Neurobehavioral Genetics: Methods and Applications

Published:
June 28, 1999 by CRC Press - 416 Pages
Editor(s):
Byron C. Jones, Pennsylvania State University, University Park, USA; Pierre Mormede, INRA, Head-Laboratoire de Neurogenetique et Stress, Bordeaux, France

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ISBN 9780849333644
Cat# 3364
 

Features

  • o Covers contemporary quantitative and molecular genetic applications in the study of the brain and behavior
  • Serves as an excellent resource for investigators who want to incorporate genetic methods into neurobehavioral and psychiatric research
  • Integrates a broad spectrum of methods in a single source, unlike any other book currently in print
  • Presents different models, from invertebrates to genetically defined mammals to humans

    • Summary

    Neurobehavioral Genetics: Methods and Applications covers classic and contemporary approaches to the study of the brain and behavior, including basic and clinical research. This book is designed as a reference for investigators wishing to incorporate genetic methods into neurobehavioral research. A broad spectrum of methods are integrated, unlike any other publication currently in print.
    Neurobehavioral Genetics: Methods and Applications presents different models, from invertebrates to genetically defined mammals.
    Introductory chapters demonstrate the scope and power of genetic methods that can be applied to neurobehavioral research from statistical methods and linkage analysis to contemporary molecular genetic approaches to search for candidate genes.
    The second half of the book covers the applications of quantitative and molecular genetics in basic and clinical research. Topics covered include animal behavior and neurobiology and human clinical problems including neurodegenerative diseases and psychiatric disorders.

    Table of Contents


    A Retrospect on Neurobehavioral Genetics
    PART 1: BASIC QUANTITATIVE AND STATISTICAL METHODS
    An Introduction to Quantitative Genetics
    Planning Genetic Experiments: Power and Sample Size
    Classical Linkage Analysis
    PART 2: MOVING FROM MATHEMATICS TO GENES
    Neurogenetics: Mendelian Genetics - Single-Gene Effects and Some of Their Complicating Factors
    Quantitative Trait Loci (QTL) Mapping
    From QTL Detection to Gene Identification-M. P. Moisan
    Knockouts: Constitutive, Inducible, or Tissue Specific. The Example of 5-HT Receptors-R. Grailhe and R. Hen
    PART 3: ANIMAL MODELS
    Behavioral Phenotyping of Transgenic and Knockout Mice-J. N. Crawley
    Animal Models in Neurobehavioral Genetics: Methods for Estimating Genetic Correlation - John C. Crabbe
    PART 4: HUMAN METHODS
    Human Family Studies-L. M. Karkowski
    The Twin Method-M. Carlier and E. Spitz
    PART 5: GENE-ENVIRONMENT INTERACTIONS AND MATERNAL EFFECTS
    Detecting and Measuring Gene-Environment Interaction in Human Temperament (Aggressivity) and Personality Deviation (Conduct Disorder, Antisocial Personality)-K. Riggins-Caspers and
    R. J. Cadoret
    Maternal Effects in Behavior Genetic Analysis-
    M. Carlier, P. Roubertoux, and D. Wahlsten
    PART 6: METHODS AND APPLICATIONS IN NEUROGENETICS
    Cerebellar Functions: A Behavioral Neurogenetic Perspective-L. Rondi-Reig, J. Caston, N. Delhaye-Bouchaud, and J. Mariani
    Natural Genetic Variation of Hippoccampal Structures and Behavior-H. P. Lipp and D. P. Wolfer
    Human Neurogenetics: Neurodegenerative Diseases-A. D. Dürr
    PART 7: PSYCHIATRIC GENETICS
    Schizophrenia: Study of a Genetically Complex Phenotype-M. F. Pogue-Geile and I. I. Gottesman
    Genetics of Autism and Its Place in an Integrated Clinicobiological Approach-S. Tordjman
    Genetic Basis of Mental Retardation-L. Colleaux
    PART 8: GENETICS OF AGGRESSION AND EMOTIONALITY
    Aggression: Concepts and Methods Relevant to Genetic Analyses n Mice and Humans-S. Maxson
    Genetics and Emotional Behaviors: Experimental Studies-P. Mormède and A. Ramos



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