Features
Discusses regulatory elements, transcription factors, and regulation by mechanisms such as RNAi Covers the increased frequency of gene clusters in subtelomeric regions, their association with matrix attachment regions, and their regulation by global regulators such as LaeA Examines putative pathogenicity factors, identified allergens, and whether the frequency of A. fumigatus as an allergen and pathogen is simply due to its prevalence in the environment Provides a comprehensive analysis of the genomics of the Aspergilli, including species both beneficial and harmful to humans Reviews the medical and agricultural applications as well as the biotechnological aspects
Summary
With high-quality genome sequences for the important and ubiquitous Aspergilli now available, increased opportunities arise for the further understanding of its gene function, interaction, expression, and evolution. The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods provides a comprehensive analysis of the research that reveals the main biological attributes of these species. The co-editors are a particularly proficient and prolific pair with long track records of scientific productivity.
The book sets the stage with a discussion of basic biology, examining the data on the structure of genomes and comparing the genetic map and annotation methodology. It includes a comparison of metabolic abilities among different Aspergillus spp. and other species, then covers areas such as comparative biology, pathogenic properties, and metabolic capabilities of the Aspergilli. The book reviews established techniques and new methodologies for the post-genomic era in Aspergillus spp. It comes with a CD containing color illustrations to supplement the text.
Filling the need for centralized information on a genus that has important economic impacts on agriculture, human health, industry, and pharmacology, the book presents a wide range of data, collected and arranged into one convenient resource. Written by a team of international experts, this is the first in-depth and exhaustive analysis of the genomics of the Aspergilli.
Table of Contents
Genomics of the Aspergilli
An Overview of the Genus
Aspergillus, S
.E. Baker and J.W. Bennett A First Glance into the Genome Sequence of
Aspergillus flavus,
G.A. Payne, J. Yu, W.C. Nierman, M. Machida, D. Bhatnagar, T.E. Cleveland, and R.A. Dean A Comparative View of the Genome of
Aspergillus fumigatus,
N.D. Fedorova, W.C. Nierman, G. Turner, V. Joardar, R. Maiti, M.J. Anderson, D.W. Denning, and J.R. Wortman The
Aspergillus nidulans Genome and a Comparative Analysis of Genome Evolution in Aspergillus,
A. Rokas and J.E. Galagan Aspergillus nidulans Linkage Map and Genome Sequence: Closing Gaps and Adding Telomeres,
J. Clutterbuck and M. Farman The Genome Sequence of
Aspergillus oryzae,
M. Machida Basic Biology of the Aspergilli
Signal Transduction in Aspergilli,
J.-H. Yu and C. d ’Enfert Gene Regulation,
M.X. Caddick and C. Dobson Mitogen-Activated Protein Kinase Pathways in Aspergilli,
G.S. May Gluconeogenic Carbon Metabolism,
M.J. Hynes Amino Acid Supply of
Aspergillus,
O.W. Draht, S. Busch, K. Hofmann, S. Braus-Stromeyer, K. Helmstaedt, G.H. Goldman, and G.H. Braus Endocytosis,
J.C. Sánchez-Ferrero and M.A. Peñalva RNA Silencing in the Aspergilli,
T.M. Hammond and N.P. Keller Hyphal Morphogenesis in
Aspergillus nidulans,
S.D. Harris Cytoskeleton,Polarized Growth,and the Cell Cycle in
Aspergillus nidulans,
R. Fischer, N. Takeshita, and J. Doonan The Nuclear Pore Complex and Transport in
Aspergillus nidulans,
E.A. Espeso and S.A. Osmani Sexual Development in
Aspergillus nidulans,
D.-M. Han, K.-S. Chae, and K.-H Han Aspergillus Transporters,
G. Diallinas Chromatin in the Genus A
spergillus,
C. Scazzocchio and A. Ramón Transposable Elements and Repeat-Induced Point Mutation in
Aspergillus nidulans,
Aspergillus fumigatus, and
Aspergillus oryzae,
A.J. Clutterbuck, V.V. Kapitonov, and J. Jurka Medically Important Aspects of the Genus
Clinical Aspects of the Genus
Aspergillus,
W.J. Steinbach Pathogenicity Determinants and Allergens,
S. Krappmann Mammalian Models of Aspergillosis, A
.K. Zaas and W.J. Steinbach The Emerging Role of Mini-Host Models in the Study of Aspergillosis,
G. Chamilos and D.P. Kontoyiannis Biotechnological Aspects of the Genus
Food Products Fermented by
Aspergillus oryzae,
K. Abe and K. Gomi Aspergillus as a Cell Factory for Protein Production: Controlling Protease Activity in Fungal Production,
M. Braaksma and P.J. Punt Mycotoxin Production and Prevention of Aflatoxin Contamination in Food and Feed,
J. Yu, G. Payne, B.C. Campbell, B. Guo, T.E. Cleveland, J.F. Robens, N.P. Keller, J.W. Bennett, and W.C. Nierman Methods: Techniques and Resources
Microarrays in
Aspergillus Species,
A. Breakspear and M. Momany Chemostats and Microarrays,
M. Gent and K. Lanthaler Advances in Gene Manipulations Using
Aspergillus nidulans, S.A. Osmani, M. Hynes, and B.R. Oakley Fluorescent Labels for Intracellular Structures and Organelles,
B.R. Oakley and X. Xiang Aspergillus at the Fungal Genetics Stock Center,
K. McCluskey Index