Implantation Biology: The Host Response and Biomedical Devices

Published:
March 24, 1994 by CRC Press - 432 Pages
Editor(s):
Ralph S. Greco, Stanford University School of Medicine, California, USA

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ISBN 9780849344329
Cat# 4432
 

Features

  • Characterizes the host implant interface at both the basic science and clinical level
  • Provides an in-depth definition of the interactions of cells with a variety of biomaterials used in clinical practice
  • Enumerates the clinical applications of biomaterials regarding surfaces utilized in clinical disciplines
  • Gives an historical perspective of the evolution of clinically utilized biomaterials, as well as a look at future directions in biomaterial research
  • Examines the current status of biomaterials in relation to the host response at a cellular molecular level, discusses the clinical relevance of biomaterials in medical practice, and introduces developing technologies that may become the basis of future clinically relevant implants and devices

    • Summary

    This new book is the first of its kind to characterize the host implant interface at both the basic science and clinical level. The book defines the interactions of various cell types with a variety of biomaterials by discussing the basic science of these interactions. This study is important because in today's world of bionics, implantable devices represent a major component of medical practice. They are associated with significant cost and substantial benefit to many patients and morbid complications for many others. Advances in biotechnology promise to lead to the development of artificial prosthetic organs in the near future, compounding this already complex milieu. Implantation Biology enumerates the clinical applications of biomaterials from the surface viewpoint in multiple disciplines. It provides the reader with an historical perspective of the evolution of these clinically utilized biomaterials, as well as an important look at future directions in biomaterials and artificial organs research. Chapters are written by internationally respected experts in their fields and offer both a comprehensive review of biomaterial sciences and a unique specialty-by-specialty analysis of clinical applications.

    Table of Contents

    Biomaterials: An Historical Perspective (D.W. Friedman, P.J. Orland, and R.S. Greco). Physical and Chemical Aspects of Biomaterials Used in Humans (R.E. Marchant and I-w. Wang). The Effect of Biomaterials on the Host (E.T. Choi and A.D. Callow). Blood and Biomaterials (R.A. Sheppeck and F.W. LoGerfo). Inflammation and Biomaterials (R. Shankar and H.P. Greisler). Endothelial Cells and Biomaterials (J.D. Trachtenberg and U.S. Ryan). The Extracellular Matrix and Biomaterials (J.M. Anderson). Bacteria and Biomaterials (A.G. Gristina, G. Giridhar, and Q.N. Myrvik). Integrins, Adhesion Molecules, and Biomaterials (M.S. Margiotta, L.D. Benton, and R.S. Greco). Biomaterials Used in Cardiac Surgery (O.H. Frazier, K.A. Kadipasaoglu, S.M. Parnis, and B. Radovancevic). Biomaterials in Peripheral Vascular Surgery (D.K. Wilkerson and M.A. Zatina). Biomaterials Used in Plastic Surgery (J.C. Yuen, B. Klitzman, and D. Serafin). Biomaterials Used in Orthopaedic Surgery (M.G. Dunn and S.H. Maxian). Biomaterials Used in Neurosurgery (M.G. Nosko and L.D. Frenkel). Biomaterials Used for Catheters (S.Z. Trooskin and A.W. Mikulaschek). Biomaterials Used in Urology (J.G. Barone and K.B. Cummings). Biomaterials Used in Hernia Repair, Abdominal Wall Replacement, and the Intestinal Sling Procedure (D.F. Devereux and S.M. O'Connell). Genetic Manipulation of Endothelium and Vascular Smooth Muscle (T.A. Whitehill, L.A. Messina, and J.C. Stanley). Utilization of Prosthesis for Drug Delivery (R.A. Harvey). Artificial Organs (J.P.A. Lodge and A.P. Monaco). Tissue Engineering (F. Berthiaume, M. Toner, R.G. Tompkins, and M.L. Yarmush). Genetic Engineering and Therapeutics (J.R. Morgan and M.L. Yarmush). Conclusions (R.S. Greco).

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