Food-Drug Synergy and Safety
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Summary
Scientists, health professionals, and consumers are increasingly interested in the relationships between food components and food-drug combinations as they strive to find more effective ways to prevent or treat chronic disease. As one of the first unified and in-depth sources in this emerging topic, Food-Drug Synergy and Safety explores the vast potential benefits of food and food-drug synergy.
The book addresses the interaction of two or more components within a single food, between several foods, or between foods and drugs consumed together, in which the potential health benefit is greater than the effect of the single component, food, or drug. Each chapter follows a consistent framework and addresses the health benefits, mechanisms of action, and safety aspects pertaining to the food and food-drug synergies. Sections discuss food and food-drug synergies in the context of specific disease groups, such as cardiovascular disease, cancer, osteoporosis, inflammatory diseases, hypertension, and obesity, for easy reference in a clinical setting. A separate section focuses entirely on performance enhancers, including caffeine, creatine, and ephedrine/ephedra, and their potential to influence human health in addition to ergogenic applications.
The final section provides scientists with a framework for designing experiments that elucidate the heath benefits and safety aspects of food and food-drug synergies. Food-Drug Synergy and Safety lays the essential foundation in this new direction of research as it gains momentum in the fields of food, nutrition, medicine, and pharmaceutical sciences.
Table of Contents
Section I: Introduction
Understanding Food and Food-Drug Synergy; Wendy E. Ward and Lilian U. Thompson
Section II: Cardiovascular Disease
Lipid Sources and Plant Sterols: Effect of Food and Food-Drug Synergy on Cardiovascular Disease Risk; Krista A. Varady and Peter J.H. Jones
Antioxidant Phytochemicals and Potential Synergistic Activities at Reducing Risk of Cardiovascular Disease; David D. Kitts
Synergy of Portfolio Diet Components and Drugs in Coronary Heart Disease; David J.A. Jenkins, Augustine Marchie, Julia M. Wong, Russell de Souza, Azadeh Emam, and Cyril W.C. Kendall
The Role of Complementary Vitamins, Folate, Vitamin B6, and Vitamin B12, in Cardiovascular Disease; Louise Mennen, Pilar Galan, and Angelika de Bree
Food Synergy in Dietary Patterns and Risk for Chronic Diseases; Rob M. van Dam
Section III: Cancer
Soy-Food and Soy-Drug Interactions in Prevention and Treatment of Cancer; Jin-Rong Zhou
Flaxseed, Lignans, n-3 Fatty Acids, and Drug Synergy in the Prevention and Treatment of Cancer; Lilian U. Thompson
Whole-Grain Component Synergy and Cancer; Joanne Slavin
Synergy and Safety of Antioxidants with Cancer Drugs; Kedar N. Prasad
Probiotics: Synergy with Drugs and Carcinogens in Diet; Seppo Salminen, Hani El-Nezami, Eeva Salminen, and Hannu
Mykkänen
Section IV: Osteoporosis
Synergy of Soy, Flaxseed, Calcium, and Hormone Replacement Therapy in Osteoporosis; Wendy E. Ward
Synergy of Protein, Fats, and Calcium; Potential Synergies with Drugs for Osteoporosis; Marlena C. Kruger and Raewyn C. Poulsen
Section V: Inflammatory Disease, Hypertension, and Obesity
Molecular Targets for Antiinflammation and Dietary Component-Drug Synergy Akira Murakami and Hajime Ohigashi
Food and Food-Drug Synergies: Role in Hypertension and Renal Disease Protection; Manuel T. Velasquez
Milk Proteins in Food-Food and Food-Drug Synergy on Feeding Behavior, Energy Balance, and Body Weight Regulation; Alfred Aziz and G. Harvey Anderson
Section VI: Ergogenics
Caffeine, Creatine, and Food-Drug Synergy: Ergogenics and Applications to Human Health; Terry E. Graham and Lesley L. Moisey
Section VII: Experimental Designs
Designing Experiments for Food-Drug Synergy: Health Aspects; Lyn M. Steffen
Designing Experiments for Food-Drug Synergy: Safety Aspects; V.J. Feron, J.P. Groten, R.J.J. Hermus, D. Jonker, I. Meijerman, G.J. Mulder, F. Salmon, and E.D. Schoen
Index
