Handbook of Psychiatric Genetics

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ISBN 9780849344862
Cat# 4486
 

Features

  • Offers approaches to studying and understanding the central nervous system and human behavior
  • Addresses the controversial nature of genetic studies and includes a discussion of ethical issues in scientific conduct
  • Highlights the one gene, one disorder (OGOD) and quantitative trait loci (QTL) approaches
  • Includes more than 100 figures and tables
  • Summary

    Psychiatric genetics is an exciting new discipline that explores how our minds and behavior are influenced by our genes. Increased interest in this area of medical genetics has been sparked by advances in molecular genetic techniques, the genome project, the neurosciences, the role of genes in somatic diseases, and the linking of specific genes with complex mental disorders. This Handbook is the definitive resource on this complex, and sometimes controversial, new field.

    Table of Contents

    Section I: Genetic Mechanisms in Psychiatry: Analytic Approaches
    Association Vs. Linkage Analysis in Mental Disorders, E.M. Wijsman
    Genetic Association Studies in Psychiatry: Recent History, J. Gelertner
    The Value of Narrow Psychiatric Phenotypes "Super" Normal Controls, S. Hill and K. Neiswander
    Section II: DNA Analysis
    Isolation of Coding Sequences from the Human Genome: Implication for Neurological Functions and Diseases, P. Jagadeeswaran, M.W. Odom, and Y.C. Liu
    Identification of Microsatellite Repeat Markers and Transcribed Sequences in Cloned Genomic DNA, S.R. Pantanjali , R.P. Kandpal, H. Xu, and S.M. Weissman
    Section III: Molecular Biology of Receptors and Associated Proteins
    Molecular Biology of Opiod Receptors and Associated Proteins, L.N. Wei and H.H. Loh
    Phenotypic Analysis of Receptor Genes: Role of Muscarinic Receptor Genes in Neuropsychiatric Disease, M. Braun and Y. Kimura
    Studies on Dopamine Receptors and Role in Drug Addiction, G.Y. Ng, S.R. George, and B.F. O'Dowd
    Serotonergic Receptors: Role in Psychiatry, J.M. Scalzitti and J.G. Hensler
    Brain Adernergic Receptors, D.A. Morilak
    Emerging Bacterial Models for GABA Receptors and Transporters, S.C. King
    Section IV: Psychiatric Genetics
    Identification of Phenotypes for Molecular Genetic Studies of Common Childhood Psychopathology, J. Hudziak
    Molecular Genetics of Alzheimer's Disease, G.D. Schellenberg
    Polygenic Inheritance in Psychiatric Disorders, D.E. Comings
    Molecular Linkage Studies of Manic-Depressive Illness, W. Berrettini
    The Genetics of Personality, T.J. Bouchard, Jr.
    Family-Based Association of Attention Deficit/Hyperactivity Disorder and the Dopamine Transporter, E.H. Cook, Jr., M.A. Stein, and B.L. Leventhal
    Reward Deficiency Syndrome: Neurobiological and Genetic Aspects, K. Blum, J.G. Cull, E.R. Braverman, T.H.J. Chen, and D.E. Comings
    Section V: Substance Use Disorders
    Polymorphisms of the D2 Dopamine Receptor Gene in Alcoholism, Cocaine and Nicotine Dependence, and Obesity, E.P. Noble
    Polymorphisms of the D2 Receptor Gene in Polysubstance Abusers, A.M. Persico and G. Uhl
    Association Vs. Linkage Analysis in Compulsive Disorder, A. Parisian, R.D. Todd, and C.R. Cloninger
    Association of the A1 and B1 Alleles of the Dopamine D2 Receptor Gene in Severe Japanese Alcoholics, T. Arinami, M. Otokawa, T. Komiyama, H. Mitsushio, H. Mori, H. Mifune, and M. Toru
    Behavior Genetic Investigations of Cigarette Smoking and Related Issues in Twins, G.E. Swann and D. Carmeli
    The Dopamine D2 Receptor Gene Locus in Reward Deficiency Analysis: Meta-Analyses, K. Blum, P.J. Sheridan, T.J.H. Chen, R.C. Wood, E.R. Braverman, J.G. Cull, and D.E. Comings
    Section VI: From Animal Research to Society: Genetic Impact on Behavior
    Mapping Quantitative Trait Loci for Behavioral Traits in the Mouse, J.K. Belknap, C. Dubay, J.C. Crabbe, and K.J. Buck
    Drug Discrimination: A Tool to Unravel the Genetic Determinants of Alcohol Preference and Aversion, G. Colombo, R. Agabio, C. Lobina, R. Reali, F. Fadda, and G.L. Gessa
    Ethical Issues: Genetic Screening, Gene Therapy, and Scientific Conduct, L.S. Parker and E. Gettig
    Index

    Editorial Reviews

    "…the authors of the Handbook of Psychiatric Genetics are to be congratulated."
    --Wilfrid Noel Raby, M.D., Ph.D., The Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 10, No. 2

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