The Physiology of Immunity
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Summary
The study of neuroendocrine-immune interactions has become a highly visible and fast-growing segment of mainstream immunology. This book provides an overview of the immune system and in-depth coverage of the many different areas that make up neuroendocrine-immune research. The main emphasis is on the physiology of the processes involved, stressing an integrated approach to immunology.
The text is organized in seven sections, beginning with an introduction to the immune system. Section II outlines how the central nervous system (CNS) communicates with central and peripheral lymphoid organs. Section III provides information on factors from the immune system that act as messengers to the CNS. The metabolic regulation of growth and development is discussed in Section IV. Section V examines the interactions occurring between the reproductive and immune systems. The effects of other physiologic stressors on immunity are reviewed in Section VI. Section VII considers cyclic and periodic influences on the immune system. Finally, there is a consideration of a new unifying theory for immunology.
Students, researchers, clinicians, and veterinary scientists can discover new areas of interest in specific diseases and immune interactions in this novel presentation.
Table of Contents
An Overview of the Immune System Histophysiology of the Lymphoid System-The Thymus and T Cells, P. Nieuwenhuis
The Origin, Development, and Differentiation of B Lymphocytes, D. Hummell and A.R.Lawton
Macrophages, Polymorphonuclear Neutrophils, and Natural Killer Cells: The Rapid Response Sector of the Immune System, R.R. Dietert, T.E. Miller, and K. Golemboski
Neuropeptides and the Immune System, C. Heijnen and A. Kavelaars
Mediators of CNS Activity-Neuroendocrine-Immune (NEI) Interactions
Peripheral and Central Neural Mechanisms for Immune Regulation through the Innervation of Immune Effector Sites, J.E.G. Downing and M.D. Kendall
The Role of Calcitonin Gene-Related Peptide (CGRP) and Other Sensory Neuropeptides in Modulating Inflammation and Immunity, J.P. McGillis and H.F. Figuiredo
CNS Biogenic Amines and the Immune System, A.J. Dunn and N.R.S. Hall
Interactive Effects of Cytokines in the Brain: Sleep, Fever, and Anorexia, L. Kapás and J.M. Krueger
Neuroendocrine Functions of Lymphoid System
The Neuroendocrine Activity of the Thymus, M.D. Kendall and J.A. Marsh
Relationship between the Neuro-Endocrine System and the Bursa of Fabricius, S.H.M. Jeurissen
Metabolic Regulation of Growth and Development-NEI Interactions
Effects of Growth Hormone, Insulin-Like Growth Factor-I (IGF-I) and Somatostatin on Immune Function and Development, W. Murphy
Interactions between the Thyroid and the Immune System, J.A. Marsh and G.F. Erf
Reproduction-NEI Interactions
Estrogen-Mediated Interactions between the Immune and Female Reproductive Systems, J.C. Chapman, R. Despande, and S.D. Michael
The Role of Androgens-Androgen Receptor on Immune System Activity, T.-M. Lin, R. Lustig, and C. Chang
The Placenta, J.S. Hunt and M.J. Soares
Unique Neuroendocrine-Immune Interactions during Pregnancy, B. Marchetti, F. Gallo, Z. Farinella, and M.C. Morale
Stress and Neuroendocrine-Immune Interactions
The Hypothalamic-Pituitary-Adrenocortical Immune Axis, J. Buckingham, H.C. Christian, G.E. Gillies, J.G. Philip, and A.D. Taylor
Impact of Behavior on Immunity: Phenomena and Mechanisms, D. Lysle, L. Perez, and K.A. Maslonek
Physiologic Cyclicity and Immunity
Circadian Rhythms and Immunity: T-Helper-2 Cells as Targets of the Circadian Melatonin Signal, J.G.M. Maestroni
Periodic Cycles and Immunity, A.G. Zapata
Aging and Immunity, M.M.B. Kay
Conclusion
Is a "Unitarian" Approach to Immunology Possible?, A.N. Shmakov and M.D. Kendall
Index
