Molecular and Cellular MR Imaging

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ISBN 9780849372520
Cat# 2526



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  • Provides the first comprehensive introduction to an overview of cellular and molecular MR imaging
  • Draws from a distinguished panel of authors, all of whom are leaders in their field
  • Summarizes the multiple disciplines that are involved in the advancement of magnetic resonance imaging including chemistry, physics, medicine, biology, imaging and image analysis
  • Examines the diverse applications for modern MR imaging in research and medicine
  • Showcases the future directions and imminent advancements in the field
  • Summary

    The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and cellular biology, chemistry, physics, image analysis, and drug discovery to develop and translate promising approaches into reliable scientific applications and viable clinical diagnostic tools.

    Bringing together a select panel of internationally recognized authors, Molecular and Cellular MR Imaging provides a state-of-the-science overview of the multidisciplinary nature of the field and illustrates the application of these various sciences to investigate specific biological processes in animals and humans. Using a systematic organization to present diverse information, the text begins with an introductory chapter that defines cellular and molecular imaging and explains why magnetic resonance imaging (MRI) is the most versatile approach for noninvasive, in vivo studies. The first section examines the physicochemical principles of various contrast agents including paramagnetic, superparamagnetic, CEST, and PARACEST agents, as well as smart and sensing agents. The second section summarizes the wide variety of applications for molecular imaging of genes and of disease states. Contributions cover cancer, apoptosis, cardiovascular and neurodegenerative disease, and the use of pharmacological MRI. The third section is devoted to cellular imaging under a variety of applications, and the final section discusses the translational aspects and future directions of cellular and molecular MR imaging.

    Molecular and Cellular MR Imaging highlights the diversity of skills required to translate advancements in various fields of research into practical applications that promise to revolutionize in vivo imaging as a diagnostic tool.

    Table of Contents

    What Is Molecular and Cellular Imaging?, M.M. Modo and J.W.M. Bulte

    Contrast Agents for Molecular and Cellular Imaging
    Physicochemical Principles of MR Contrast Agents, P. Caravan
    Paramagnetic Contrast Agents, S. Aime, Z. Baranyai, E. Gianolio, and E. Terreno
    Superparamagnetic Contrast Agents, C. Corot, M. Port, I. Guilbert, P. Robert, I. Raynal,
    C. Robic, J.S. Raynaud, P. Prigent, A. Dencausse, and J.M. Idée
    Physical Mechanism and Applications of CEST Contrast Agents, M.T. McMahon, J. Zhou, A.A. Gilad, and P.C.M. van Zijl
    PARACEST Contrast Agents, A.D. Sherry and M. Woods
    Genetic Approaches for Modulating MRI Contrast, E. T. Ahrens, W. F. Goins, and C.S. Robison

    Molecular MR Imaging
    Molecular and Functional MR Imaging of Cancer, M. A. Jacobs, K. Glunde, B. Gimi, A. P. Pathak,
    E. Ackerstaff, D.Artemov, and Z. M. Bhujwalla
    Molecular Imaging of Atherosclerosis with Magnetic Resonance, K. C. Briley-Saebo, W.J. Mulder, F. Hyafil, V. Mani, V. Amirbekian, J. Gilberto, S. Aguinaldo, J. F. Rudd, S. H. Aguiar, and Z.A. Fayad
    Molecular Imaging of Apoptosis, M. I. Kettunen and K. M. Brindle
    Molecular Imaging of Reporter Genes, K. Ziv, D. Granot, V. Plaks, B. Cohen, and M. Neeman
    Pharmacological MRI as a Molecular Imaging Technique, Y. I. Chen and B. G. Jenkins

    Cellular MR Imaging
    Cellular MR Imaging of the Liver Using Contrast Agents, N. C. Balci and S. Mehmet Erturk
    Cellular Imaging of Macrophage Activity in Infection and Inflammation, M. Rausch, M. Rudin, P. Allegrini, and N. Beckmann
    Cellular Imaging of Macrophage Activity in Stroke, R. Weber and M. Hoehn
    Magnetic Resonance Imaging in Developmental Biology, C. Papan, J. M. Tyszka, and R. E. Jacobs
    Methods for Labeling Non-phagocytic Cells with MR Contrast Agents, J.A. Frank, S. A. Anderson, and A. S. Arbab
    Cellular Imaging of Cell Transplants, M.M.J.J. Modo and J.W.M. Bulte
    Cellular and Molecular Imaging of the Diabetic Pancreas, Z. Medarova and A. Moore
    Functional Cellular Imaging with Manganese, V. Van Meir and A. Van der Linden

    Future Perspectives for Molecular and Cellular Imaging
    Translating Promising Experimental Approaches to Clinical Trials, A. D. Nunn
    An Outlook on Molecular and Cellular MR Imaging, M. Modo and J. W.M. Bulte

    Editorial Reviews

    "The excellent chapter about methods for labeling nonphagocytic cells is noteworthy . . . will be valuable for researchers in the field of molecular imaging to recess their knowledge or use as a reference book."

    – Fabian Kiessling, Department of Medical Physics in Radiology, Juniorgroup Molecular Imaging, German Cancer Research Center, in International Journal of Radiation Oncology Biology & Physics, 2007 Vol. 69, No. 4