The Aspergilli

The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods

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ISBN 9780849390807
Cat# 9080
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ISBN 9781420008517
Cat# E9080
 

Features

  • Discusses regulatory elements, transcription factors, and regulation by mechanisms such as RNAi
  • Covers the increased frequency of gene clusters in subtelomeric regions, their association with matrix attachment regions, and their regulation by global regulators such as LaeA
  • Examines putative pathogenicity factors, identified allergens, and whether the frequency of A. fumigatus as an allergen and pathogen is simply due to its prevalence in the environment
  • Provides a comprehensive analysis of the genomics of the Aspergilli, including species both beneficial and harmful to humans
  • Reviews the medical and agricultural applications as well as the biotechnological aspects
  • Summary

    With high-quality genome sequences for the important and ubiquitous Aspergilli now available, increased opportunities arise for the further understanding of its gene function, interaction, expression, and evolution. The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods provides a comprehensive analysis of the research that reveals the main biological attributes of these species. The co-editors are a particularly proficient and prolific pair with long track records of scientific productivity.

    The book sets the stage with a discussion of basic biology, examining the data on the structure of genomes and comparing the genetic map and annotation methodology. It includes a comparison of metabolic abilities among different Aspergillus spp. and other species, then covers areas such as comparative biology, pathogenic properties, and metabolic capabilities of the Aspergilli. The book reviews established techniques and new methodologies for the post-genomic era in Aspergillus spp. It comes with a CD containing color illustrations to supplement the text.

    Filling the need for centralized information on a genus that has important economic impacts on agriculture, human health, industry, and pharmacology, the book presents a wide range of data, collected and arranged into one convenient resource. Written by a team of international experts, this is the first in-depth and exhaustive analysis of the genomics of the Aspergilli.

    Table of Contents

    Genomics of the Aspergilli


    An Overview of the Genus Aspergillus, S.E. Baker and J.W. Bennett
    A First Glance into the Genome Sequence of Aspergillus flavus, G.A. Payne, J. Yu, W.C. Nierman, M. Machida, D. Bhatnagar, T.E. Cleveland, and R.A. Dean
    A Comparative View of the Genome of Aspergillus fumigatus, N.D. Fedorova, W.C. Nierman, G. Turner, V. Joardar, R. Maiti, M.J. Anderson, D.W. Denning, and J.R. Wortman
    The Aspergillus nidulans Genome and a Comparative Analysis of Genome Evolution in Aspergillus, A. Rokas and J.E. Galagan
    Aspergillus nidulans Linkage Map and Genome Sequence: Closing Gaps and Adding Telomeres, J. Clutterbuck and M. Farman
    The Genome Sequence of Aspergillus oryzae, M. Machida

    Basic Biology of the Aspergilli


    Signal Transduction in Aspergilli, J.-H. Yu and C. d ’Enfert
    Gene Regulation, M.X. Caddick and C. Dobson
    Mitogen-Activated Protein Kinase Pathways in Aspergilli, G.S. May
    Gluconeogenic Carbon Metabolism, M.J. Hynes
    Amino Acid Supply of Aspergillus, O.W. Draht, S. Busch, K. Hofmann, S. Braus-Stromeyer, K. Helmstaedt, G.H. Goldman, and G.H. Braus
    Endocytosis, J.C. Sánchez-Ferrero and M.A. Peñalva
    RNA Silencing in the Aspergilli, T.M. Hammond and N.P. Keller
    Hyphal Morphogenesis in Aspergillus nidulans, S.D. Harris
    Cytoskeleton,Polarized Growth,and the Cell Cycle in Aspergillus nidulans, R. Fischer, N. Takeshita, and J. Doonan
    The Nuclear Pore Complex and Transport in Aspergillus nidulans, E.A. Espeso and S.A. Osmani
    Sexual Development in Aspergillus nidulans, D.-M. Han, K.-S. Chae, and K.-H Han
    Aspergillus Transporters, G. Diallinas
    Chromatin in the Genus Aspergillus, C. Scazzocchio and A. Ramón
    Transposable Elements and Repeat-Induced Point Mutation in Aspergillus nidulans, Aspergillus fumigatus, and Aspergillus oryzae, A.J. Clutterbuck, V.V. Kapitonov, and J. Jurka

    Medically Important Aspects of the Genus


    Clinical Aspects of the Genus Aspergillus, W.J. Steinbach
    Pathogenicity Determinants and Allergens, S. Krappmann
    Mammalian Models of Aspergillosis, A.K. Zaas and W.J. Steinbach
    The Emerging Role of Mini-Host Models in the Study of Aspergillosis, G. Chamilos and D.P. Kontoyiannis

    Biotechnological Aspects of the Genus


    Food Products Fermented by Aspergillus oryzae, K. Abe and K. Gomi
    Aspergillus as a Cell Factory for Protein Production: Controlling Protease Activity in Fungal Production, M. Braaksma and P.J. Punt
    Mycotoxin Production and Prevention of Aflatoxin Contamination in Food and Feed, J. Yu, G. Payne, B.C. Campbell, B. Guo, T.E. Cleveland, J.F. Robens, N.P. Keller, J.W. Bennett, and W.C. Nierman

    Methods: Techniques and Resources


    Microarrays in Aspergillus Species, A. Breakspear and M. Momany
    Chemostats and Microarrays, M. Gent and K. Lanthaler
    Advances in Gene Manipulations Using Aspergillus nidulans, S.A. Osmani, M. Hynes, and B.R. Oakley
    Fluorescent Labels for Intracellular Structures and Organelles, B.R. Oakley and X. Xiang
    Aspergillus at the Fungal Genetics Stock Center, K. McCluskey
    Index

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