Methods for NEURAL ENSEMBLE RECORDINGS

Published:
December 23, 1998 by CRC Press - 272 Pages
Editor(s):
Miguel A. L. Nicolelis, Duke University Medical Center, Durham, North Carolina, USA

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ISBN 9780849333514
Cat# 3351
 

Features

  • Provides methods for handling simultaneous neuronal ensemble recordings
  • Enables professionals to complete recordings that will assist in understanding key issues such as neural networks, parallel processing, and neuronal basis of behavior, learning, and memory
  • Offers clear, concise descriptions, tips, and examples from world experts

    • Summary

    Neuroscientists have long recognized the importance of understanding the underlying principles of information processing by large populations of neurons. Methods for Neural Ensemble Recordings explores methods for using electrophysiological techniques for monitoring the concurrent activity of ensembles of single neurons. Since current methods allow one to simultaneously record the extracellular activity of up to 100-150 neurons for days or even weeks, neural ensemble recordings have been used to address long-standing issues in development, learning, memory, sensorimotor integration, sensory information processing, and neuronal plasticity.

    EXAMINES THE MANY POSSIBLE APPLICATIONS FOR THIS REVOLUTIONARY METHOD

    Each chapter offers a step-by-step description for the implementation of a particular technique or experimental paradigm employing simultaneous multiple electrode recordings. The techniques described can be used in applications that impact a large group of life scientists, including:

  • drug screening (pharmacology) in both in vitro and in vivo preparations
  • developmental studies and studies of neuronal plasticity
  • chronic monitoring of neuronal function in behavioral studies
  • physiological monitoring of neuronal activity in cell cultures and brain slices
  • physiological monitoring of neuronal activity in neurons trafected with genetic vectors
  • chronic monitoring of physiological changes in populations of neurons during learning of new sensorimotor and cognitive tasks

    • Table of Contents

    Electrodes for Many Single Neural Recordings, E. Schmidt
    Multi-Channel Electrode Design: Considerations for Different Applications, K.A. Moxon
    Trends in Multichannel Neural Ensemble Recording Instrumentation, K. Sameshima and L.A. Baccala
    Automatic Discrimination of Single Units, B.C. Wheeler
    Acute in vivo Multielectrode Recording from the Cerebellum, J.P. Welsh and Cornelius Schwarz
    Methods for Chronic Neural Ensemble Recordings in Singing Birds, A.S. Dave, A.C. Yu, J.J. Gilpin, and D. Margoliash
    Methods for Simultaneous Multisite Neural Ensemble Recordings in Behaving Primates, M.A.L. Nicolelis, C.R. Stambaugh, A. Brisben, and M. Laubach
    Correlations Based Analysis Methods for Neural Ensemble Data, G.L. Gerstein
    Directed Coherence: A Tool for Exploring Functional Interactions among Brain Structures, L.A. Baccala and K. Sameshima
    Using Multivariate Statistical Methods to Analyze Multi-Single Neuron Recording Data, J.K. Chapin
    Pitfalls and Problems in the Analysis of Neural Ensemble Recordings during Behavioral Tasks, R.E. Hampson and S.A. Deadwyler

    Editorial Reviews

    "This volume leads readers through microelectrode design, choice and availability; hardware and software for simultaneous sampling; and neural ensemble data analysis."
    -Joel L. Davis, Cognitive & Neural Systems Division, Office of Naval Research, Arlington, Virginia, USA

    "Nicolelis' long chapter is the most informative. It provides a clear soup-to-nuts recipe for recording from neuronal ensembles."
    -Joel L. Davis, Cognitive & Neural Systems Division, Office of Naval Research, Arlington, Virginia, USA

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