Malignant Hyperthermia A Genetic Membrane Disease

Part I: Prologue 1. "If Only Dantrolene Had Been Available Then ... " 2. "I Am Punching the Walls. My Hands Are Bleeding. I Want Daniel!" 3. "Why Him? Why Us?" Part II: History of Malignant Hyperthermia Research 4. The Early History of Malignant Hyperthermia — a Personal Perspective 5. The Discovery of Malignant Hyperthermia in Pigs — Some Personal Recollections 6. How was the Abnormal Calcium Release from the Sarcoplasmic Reticulum Identified? Part III: Current Understanding on the Mechanism of Malignant Hyperthermia 7. Clinical Features of Malignant Hyperthermia in Man 8. The Porcine Hyperthermia and Stress Syndromes 9. Canine Malignant Hyperthermia/Canine Stress Syndrome 10. Drug-Induced Hypermetabolic Syndromes 11. Free Calcium Concentration in Skeletal Muscle of Malignant Hyperthermia Susceptible Subjects: Effects of Ryanodine 12. Malignant Hyperthermia and Free Radicals Part IV: Diagnosis of Malignant Hyperthermia 13. The North American Protocol for the Caffeine Halothane Contracture Test in the Diagnosis of Malignant Hyperthermia 14. Measurement of Calcium-Induced Calcium Release Activity in the Sarcoplasmic Reticulum Membrane with Special Reference to Diagnosis of Malignant Hyperthermia 15. Measurement of Calcium Accumulation by Sarcoplasmic Reticulum in Whole Homogenate — a Potential Diagnostic Test for Malignant Hyperthermia Susceptibility 16. Noninvasive Screening for Malignant Hyperthermia by Means of the Lymphocyte Test 17. A Noninvasive Diagnosis of Malignant Hyperthermia: Direct Thermometry of Intramuscular Temperature Part V: New Developments in Malignant Hyperthermia Research and Molecular Genetic Diagnosis of Malignant Hyperthermia 18. The Genetic Basis of Malignant Hyperthermia 19. Demonstration of the Mutation Associated with Porcine Stress Syndrome 20. Molecular Genetic Diagnosis of Human Malignant Hyperthermia

Biography

S. Tsuyoshi Ohnishi (Author) ,  Tomoko Ohnishi (University of Pennsylvania) (Author)