Gene and Cell Therapy

Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition

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Features

  • Addresses all aspects of gene and cell therapy
  • Includes fundamental basics as well as state-of-the-art advances
  • Features 12 new chapters covering such topics as tissue engineering, human embryonic stem cells, and nanotechnologies
  • Discusses gene therapy from the perspective of many disciplines, including virology, molecular biology, immunology, chemistry, pharmacology, and other sciences

Summary

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression.

New Topics Covered in this Edition:

  • Gene and Cell Therapies for Diabetes and Cardiovascular Diseases
  • Clinical Trials
  • Human Embryonic Stem Cells
  • Tissue Engineering Combined with Cell Therapies
  • Novel Polymers
  • Relevant Nanotechnologies
  • SiRNA Therapeutic Strategies
  • Dendrimer Technologies
  • Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies.

    The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness.

    The final section discusses recent clinical trials and regulatory issues surrounding the new technology.

    This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.

    Table of Contents

    Delivery Systems and Therapeutic Strategies
    Retroviral Vectors for Cell and Gene Therapy, A. Schambach, T.  Maetzig, and C. Baum
    Production of Retroviral Vectors: From the Producer Cell to the Final Product, P.E. Cruz, A.S. Coroadinha, T. Rodrigues, and H. Hauser
    Adenovirus Vectors for Gene Therapy, N.R. Hackett and R.G. Crystal
    Modified Adenoviruses for Gene Therapy, J.N. Glasgow, A. Hemminki, and D.T. Curiel
    Helper-Dependent Adenoviral Vectors for Gene Therapy, N. Brunetti-Pierri and P. Ng
    Adeno-Associated Virus and AAV Vectors for Gene Delivery, B.J. Carter, H. Burstein, and R.W. Peluso
    Therapeutic Gene Transfer with Replication-Defective Herpes Simplex Viral Vectors, D. Wolfe, W.F. Goins, A. Frampton, M. Mata, D.J. Fink, and J.C. Glorioso
    Oncolytic Viruses for Treatment of Cancer, M. Raki, M. Rajecki, D. Kirn, and A. Hemminki
    Lentiviral Vectors, J.M. Felder III and R. Sutton
    Vaccinia Viral Vectors, J.A. McCart and D.L. Bartlett
    Baculovirus-Mediated Gene Transfer: An Emerging Universal Concept, K.J. Airenne, A.J. Mähönen, O.H. Laitinen, and S. Ylä-Herttuala
    Bacterial Vector in Gene Therapy, M.-S. Dai and G. Vassaux
    Redox-Responsive Polymer-Based Gene Delivery Systems, D. Oupický, Y.-Z. You, and D.S. Manickam
    Polymers and Dendrimers for Gene Delivery in Gene Therapy, I.F. Uchegbu, C. Dufès, P.L. Kan, and A.G. Schätzlein
    Receptor-Targeted Polyplexes for DNA and siRNA Delivery, A. Philipp and E. Wagner
    Electroporation of Plasmid-Based Vaccines and Therapeutics, R. Draghia-Akli and A.S. Khan
    Magnetofection: Using Magnetic Particles and Magnetic Force to Enhance
    and to Target Nucleic Acid Delivery, F. Scherer and C. Plank
    Biolistic and Other Needle-Free Delivery Systems, M.A.F. Kendall
    Optimization of Nonviral Gene Therapeutics, N. Smyth Templeton
    Photochemical Internalization: A Technology for Efficient and Site-Specifi c Gene Delivery, A. Bonsted, A. Høgset, and K. Berg
    Interactions in Macromolecular Complexes Used as Nonviral Vectors for Gene Delivery, R. Podgornik, D. Harries, J. DeRouchey, H.H. Strey, and V.A. Parsegian
    Other Therapeutic Strategies
    In vivo Applications of Morpholino Oligonucleotides, J.S. Isenberg, W.A. Frazier, and D.D. Roberts
    Antisense Oligonucleotide-Based Therapeutics, C.F. Bennett, E. Swayze, R. Geary, L. Tillman, and G. Hardee
    Development of RNAi Therapeutics, A.R. de Fougerolles
    Suicide Gene Therapy, N. Ballian, B.W. O’Malley Jr., and F.C. Brunicardi
    Selectable Markers for Gene Therapy, J.-P. Gillet, C. Kimchi-Sarfaty, S. Shinar, T. Licht, C. Lee, P. Hafkemeyer, C.A. Hrycyna, I. Pastan, and M.M. Gottesman
    Embryonic Stem Cells and Their Application in Regenerative Medicine and Tissue Engineering,.D. Evans and J.M. Polak
    Polymeric Nano- and Microparticles for the Delivery of Antisense Oligonucleotides and siRNA, E. Fattal and G. De Rosa
    Gene Expression and Detection
    Deliberate Regulation of Therapeutic Transgenes, N. Vilaboa and R. Voellmy
    Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies, S. Ray, S. Biswal, and S.S. Gambhir
    Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase,
    and Homologous Recombination Systems, L.E. Woodard and M.P. Calos
    Disease Targets and Therapeutic Strategies
    Hematopoietic Progenitor Cells, K.-Y.K. Lin, O. Sirin, and M.A. Goodell
    Gene Therapy for Hematopoietic Disorders,.M. Kang, M.E. Horwitz, and H.L. Malech
    Use of Genetically Modified Stem Cells in Experimental Gene Therapies, T.P. Zwaka
    Cardiovascular Gene and Cell Therapy, K. Oka
    Gene Therapy for Cancer, K. Brand
    Molecular Therapy for Type 1 and Type 2 Diabetes, S.L. Samson, V. Yechoor, and L. Chan
    Progress toward Gene Therapy for Cystic Fibrosis, R.S. Everett and L.G. Johnson
    Gene Therapy for Neurological Diseases, W.J. Bowers, S. de Silva, and H.J. Federoff
    Principles of Gene Therapy for Inborn Errors of Metabolism, J.A. Wolff and C.O. Harding
    RNA Interference–Based Gene Therapy Strategies for the Treatment of HIV Infection, L. Scherer and J.J. Rossi
    Cutaneous Gene Transfer: Cell and Gene Therapy of Skin and Systemic Disorders, W. Buitrago and D.R. Roop
    Gene Therapy for Childhood Onset Blindness, M.C. Canver and J. Bennett
    DNA Vaccines, J. Yan and D.B. Weiner
    Immunoisolation for CNS Cell Therapy, D.F. Emerich and C.G. Thanos
    Clinical Trials and Regulatory Issues
    Cardiovascular Gene Therapy, J. Tongers, J. Roncalli, and D.W. Losordo
    Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside, G. Dotti, B. Savoldo, F. Okur, R.F. Rousseau, and M.K. Brenner
    p53 Tumor Suppressor Opens Gateways for Cancer Therapy, M.-S. Dai, J.R. Gallegos, and H. Lu
    Recombinant Adenoviral-p53 Agent for Treatment of Cancers, Z. Peng, Q. Yu, and J. Zhu
    Gene Marking Studies of Hematopoietic Cells, C.M. Bollard, S.K. Tey, M.K. Brenner, and H.E. Heslop
    Regulatory Aspects of Gene Therapy, S.L. Simek and L. Bi
    Index

    Editorial Reviews

    Praise for the Second Edition
     ” … this book is the most solid choice out there for sheer breadth and accessibility of information … . It’s hard to imagine anyone doing a better job on content. The editors and authors should be commended.”
    Molecular Therapy

    ” … highly valuable … .”
    Pharmaceutical Research

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