Human Growth Hormone Pharmacology: Basic and Clinical Aspects
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Summary
This book addresses a wide range of basic and clinical issues in the physiology and pharmacology of growth hormone. The volume is organized like a textbook. It begins with factors contributing to GH gene expression, the functional relationships of the GH receptor, molecular biological analysis of the GH-GH receptor complex and proceeds to describe the insulin-like growth factor axis. Transgenic models are discussed for analysis of discrete effects. These discussions provide a bridge to clinically oriented discussions of growth abnormalities in GH deficient children, GH insensitivity due to deficiency of the GH receptor, and the concept of aging as a GH/IGF-I deficiency state. Discussions also include the immune system as a source and a responder to GH, GHRH, IGF-I and the effects of GH excess.
Table of Contents
Human Growth Hormone Gene Expression in Pituitary and Placenta, N.E. Cooke and S.A. Liebhaber
Growth Hormone-Prolactin Receptor Gene Family, P.A. Kelly, M. Nagano, A. Sotiropoulos, J.-J. Lebrun, P. Touraine, L. Goujon, H. Dinerstein, F. Ferrag, H. Buteau, A. Pezet, N. Esposito, J. Finidori, M.-C. Postel-Vinay, and M. Edery
Rational Design of Potent Antagonists to the Human Growth Hormone Receptor, A.M. DeVos, M.H. Ultsch, A.A. Kossiakoff, G. Fuh, B.C. Cunningham, and J.A. Wells
The Insulin-Like Growth Factor (IGF) Axis, P. Cohen and R.G. Rosenfeld
Transgenic Mice in the Study of Growth Hormone and the Insulin-Like Growth Factors, A.J. D'Ercole
Clinical Aspects of Growth Hormone Treatment of Children, A.D. Rogol
Growth Hormone Receptor Deficiency, M.A. Vaccarello
Growth Hormone, IGF-I and Human Aging, R. Marcus and A. Hoffman
Effects of Human Growth Hormone in Older Adults, A.A. Abbasi and D. Rudman
Growth Hormone Effects on the Immune System, D.A. Weigent and J. Edwin Blalock
Spontaneous & Iatrogenic Hypersomatotropism, W.H. Daughaday
Author Index
Subject Index
