This book considers clinical problems associated with new modalities of cancer treatment involving recombinant cytokines. The first half of the book is devoted to various types of associations of cytokines with tumor cells, while the second half addresses the therapeutic potential of multidisciplinary devices in biological treatment with recombinant cytokine. Some of these indicate the future direction of cancer treatment.
Overview: Cancer Control by Cytokines (Y. Hashimoto). Roles of Cytokines in Human Neoplastic Cell Growth: Role of Interleukin 6 in Pathogenesis of B Lymphocyte-Proliferative Diseases (K. Yoshizaki, N. Nishimoto, K. Kondo, H. Tagoh, and T. Kuritani). Involvement of IL-6 in Development of Myeloma (M. Kawano and O. Tanabe). Roles of IL-6 and NF-IL6 in AIDS Kaposi Sarcoma (H. Isshiki, S. Akira, and T. Kishimoto). Alterations in Cell Growth Regulatory System by Transforming Growth Factor-ß in Human Hepatocellular Carcinoma (S. Kawata, S. Tamura, N. Ito, K. Takaishi, and Y. Matsuzawa). Growth Inhibitory Activity of Interleukin-3 on Human Nonhematopoietic Tumor Cell Lines (K. Miyagawa, F. Taketazu, C. Misawa, T. Kuwaki, K. Miyazono, and F. Takaku). Autocrine Growth of Leukemia Cells Producing Cytokines (N. Nara). Antitumor Effector Mechanism and Its Potentiation by Cytokines: In Vitro and In Vivo Antitumor Activities of Monocytes Potentiated by Macrophage Colony-Stimulating Factor (M-CSF) (K. Motoyoshi, M. Douzono, T. Sakurai, and N. Yanai). Induction of Interleukin 2-Activated Killer Effector Activity and Its Regulatory Mechanism (S. Sone, A. Nii, and T. Ogura). Bispecific Antibody as a Potentiator of Tumor Cell Killing by IL-2-Activated Lymphocytes (H. Yagita, M. Ikeda, T. Nitta, K. Sato, K. Okumura, and S. Ishii). Role of Tumor-Associated Antigens in Induction of Specific Killing by Cytotoxic T Lymphocytes in Human Autologous Cancers (N. Sato, Y. Wada, H. Ikeda, S. Takahashi, N. Tsuboi, A. Kishi, K. Hirata, and K. Kikuchi). Human Tumor-Infiltrating Lymphocytes (K. Itoh, C.M. Balch, A.C. von Eschenbach, T. Morita, K. Hayakawa, and D. Seito). Interleukin-2 Receptor-Targeted Therapy of ATL (T. Uchiyama, A. Kondo, T. Kiyokawa, K. Yamaguchi, J.R. Murphy, and K. Takatsuki). Antitumor Properties and Possible Application for Gene Therapy with IL-2 Activated Killer Cells (Y. Kohgo, Y. Itoh, N. Watanabe, X. Liu, Y. Koshida, H. Neda, T. Himeno, M. Takahashi, and Y. Niitsu). Clinical and Biological Aspects of Interferon-a in the Treatment of Chronic Myelogenous Leukemia (K. Tani, H. Ogura, T. Inoue, A. Tojo, K. Ozawa, and S. Asano). Future Prospect (F. Takaku). Subject Index. Author Index.