Apoptosis in Neurobiology

Series:
Frontiers in Neuroscience
Published:
December 24, 1998 by CRC Press - 296 Pages
Editor(s):
Yusuf A. Hannun, Medical University of South Carolina, Charleston, USA; Rose-Mary Boustany, Duke University Medical Center, Durham, North Carolina, USA

Purchasing Options

Hardback
$179.95
Add to cart
ISBN 9780849333521
Cat# 3352
 

Features

  • Provides ready access to the various methods currently used in the study and evaluation of apoptosis
  • Discusses the significance, utility, and interpretation of methods and approaches
  • Provides background information for each approach to help scientists determine the relevancy of apoptosis to their research

    • Summary

    The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death-has created an urgent need for reliable documentation of the different approaches to and methods of studying the various aspects of the field. Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated neuroscientist intellectual and practical access to the study of apoptosis, with special consideration to the nervous system. The first section concentrates on conceptual approaches to the study of apoptosis in neurobiology and its significance to the nervous system. The second section provides a user-friendly approach to methods and techniques in the study of apoptosis as applied to neurobiology.

    Table of Contents

    Preface
    Diseases and Concepts
    Introduction: Occurrence, Mechanisms, and Role of Apoptosis in Neurobiology and in Neurologic Disorders, R.-M. Boustany and Y.A. Hannun
    Cell Death in the Developing Nervous System, V. Narayanan
    Neurodegenerative Disorders, D. Schmechel
    Neurooncology and Cancer Therapy, N.F. Schor
    Human Immunodeficiency Virus Type I, H.A. Gelbard
    The Role of Proteases in Neuronal Apoptosis, S. Kaufmann
    Molecular Mechanisms in the Activation of Apoptotic and Anti-Apoptotic Pathways by Ceramide, R. Dobrowsky
    Methods
    Assessment of Cell Viability and Histochemical Methods in Apoptosis, K. Puranam and R.-M. Boustany
    Assessment of Ultrastructural Changes Associated with Apoptosis, D. Schmechel
    Flow Cytometry in the Study of Apoptosis, M. Smyth
    Methods Used to Study Protease Activation During Apoptosis, S. Kaufmann
    Qualitative and Quantitative Methods for the Measurement of Ceramide, R. Dobrowsky
    In Vivo Neuronal Targeting of Genes, A. Amalfitano

    Editorial Reviews

    ... provides a nice introduction to the field of neuronal apoptosis and to methods for identifying apoptotic cells. ... the editor and authors are to be commended for providing a coherent, although detailed overview, indicated by an average of over 170 references per chapter.
    -Joseph A. Bobich, Chemistry, Texas Christian University, Fort Worth, Texas, USA

    Related Titles