Pharmacological Effects of Ethanol on the Nervous System
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Summary
This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.
Table of Contents
Introduction, R.A. Deitrich and V.G. Erwin
Overview, G. Koob
Section I: Effects of Ethanol at the Molecular/Cellular Level
Cell Membrane Structure, W.G. Wood, F. Schroeder, R.M. Adibhatla, U. Igbavboa, N.A. Avdulov
Calcium Channels, D. Mullikin-Kilpatrick and S.N. Treistman
Chloride Channels/GABA, S.J. Mihic and R. A. Harris
Glutamate Receptors, B. Tabakoff and P.L. Hoffman
Cholinergic Systems, A.C. Collins
Phosphorylation, K. T. Eggeman and M.D. Browning
G-Proteins, F.Y.G. Lee, Sr. and G.S. Wand
Adenosine, T.V. Dunwiddie
Neurotensin, V.G. Erwin
Peptides, G.R. Siggins, Z. Nie, P. Schweitzer, S. Madamba, S.J. Henriksen
Thyrotropin Releasing Hormone, T.J. McCown and G.R. Breese
Section II: Behavioral Effects of Ethanol
Ethanol Intake, H.H. Samson and C.W. Hodge
Initial Sensitivity, L.J. Draski and R.A. Deitrich
Acute Tolerance, A.D. Le and J.M. Mayer
Dependence and Withdrawal, P. Metten and J.C. Crabbe
Ethanol's Acute Effects on Thermoregulation: Mechanisms and Consequences, R. Alkana and A.D. Le
Section III: Toxicity of Ethanol in the Central Nervous System
Free Radicals, R. Nordmann and H. Rouach
Fetal Damage-Mechanisms, W.-J.A. Chen, S.E. Maier, and J.R. West
Structural Damage, M.E. Charness
Neurological Damage and Stroke, M.E. Hillbom
Fetal Damage-Behavior, H.C. Becker
Editorial Reviews
"This is an exciting, useful and affordable book. . . . The editors have done a remarkable job of assembling much of the molecular/cellular, behavioral and chemical aspects of ethanol into some 450 pages."
-Journal of Studies on Alcohol
