Animal Models of Cognitive Impairment

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ISBN 9780849328343
Cat# 2834



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ISBN 9781420004335
Cat# E2834



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  • Integrates molecular and neurochemical approaches to behavioral application in translational animal models and clinical applications
  • Features cutting-edge research on genetic, lesion, pharmacological toxicant, and aging models
  • Includes contributions from distinguished active researchers in the field of cognitive therapy research
  • Summary

    The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans.

    Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications.

    The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD.

    Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

    Table of Contents

    Introduction; Edward D. Levin and Jerry I Buccafusco
    Pharmacologic Models
    Muscarinic Receptor Antagonists in Rats; Alvin V Terry, Jr.
    Nicotinic Receptor Antagonists in Rats; Cindy S.  Roegge and Edward D. Levin
    Involvement of the NMDA System in Learning and Memory; Amir H. Rezvani
    Animal Models and the Cognitive Effects of Ethanol; Merle G. Paule

    Toxicologic Models
    Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure; Deborah C. Rice
    Developmental Behavioral Toxicity of Methylmercury: Consequences, Conditioning, and Cortex; M. Christopher Newland, Wendy D. Donlin, Elliott M. Paletz, and Kelly M. Banna
    Executive Function following Developmental Exposure to Polychlorinated Biphenyls (PCBs): What Animal Models Have Told Us; Helen J.K. Sable and Susan L. Schantz
    Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey; J.S. Schneider

    Mouse Genetic Models
    Cognitive Jmpairment in Transgenic Mouse Models of Amyloid Deposition; Dave Morgan
    Cholinergic Receptor Knockout Mice; Lu Zhang
    Assessments of Cognitive Deficits in Mutant Mice; Ramona Marie Rodriguiz and William C. Weisel

    Model Applications and Future Developments
    Cognitive Pharmacology in Aging Macaques; Jerry J. Buccaflisco
    Cognitive Impairment following Traumatic Brain Injury; Mark D. Whiting, Anna I. Baranova, and Robert J. Jdamm
    Cognitive Impairment Models Using Complementary Species; Daniel T. Cerutti and Edward D. Levin
    Cognition Models and Drug Discovery; Michael W Decker

    Editorial Reviews

    “This book has summarized the widely used animal models of cognitive impairment. The majority of the animal models are related to cognitive pharmacology. … The animals models of cognitive impairment described in this book are diverse and involve common cognitive diseases such as AD and schizophrenia. A general coverage of the broad aspects of cognitive impairment is realized. Besides the discussion of different animals for different cognitive syndromes, molecular, chemical and other approaches have been incorporated. All illustrated models were introduced by a short historical introduction and were critically discussed in the context of relevant literature. Each chapter ended with outlining the current state of the field and a short conclusion/summary. …”
    — Rinske Vlamings, Department of Neuroscience, Maastricht University, The Netherlands, Yasin Temel,  Department of Neurosurgery, University Hospital Maastricht, The Netherlands, in the Journal of Chemical Neuroanatomy, Vol. 33, No. 4, February 2007