Pharmaceutical Solutions


    Introduction
    pH and Solubility
    Buffer and Buffer Capacity
    Vehicles
    Types of Solutions
    Dry or Lyophilized Mixtures for Solution

    Tablets


    Introduction
    Types of Tablets
    Tablet Formulation
    Powder Flow and Compressibility
    Manufacturing of Tablets
    Relationship among Disintegration, Dissolution, and Absorption
    Evaluation of Tablets
    Capsules
    Introduction
    Hard Gelatin Capsules
    Soft Gelatin Capsules
    Evaluation of Capsules

    Injectable Dosage Forms


    Introduction
    Isotonicity..
    Parenteral Routes of Administration
    Formulation of Parenteral Products
    Sterilization of Parenteral Products
    Types of Parenteral Dosage Forms
    Evaluation of Injectable Products
    Semisolid Dosage Forms
    Introduction
    Ointments
    Creams
    Gels
    Lotions
    Pastes
    Inserts, Implants, and Devices
    Introduction
    Inserts
    Implants
    Suppositories
    Aerosol Products
    Transdermal Patches

    Pharmaceutical Polymers


    Introduction
    Definitions and Architectures of Polymers
    Polymer Molecular Weight and Weight Distribution
    Biodegradablity and Biocompatibility
    Polymer Solubility
    Block Copolymers
    Intelligent or Stimuli-Sensitive Polymers
    Water-Soluble Polymers
    Bioadhesive/Mucoadhesive Polymers

    Drug Delivery Systems


    Introduction
    Prodrugs
    Soluble Macromolecular Carriers
    Particulate Carrier Systems
    Oral Drug Delivery
    Alternative Routes of Delivery

    Protein-and Peptide-Based Dosage Forms


    Introduction
    Structure of Peptides and Proteins
    Hydrophobicity of Peptides and Proteins
    Solubility of Peptides and Proteins
    Instability of Peptides and Proteins
    Formulation of Proteins and Peptides
    Antibody-Based Therapy and Delivery
    Antigenicity and Immunogenicity

    Biotechnology-Based Dosage Forms


    Introduction
    Genes and Gene Expression
    Gene Silencing
    Classification of Gene-Silencing Technologies
    Gene Therapy
    Each chapter contains Learning Objectives, Review Questions, and a Bibliography.
    Answers to Review Questions
    Index

    Editorial Reviews

    “…Encompasses the latest developments in the application of biomaterials, and various biotechnology-based developments. This integrated approach saves students and teachers from having to consult many texts to gain an overall view of the field. Learning features include chapter reviews and thoroughly explained answers.”

    "This text provides a single source of information covering basic physicochemical properties, pharmaceutical principles, biopharmaceutics, dosage form design, and drug delivery."

    — Kathy D. Webster, Chair of Pharmaceutical Sciences and Professor, Feik School of Pharmacy, University of Incarnate Word, Texas in Pharm Technol, Volume 24, 2008

     

    "The book covers physiochemical principles of dosage design, biopharmaceutical and physiological considerations, types of commonly used pharmaceutical dosage forms, introduction to polymeric biomaterials, protein and nucleic acid-based dosage forms, and novel and targeted drug delivery systems.  Containing the right blend of mathematics, equations, diagrams, pictorials, and other pertinent information, this book provides a unified perspective that creates a greater overall understanding of basic science and cutting-edge technology."

    -- Anticancer Research, Oct. 2008, 28

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