Forensic DNA Evidence Interpretation

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ISBN 9780849330179
Cat# 3017



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ISBN 9781420037920
Cat# E3017



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  • Includes 60 tables that simplify advanced principles for the caseworker
  • Provides a review of pertinent biology
  • Presents contributions from experts in statistical analysis and DNA
  • Reviews noteworthy cases such as the identity of the Romanovs and the O.J. Simpson trial
  • Summary

    Forensic DNA Evidence Interpretation is the most comprehensive resource for DNA casework available today. Written by leaders in the fields of biology and statistics, the book emphasizes the interpretation of test results and provides the necessary formulae in an easily accessible manner.

    The book begins by reviewing all pertinent biology, and then provides information on every aspect of DNA analysis, including modern interpretation methods and issues, and contemporary population genetic models available for estimating DNA frequencies or likelihood ratios. Following a chapter on procedures for validating databases, the text presents overviews and performance assessments of both modern sampling uncertainty methods and current paternity testing techniques. Later chapters discuss the latest methods for mixture analysis, LCN (ultra trace) analysis, and non-autosomal (mito, X, and Y) DNA analysis. The text concludes with procedures for disaster victim identification and information on DNA intelligence databases.

    Supported by numerous tables and over 800 references, this authoritative book provides a link among the biological, forensic, and interpretative domains of the DNA profiling field. It is a valuable resource that allows forensic scientists and technicians, molecular biologists, and attorneys to use forensic DNA evidence to its greatest potential.

    Table of Contents

    Biological Basis for DNA Evidence, Peter Gill and John Buckleton
    Historical and Background Biology
    Understanding PCR Profiles
    A Framework for Interpreting Evidence, John Buckleton
    The Frequentist Approach
    The Logical Approach
    The Full Bayesian Approach
    A Possible Solution
    A Comparison of the Different Approaches
    Population Genetic Models, John Buckleton
    Product Rule
    Simulation Testing
    Discussion of the Product Rule and the Subpopulation Model
    A Complex Case Example - DNA Evidence and Orethral James Simpson
    Relatedness, John Buckleton and Christopher Triggs
    Conditional Probabilities
    Joint Probabilities
    The Unifying Formula
    The Effect of Linkage
    Validating Databases, John Buckleton
    Which Is the Relevant Population?
    Population Databases
    Validating the Population Genetic Model
    Estimating Q
    Descriptive Statistics for Databases
    Sampling Effects, John Buckleton and James Curran
    Bounds and a Level
    Methods for Assessing Sampling Uncertainty
    Minimum Allele Probabilities
    Discussion of the Appropriateness of Sampling Uncertainty Estimates
    Mixtures, Tim Clayton and John Buckleton
    Frequentist Approaches
    Bayesian Approaches
    Statistical Evaluation of Mixtures
    Low Copy Number, John Buckleton and Peter Gill
    Changes in LCN Profile Morphology
    The Interpretation of LCN Profiles
    Non-autosomal Forensic Markers, Simon Walsh, SallyAnn Harbison, and John Buckleton
    Forensic Mitochondrial DNA Typing
    Forensic Y Chromosome Analysis
    Forensic X Chromosome Analysis
    A Famous Case Example - The Romanovs
    Parentage Testing, John Buckleton, Tim Clayton, and Chris Triggs
    Evaluation Of Evidence
    Paternity Trios: Mother, Child and Alleged Father
    Non-autosomal DNA
    Use of the Sub-Population Model of Balding and Nichols to Evaluate the Paternity Index
    Relatedness in Paternity Cases
    Multiple Children
    Inconsistencies in the Mendelian Pattern
    Paternity Trios: Mother, Child and Alleged Father Considering the Possibility of Silent (Null) Alleles
    Disaster Victim Identification, Identification of Missing Persons, and Immigration Cases, John Buckleton, Chris Triggs, and Tim Clayton
    Mitochondrial or Nuclear DNA?
    Human Remains - Obtaining a Profile from Bodily Remains
    Extraction of DNA from Bone, Tooth, Hair and Nail
    Complicating Factors
    DNA Intelligence Databases, Simon Walsh and John Buckleton
    A Brief History
    Functional Aspects
    Aspects of Forensic Significance
    Social and ethical considerations
    Interpretation Issues Associated with DNA Databases