Cellular Membrane: A Key to Disease Processes focuses on cellular membranes as a key to unlocking important new information about the pathological processes of strokes, heart attacks, diabetes, cancer, and other major diseases. The clinical relevance of basic research is particularly emphasized. Topics include calcium ions and calcium channel blockers, membrane ion channels and diabetes, membrane perturbation by asbestos fibers and disease, membrane receptors and signal transduction in tumor cells, anti-HIV compounds with membrane oriented specificity, and neuroleptic malignant syndrome.
Cellular Membrane: A Key to Disease Processes is filled with illustrations, schemes, exciting ideas, and provocative hypotheses that are bound to lead to the development of new pharmacological techniques. It will prove to be an excellent reference guide for cell biologists and pathologists.
Overview: Importance of Biological Membranes in Disease Processes (S.T.Ohnishi). Membrane Transport and membrane Receptors: Calcium Ions and Calcium Channel Blockers (J. Ferrante and D.J. Triggle). Features of the ATP-Sensitive Potassium Channel in Vascular Smooth Muscles (K. Kitamura, S. Kajioka, M. Nakashima, M. Kamouchi, Z. Xiong, M. Kuriyama, and H. Kuriyama). Membrane Ion Channels and Diabetes (Y. Oosawa). Microcirculatory Disturbances and Autonomic Nervous Receptors in Acute Gastric Mucosal Lesion (M. Tsuchiya, M. Nakamura, and M. Oda). Membrane Perturbation by Asbestos Fibers and Disease (L.A. Goodglick and A.B. Kane). Membrane Receptors and Signal Transduction in Tumor Cells (M. Ruggiero). Membrane Injury, Ions, and Free Radicals: Effects of Hypoxia on Neuronal Membranes (G.G. Somjen). The Pathogenetic Mechanism Underlying Cerebral Vasospasm (T. Asano, T. Matsui, T. Watanabe, T. Koide, and Y. Takuwa). Study of Free Radical Generation in Isolated Cells and Whole Tissues Using Electron Paramagnetic Resosnance Spectroscopy (P. Kuppusamy and J.L. Zweier). Gastric Mucosal Injury (Toshikazu Yoshikawa and Motoharu Kondo). Renal Ischemia (C. Green, L. Cotterill, and J. Gower). Membrane Alterations and Membrane-Acting Drugs: Cancer and Cell Membranes (T. Galeotti and L. Masotti). Anti HIV Compounds with Membrane Oriented Specificity-Early Results (C.A. Stein and R. Pal). Prostaglandin Derivatives as Chemotherapeutic Agents in Cancer, AIDS, and Malaria (S. Tsuyoshi Ohnishi). Dystrophin Defect in Duchenne and Becker Muscular Dystrophy (K.Arahata and H. Sugita). Neuroleptic Malignant Syndrome (C.A. Pearlman). Index.