Animal Lectins

Animal Lectins: A Functional View

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Features

  • Discusses lectin-mediated cell adhesion and cell surface lattice formation
  • Examines lectins that participate in glycoprotein folding, sorting and secretion, targeting, degradation, and clearance
  • Studies lectins that are involved in cell-cell interactions, signaling, and transport
  • Contains an attached CD with more than 70 color illustrations
  • Addresses lectins that are involved in the recognition and effector functions in innate and adaptive immunity
  • Presents recently discovered lectins and lectin families
  • Includes a 16-page color insert

 

Summary

Introduces Groundbreaking Approaches for Assessing Lectin Function

Lectins and their ligands are under quite a heavy microscope due to their potential applications to pharmacology, immunology, cancer therapy, and agriculture. With growing interest in the glycobiology field, the body of research related to lectin roles has grown at an explosive rate, particularly in the past 20 years. Animal Lectins: A Functional View presents the most up-to-date analysis of these carbohydrate-binding, and potentially lifesaving, proteins in one comprehensive volume.

This standard-setting resource presents new insights into the biological roles of most animal lectins, including their function in infection prevention through innate immunity. It also discusses such lectin behaviors as:

  • Glycoprotein folding
  • Sorting and targeting
  • Cell adhesion
  • Embryogenesis
  • Cell-cell interactions and signaling

Describes the Structural Basis of Protein-Carbohydrate Interactions

Under the editorial guidance of two leading protein chemistry experts and with contributions from well-recognized field authorities, this book logically and systematically discusses both intracellular and extracellular lectin functions. It is an essential springboard for future field research and a clear and concise knowledge base that glycobiology, biochemistry, and immunology researchers cannot afford to be without.

Table of Contents

INTRODUCTION

Introduction to Animal Lectins, G.R. Vasta and H. Ahmed

MODERN APPROACHES FOR ASSESSING LECTIN FUNCTION

Structural Aspects of Lectin–Ligand Interactions, M.A. Bianchet, H. Ahmed, G.R. Vasta, and L.M. Amzel

Thermodynamic Approaches to the Study of Affinity of Clustered Carbohydrate Epitopes in Galectin–Glycoconjugate Interactions, T.K. Dam and C.F. Brewer

Deciphering Lectin Ligands through Glycan Arrays, D.F. Smith and R.D. Cummings

Chromatography and Related Approaches for Qualitative and Quantitative Analyses of Lectin Specificity, J. Hirabayashi

Analysis of Whole-Genome and Other Data Resources to Characterize the Molecular, Structural, and Evolutionary Diversity of C-Lectins and Discover New Genes, A.N. Zelensky and J.E. Gready

Animal Models for Assessing the Biological Roles of Lectins, H. Ahmed, G.A. Rabinovich, S.S. Jackson, M. Salatino, K. Saito, G. Bianco, S. Tasumi, S.-J. Du, and G.R. Vasta

GLYCOPROTEIN FOLDING, SORTING AND SECRETION, TARGETING, DEGRADATION, AND CLEARANCE

Calreticulin and Calnexin as Chaperones in Glycoprotein Folding, J.J. Caramelo and A.J. Parodi

Role of L-Type Lectins in Glycoprotein Sorting and Trafficking, B. Nyfeler, M.W. Wendeler, and H.-P. Hauri

P-Type Lectins and Lysosomal Enzyme Targeting, N.M. Dahms, L.J. Olson, and J.-J.P. Kim

M-Type Lectins as Novel Components of Secretory Pathways, N. Hosokawa and K. Nagata

Functional Aspects of the Hyaluronan and Chondroitin Sulfate Receptors, E.N. Harris and P.H. Weigel

CELL ADHESION AND CELL SURFACE LATTICE FORMATION

Galectin-3 and Cancer, Y. Wang, V. Balan, and A. Raz

Myelin-Associated Glycoprotein (Siglec-4): A Nervous System Lectin That Regulates Axon–Myelin Stability and Axon Regeneration, R.L. Schnaar and N.R. Mehta

Hyaluronan-Binding Proteoglycans, E.N. Harris and P.H. Weigel

Roles of Coral Lectins in Morphological Change of Zooxanthellae, H. Kamiya, M. Jimbo, K. Koike, and R. Sakai

CELL–CELL INTERACTIONS, SIGNALING, AND TRANSPORT

Siglecs: Roles in Cell–Cell Interactions and Signaling, C.O. and P.R. Crocker

Signaling through the Fungal b-Glucan Receptor Dectin-1, A.M. Kerrigan, K.M. Dennehy, and G.D. Brown

CD22: A Regulator of B Cell Survival and Signal Transduction, S.H. Smith and T.F. Tedder

Galectins and Integrins in Pre-B Cell Development, M. Espeli, L. Gauthier, S. Mancini, F. Mourcin, B. Rossi, and C. Schiff

Golgi N-Glycan Processing and Galectin Functions, K.S. Lau, I.R. Nabi, M. Demetriou, and J.W. Dennis

RECOGNITION AND EFFECTOR FUNCTIONS IN INNATE IMMUNITY

Mannan-Binding Lectin Polymorphisms and Infectious Diseases, M. Møller-Kristensen, S. Thiel, and J.C. Jensenius

Immunoregulatory Roles of Lung Surfactant Proteins A and D, N. Palaniyar, G.L. Sorensen, and U. Holmskov

C-Type Lectin Receptors on Dendritic Cells, Y. van Kooyk

Structural and Functional Roles of C-type Lectin Receptors on Natural Killer Cells, N. Dimasi

Activation of Lepidopteran Insect Innate Immune Responses by C-type Immulectins, X.-Q. Yu and M.R. Kanost

Galectins as Novel Regulators of Immune Cell Homeostasis and Inflammation, G. A. Rabinovich, M.A. Toscano, J.M. Ilarregui, and L.G. Baum

Interactions of Galectins with Leukocytes, S.R. Stowell and R.D. Cummings

Regulation of Immune Responses by Galectin-3, D. K. Hsu and F.-T. Liu

X-Lectins: A New Family with Homology to the Xenopus laevis Oocyte Lectin XL-35, J.K. Lee and M. Pierce

F-Type Lectins: A New Family of Recognition Factors, G.R. Vasta, E.W. Odom, M.A. Bianchet, L.M. Amzel, K. Saito, and H. Ahmed

Biology of FREPs: Diversified Lectins with Fibrinogen-Related Domains from Freshwater Snail Biomphalaria glabrata, B.A. Stout, C.M. Adema, S.-M. Zhang, and E.S. Loker

Lectins in Sand Fly–Leishmania Interactions, S. Kamhawi and J.G. Valenzuela

Ficolins: The Structural Basis for Recognition Plasticity, M. Matsushita, Y. Endo, and T. Fujita

Hemolytic Lectin in Marine Invertebrates, T. Hatakeyama

Structure–Function Relationship in Mammalian Chitinase-Like Lectins, S. Morroll, S. Turner, and F.H. Falcone

Index

 
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