The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.
Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.
Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.
Microbial Drug Resistance: A Historical Perspective, W.C. Summers
Ecology of Antibiotic Resistance Genes, A.A. Salyers, N. Shoemaker, and D. Schlesinger
Global Response Systems that Confer Resistance, P.F. Miller and P.N. Rather
Multidrug Efflux Pumps: Structure, Efflux, and Inhibition, O. Lomovskaya, H.I. Zgurskaya, K.A. Bostian, and Kim Lewis
Mechanisms of Aminoglycoside Antibiotic Resistance, G.D. Wright
Resistance to ß-Lactam Antibiotics Mediated by ß-Lactamases, J.Y. Cha, L.P. Kotra, and S. Mobashery
Target Modification as a Mechanism of Antimicrobial Resistance, D.C. Hooper
Antibiotic Permeability, H. Taber
Genetic Methods for Detecting Bacterial Resistance Genes, A.C. Fluit
The Evolution and Epidemiology of Antibiotic Resistant Pneumococci, C.G. Dowson and K. Trzcinski
Antimicrobial Resistance in the Enterococcus, G.M. Eliopoulos
Methicillin Resistance in Staphylococcus aureus, K.S. Gilmore and M.S. Gilmore
Mechanism of Drug Resistance in Mycobacterium tuberculosis, A.S. Pym and S.T. Cole
Antibiotic Resistance in Enterobacteria, N.H Georgopapadakou
Resistance as a Worldwide Problem, P. Shears
Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings, C.R Friedman and A. Srinivasan
Antibacterial Drug Discovery in the 21st Century, S.J. Projan
"This second edition of Bacterial Resistance to Antimicrobials builds upon the success of the first edition. It expands and brings it up to date. Chapters describe the genetics and different mechanisms of resistance and together successfully cover the resistance problem as it impacts successful treatment of infectious diseases. The writing makes the subject clear and useful even for those who are not in the resistance field, but are interested in learning more about it."
--Stuart B. Levy, M.D.
Author, "The Antibiotic Paradox: How the Misuse of Antibiotics Destroys their Curative Powers" Professor, Tufts University School of Medicine, Boston, Massachusetts
"This book provides a wealth of valuable information for clinicians and scientists about the topic of bacterial resistance to antimicrobials. What I liked most about the book is that the authors who work in diverse settings (academia, industry, and federal agencies) tackled the problem of antibiotic resistance development from different angles: they not only discussed the scientific foundation of this phenomenon but also addressed the social and economic impact of this problem on the population level."
– Christian T.K.-H. Stadtländer, University of St. Thomas, in Microbe, 2008, Vol. 3, No. 10
"This book provides very good coverage of antibacterial resistance...The opening chapters are well-structured, supplying logical subject matter development."
- Andrew Lamb, Society for General Microbiology, Feb. 2009