Tissue Engineering

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ISBN 9780849390265
Cat# 9026



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ISBN 9781420008333
Cat# E9026



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  • Presents the latest advances in tissue engineering methods, technologies, and applications
  • Includes contributions by leading experts from around the world
  • Discusses properties of stem cells, primary cells, growth factors, and extracellular matrices
  • Focuses on the enabling technologies underlying tissue-engineered devices or used in their development
  • Surveys the latest applications of tissue-engineered structures, devices, and artificial organs
  • Summary

    Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue Engineering disseminates current thinking on the development of engineered tissues.

    Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques. Finally, the book presents synthetic tissues and organs that are currently under development for regenerative medicine applications.

    The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the handbook, Tissue Engineering surveys the latest advances in this relatively young area. The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry. Furthermore, the text includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue engineered devices.

    Table of Contents

    Fundamentals of Tissue Engineering
    Fundamentals of Stem Cell Tissue Engineering, A.I. Caplan
    Growth Factors and Morphogens:Signals for Tissue Engineering, A.H. Reddi
    Extracellular Matrix: Structure, Function, and Applications to Tissue Engineering M.C. Farach-Carson, R.C. Wagner, and K.L. Kiick
    Mechanical Forces on Cells, Y.-T. Shiu
    Cell Adhesion, A.S. Goldstein
    Cell Migration, G. Cheng and K. Zygourakis
    Inflammatory and Immune Responses to Tissue Engineered Devices, J.M. Anderson

    Enabling Technologies

    Polymeric Scaffolds for Tissue Engineering Applications, D.M. Yoon and J.P. Fisher
    Calcium Phosphate Ceramics for Bone Tissue Engineering, P.Q. Ruhé, J.G.C. Wolke, P.H.M. Spauwen, and J.A. Jansen
    Biomimetic Materials, A.J. García
    Nanocomposite Scaffolds for Tissue Engineering, A.S. Mistry, X. Shi, and A.G. Mikos
    Roles of Thermodynamic State and Molecular Mobility in Biopreservation, A. Aksan and M. Toner
    Drug Delivery, C. Becker and A. Göpferich
    Gene Therapy, J.M. Munson and W.T. Godbey
    Tissue Engineering Bioreactors, J.F. Alvarez-Barreto and V.I. Sikavitsas
    Animal Models for Evaluation of Tissue-Engineered Orthopedic Implants, L. Lu, E. Jabbari, M.J. Moore, and M.J. Yaszemski
    The Regulation of Engineered Tissues: Emerging Approaches, K.B. Hellman and D. Smith

    Tissue Engineering Applications

    Bioengineering of Human Skin Substitutes, D.M. Supp and S.T. Boyce
    Nerve Regeneration: Tissue Engineering Strategies, J.B. Recknor and S.K. Mallapragada
    Gene Therapy and Tissue Engineering Based on Muscle-Derived Stem Cells: Potential for Musculoskeletal Tissue Regeneration and Repair, J. Huard, B. Cao, Y. Li, and H. Peng
    Tissue Engineering Applications —Bone, A.B. Celil, S. Guelcher, J.O. Hollinger, and M. Miller
    Cartilage Tissue Engineering, F. Yang and J.H. Elisseeff
    Tissue Engineering of the Temporomandibular Joint, M.E.K. Wong, K.A. Athanasiou, and K.D. Allen
    Engineering Smooth Muscle, Y. Ching Yung and D.J. Mooney
    Esophagus: A Tissue Engineering Challenge, B.D. Ratner, B.L. Beckstead, K.S. Chian, and A.C. Ritchie
    Tissue Engineered Vascular Grafts, R.H. Schmedlen, W.M. Elbjeirami, A.S. Gobin, and J.L. West
    Cardiac Tissue Engineering: Matching Native Architecture and Function to Develop Safe and Efficient Therapy, N. Bursac
    Tissue Engineering of Heart Valves, K.J. Grande-Allen
    Tissue Engineering, Stem Cells and Cloning for the Regeneration of Urologic Organs, J.D. Rackley and A. Atala
    Hepatic Tissue Engineering for Adjunct and Temporary Liver Support, F. Berthiaume, A.W. Tilles, M. Toner, M.L. Yarmush, and C. Chan
    Tissue Engineering of Renal Replacement Therapy, W.H. Fissell and H.D. Humes
    The Bioengineering of Dental Tissues, R.N.D ’Souza and S. Shi
    Tracheal Tissue Engineering, B. Dunham, P. Flint, S. Singhal, C. Le Visage, and K. Leong