Inhalation Toxicology, Second Edition

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  • Focuses on the methods, measurements, and mechanisms of inhalation toxicology
  • Includes coverage of the inhalation of biological agents
  • Discusses the importance of developing chemical exposure numbers for emergency response planning purposes
  • Highlights the use of new techniques such as toxicokinetic models, genomics, and proteomics
  • Features coverage of in vivo studies and animal models, therapeutics, and chemicals
  • Examines the data, methods, models, and guidelines used in health risk assessment to determine inhalation endpoints
  • Summary

    Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances and examine methods and measurements for improving our understanding of the basic mechanisms of effects.

    The book delineates key issues in the field such as regulatory aspects of exposure and testing, testing equipment and methods, biomarkers, pathology, allergies and immunology, irritation of the respiratory tract, and risk assessment. It covers the inhalation of bioaerosols and toxins, ranging from anthrax to household molds as well as genomics, proteomics, and low-level exposure toxicants such as tobacco smoke and chemical warfare agents. Highlights include coverage of the Acute Exposure Guidelines and Emergence Response Guidelines and recent changes in the European and American guidelines for testing procedures.

    The book focuses on key issues associated with airborne substances and provides critical reviews of the latest advances. Presenting sophisticated concepts in a readable, accessible format, the book distills the latest information into practical knowledge.

    Table of Contents

    Inhalation Risk Assessment at the Environmental Protection Agency, J.E. Whalan, G.L. Foureman, and J.J. Vandenburg
    The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances, G.M. Rush
    Emergency Response Planning Guidelines (ERPGs), F. Cavender
    Directed Flow Aerosol Inhalation Exposure Systems: Application to Pathogens and Highly Toxic Agents, R.J. Jaeger, S.G. Shami, and L. Tsenova
    Whole-Body, Low-Level Sarin Vapor Exposure in Rats: Estimating the Probability of Miosis as a Function of Exposure Concentration and Duration, R.J. Mioduszewski, R.G. Crosier, W.T. Muse, Jr., D.R. Sommerville, and S.A. Thomson
    Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example, D.W. Porter and A.F. Hubbs
    The Use of Large Animals in Inhalation Toxicology, R.F.R. Brown, B.J.A. Jugg, and J. Jenner
    Toxic Load Modeling, D.R. Sommerville, K.H. Park, M.O. Kierzewski, M.D. Dunkel, M.I. Hutton, and N.A. Pinto
    Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program, E.K. Weisburger and V.W. Hudson
    Combustion Toxicology, B. Levin

    Toxicogenomics of Low-Level Nerve Agent Vapor Exposure, J.W. Sekowski
    Respiratory Sensitization, M. Blackwell
    Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure, B. Ballantyne
    Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles, F. Huaux
    Hormesis: Implications for Risk Assessment, E. Calabrese
    Nasal Toxicology, J.B. Morris
    Effects of Inhaled Toxicants on the Nose and Nasal Function, P. Dalton and R. Opiekun
    Toxicokinetics: Deposition, Absorption, Distribution, and Excretion, M.A. Inchiosa, Jr.
    Pharmacokinetics of Hydrocarbons and Mixtures, K. Krishnon
    Inhalation Toxicology of an Irritant Gas: Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure, A.M. Sciuto
    Inhalation Toxicology of Riot Control Agents, H. Salem, B. Ballantyne, and S.A. Katz
    Chemical Warfare Agents and Nuclear Weapons, N.M. Elsayed and H. Salem
    Inhalation Toxicology of Metals (Chromium), S.A. Katz and H. Salem
    Safety Assessment of Therapeutic Agents Administered by the Inhalation Route, S. Gad
    Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract, G.L. Finch

    Inhalation Toxicology of Alcohol/Gasoline Fuels: Current Status, R. Poon
    Asbestos, D.M. Bernstein
    The Inhalation Toxicity of Benzene, R. Synder and M. von Raaij
    Carbon Monoxide, J.J. McGrath
    Experimental, Clinical, Occupational Toxicology and Forensic Aspects of Hydrogen Cyanide and Particular Reference to Vapor Exposure, B. Ballantyne and H. Salem
    The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans, S.R. Lane, P.J. Nichols, and R.D.E. Sewell
    Fluorocarbon Alternatives: Methodologies for Special Studies and Results, D.E. Dodd and W.J. Brock
    Animal Models for Three Major Cigarette-Smoke-Induced Diseases, R.R. Schleef, P.M. Vanscheeuwijik, W.K. Schlage, J.F. Borelleca, C.R.E. Coggins, and H-J. Haussmann
    The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health, S-J.T. Todd and S.T. Omaye

    Health Aspects of Bioaerosols, K.P. O'Connell and H. Salem
    Emerging Biothreats: Natural and Deliberate, J.M. Mann and N.D. Connell
    Toxicology Associated with Respiratory Exposures to Fungi (Molds), M.D.W. Ward, Y.J. Chung, and M.J.K. Selgrade
    Inhalation of Botulinum Toxins, M. Adler
    Inhalation of Ricin: Aerosol Procedures, Animal Toxicology, and Therapy, R.W. Wannemacher, Jr. and H.B. Anderson
    Inhalation Toxicology & Phamacology of Biologicals and Toxins: Prophylaxis and Therapy, B. Paddle

    Editorial Reviews

    " … an invaluable source of information for the professional toxicologist … helps the advanced student of toxicology to understand the specific aspects of inhalation toxicology. For the professor of toxicology, it is an abundant source of material that can be used in graduate and postgraduate teaching."
    —Hermann M. Bolt, Toxicological and Environmental Chemistry

    "The stated aim of the book is to provide the practicing professional as well as the aspiring student with a pragmatic textbook and in this it succeeds well. … this wide-ranging book provides a comprehensive overview of inhalation toxicology and will be of interest to most people working in this field."
    —Tom Allen, The British Toxicology Society Newsletter